Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent von Merchant, Mark, Ma, Xiaolei, Maun, Henry R, Zheng, Zhong, Peng, Jing, Romero, Mally, Huang, Arthur, Yang, Nai-ying, Nishimura, Merry, Greve, Joan, Santell, Lydia, Zhang, Yu-Wen, Su, Yanli, Kaufman, Dafna W, Billeci, Karen L, Mai, Elaine, Moffat, Barbara, Lim, Amy, Duenas, Eileen T, Phillips, Heidi S, Xiang, Hong, Young, Judy C, Vande Woude, George F, Dennis, Mark S, Reilly, Dorothea E, Schwall, Ralph H, Starovasnik, Melissa A, Lazarus, Robert A, Yansura, Daniel G

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Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge von Maun, Henry R., Vij, Rajesh, Walters, Benjamin T., Morando, Ashley, Jackman, Janet K., Wu, Ping, Estevez, Alberto, Chen, Xiaocheng, Franke, Yvonne, Lipari, Michael T., Dennis, Mark S., Kirchhofer, Daniel, Ciferri, Claudio, Loyet, Kelly M., Yi, Tangsheng, Eigenbrot, Charles, Lazarus, Robert A., Koerber, James T.

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An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides von Landgraf, Kyle E, Steffek, Micah, Quan, Clifford, Tom, Jeffrey, Yu, Christine, Santell, Lydia, Maun, Henry R, Eigenbrot, Charles, Lazarus, Robert A

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Efficient production of antibodies against a mammalian integral membrane protein by phage display von Hötzel, Isidro, Chiang, Vicki, Diao, Jingyu, Pantua, Homer, Maun, Henry R., Kapadia, Sharookh B.

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Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele von Kauder, Steven E, Santell, Lydia, Mai, Elaine, Wright, Lilyan Y, Luis, Elizabeth, N'Diaye, Elsa N, Lutman, Jeff, Ratti, Navneet, Sa, Susan M, Maun, Henry R, Stefanich, Eric, Gonzalez, Lino C, Graham, Robert R, Diehl, Lauri, Faubion, Jr, William A, Keir, Mary E, Young, Judy, Chaudhuri, Amitabha, Lazarus, Robert A, Egen, Jackson G

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Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism von Merchant, Mark, Vajdos, Felix F., Ultsch, Mark, Maun, Henry R., Wendt, Ulrich, Cannon, Jennifer, Desmarais, William, Lazarus, Robert A., de Vos, Abraham M., de Sauvage, Frederic J.

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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma von Maun, Henry R., Jackman, Janet K., Choy, David F., Loyet, Kelly M., Staton, Tracy L., Jia, Guiquan, Dressen, Amy, Hackney, Jason A., Bremer, Meire, Walters, Benjamin T., Vij, Rajesh, Chen, Xiaocheng, Trivedi, Neil N., Morando, Ashley, Lipari, Michael T., Franke, Yvonne, Wu, Xiumin, Zhang, Juan, Liu, John, Wu, Ping, Chang, Diana, Orozco, Luz D., Christensen, Erin, Wong, Manda, Corpuz, Racquel, Hang, Julie Q., Lutman, Jeff, Sukumaran, Siddharth, Wu, Yan, Ubhayakar, Savita, Liang, Xiaorong, Schwartz, Lawrence B., Babina, Magda, Woodruff, Prescott G., Fahy, John V., Ahuja, Rahul, Caughey, George H., Kusi, Aija, Dennis, Mark S., Eigenbrot, Charles, Kirchhofer, Daniel, Austin, Cary D., Wu, Lawren C., Koerber, James T., Lee, Wyne P., Yaspan, Brian L., Alatsis, Kathila R., Arron, Joseph R., Lazarus, Robert A., Yi, Tangsheng

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Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling von Landgraf, Kyle E., Santell, Lydia, Billeci, Karen L., Quan, Clifford, Young, Judy C., Maun, Henry R., Kirchhofer, Daniel, Lazarus, Robert A.

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Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist von Kirchhofer, Daniel, Lipari, Michael T, Santell, Lydia, Billeci, Karen L, Maun, Henry R, Sandoval, Wendy N, Moran, Paul, Ridgway, John, Eigenbrot, Charles, Lazarus, Robert A

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Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site von Maun, Henry R., Wen, Xiaohui, Lingel, Andreas, de Sauvage, Frederic J., Lazarus, Robert A., Scales, Suzie J., Hymowitz, Sarah G.

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Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma von Jackman, Janet K., Stockwell, Amy, Choy, David F., Xie, Markus M., Lu, Peipei, Jia, Guiquan, Li, Hong, Abbas, Alexander R., Bronson, Paola G., Lin, Wei-Yu, Chiu, Cecilia P.C., Maun, Henry R., Roose-Girma, Merone, Tam, Lucinda, Zhang, Juan, Modrusan, Zora, Graham, Robert R., Behrens, Timothy W., White, Steven R., Naureckas, Ted, Ober, Carole, Ferreira, Manuel, Sedlacek, Radislav, Wu, Jiansheng, Lee, Wyne P., Lazarus, Robert A., Koerber, James T., Arron, Joseph R., Yaspan, Brian L., Yi, Tangsheng

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Dual functionality of β-tryptase protomers as both proteases and cofactors in the active tetramer von Maun, Henry R., Liu, Peter S., Franke, Yvonne, Eigenbrot, Charles, Forrest, William F., Schwartz, Lawrence B., Lazarus, Robert A.

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Engineering Exosite Peptides for Complete Inhibition of Factor VIIa Using a Protease Switch with Substrate Phage von Maun, Henry R., Eigenbrot, Charles, Lazarus, Robert A.

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The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling von de Sauvage, Frederic J, Hymowitz, Sarah G, Lazarus, Robert A, Bosanac, Ivan, Maun, Henry R, Scales, Suzie J, Wen, Xiaohui, Lingel, Andreas, Bazan, J Fernando

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Development of a specific immunoassay to selectively measure active tryptase in airway samples von Sperinde, Gizette, Bremer, Meire, Maun, Henry R, Baruch, Amos, Lazarus, Robert A, Koerber, James T, Vij, Rajesh, Yi, Tangsheng, Fischer, Saloumeh K, Staton, Tracy

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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma von Maun, Henry R., Jackman, Janet K., Choy, David F., Loyet, Kelly M., Staton, Tracy L., Jia, Guiquan, Dressen, Amy, Hackney, Jason A., Bremer, Meire, Walters, Benjamin T., Vij, Rajesh, Chen, Xiaocheng, Trivedi, Neil N., Morando, Ashley, Lipari, Michael T., Franke, Yvonne, Wu, Xiumin, Zhang, Juan, Liu, John, Wu, Ping, Chang, Diana, Orozco, Luz D., Christensen, Erin, Wong, Manda, Corpuz, Racquel, Hang, Julie Q., Lutman, Jeff, Sukumaran, Siddharth, Wu, Yan, Ubhayakar, Savita, Liang, Xiaorong, Schwartz, Lawrence B., Babina, Magda, Woodruff, Prescott G., Fahy, John V., Ahuja, Rahul, Caughey, George H., Kusi, Aija, Dennis, Mark S., Eigenbrot, Charles, Kirchhofer, Daniel, Austin, Cary D., Wu, Lawren C., Koerber, James T., Lee, Wyne P., Yaspan, Brian L., Alatsis, Kathila R., Arron, Joseph R., Lazarus, Robert A., Yi, Tangsheng

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Crystal Structure Analysis of Free and Substrate-Bound 6-Hydroxy-l-Nicotine Oxidase from Arthrobacter nicotinovorans von Kachalova, Galina S., Bourenkov, Gleb P., Mengesdorf, Thorsten, Schenk, Susann, Maun, Henry R., Burghammer, Manfred, Riekel, Christian, Decker, Karl, Bartunik, Hans D.

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Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer von Maun, Henry R., Kirchhofer, Daniel, Lazarus, Robert A.

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Structural and Functional Basis of the Serine Protease-like Hepatocyte Growth Factor β-Chain in Met Binding and Signaling von Kirchhofer, Daniel, Yao, Xiaoyi, Peek, Mark, Eigenbrot, Charles, Lipari, Michael T., Billeci, Karen L., Maun, Henry R., Moran, Paul, Santell, Lydia, Wiesmann, Christian, Lazarus, Robert A.

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Disulfide locked variants of factor VIIa with a restricted β‐strand conformation have enhanced enzymatic activity von Maun, Henry R., Eigenbrot, Charles, Raab, Helga, Arnott, David, Phu, Lilian, Bullens, Sherron, Lazarus, Robert A.

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