Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency... von Edwards, Philip D, Albert, Jeffrey S, Sylvester, Mark, Aharony, David, Andisik, Donald, Callaghan, Owen, Campbell, James B, Carr, Robin A, Chessari, Gianni, Congreve, Miles, Frederickson, Martyn, Folmer, Rutger H. A, Geschwindner, Stefan, Koether, Gerard, Kolmodin, Karin, Krumrine, Jennifer, Mauger, Russell C, Murray, Christopher W, Olsson, Lise-Lotte, Patel, Sahil, Spear, Nate, Tian, Gaochao

Volltext

Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu 5) von Varnes, Jeffrey G., Marcus, Andrew P., Mauger, Russell C., Throner, Scott R., Hoesch, Valerie, King, Megan M., Wang, Xia, Sygowski, Linda A., Spear, Nathan, Gadient, Reto, Brown, Dean G., Campbell, James B.

Volltext

Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases von EDWARDS, Philip D, MAUGER, Russell C, COTTRELL, Kevin M, MORRIS, Frank X, PINE, Kara K, SYLVESTER, Mark A, SCOTT, Clay W, FURLONG, Stephen T

Volltext

Synthesis and physical characterization of a P1 arginine combinatorial library, and its application to the determination of the substrate specificity of serine peptidases von FURLONG, Stephen T, MAUGER, Russell C, STRIMPLER, Anne M, LIU, Yi-Ping, MORRIS, Frank X, EDWARDS, Philip D

Volltext

Discovery and Biological Activity of Orally Active Peptidyl Trifluoromethyl Ketone Inhibitors of Human Neutrophil Elastase von Edwards, Philip D, Andisik, Donald W, Bryant, Craig A, Ewing, Barbara, Gomes, Bruce, Lewis, Joseph J, Rakiewicz, Donna, Steelman, Gary, Strimpler, Ann, Trainor, Diane A, Tuthill, Paul A, Mauger, Russell C, Veale, Chris A, Wildonger, Richard A, Williams, Joseph C, Wolanin, Donald J, Zottola, Mark

Volltext

C3 activation is inhibited by analogs of compstatin but not by serine protease inhibitors or peptidyl α-ketoheterocycles von Furlong, Stephen T, Dutta, Anand S, Coath, Matthew M, Gormley, James J, Hubbs, Stephen J, Lloyd, Darleen, Mauger, Russell C, Strimpler, Anne M, Sylvester, Mark A, Scott, Clay W, Edwards, Philip D

Volltext

Mechanism for slow-binding inhibition of human leukocyte elastase by valine-derived benzoxazinones von Stein, Ross L., Strimpler, Ann M., Viscarello, Barbara R., Wildonger, Richard A., Mauger, Russell C., Trainor, D. Amy

Volltext

Synthesis and physical characterization of a P 1 arginine combinatorial library, and its application to the determination of the substrate specificity of serine peptidases von Furlong, Stephen T., Mauger, Russell C., Strimpler, Anne M., Liu, Yi-Ping, Morris, Frank X., Edwards, Philip D.

Volltext

Synthesis and enzymatic evaluation of a P 1 arginine aminocoumarin substrate library for trypsin-like serine proteases von Edwards, Philip D., Mauger, Russell C., Cottrell, Kevin M., Morris, Frank X., Pine, Kara K., Sylvester, Mark A., Scott, Clay W., Furlong, Stephen T.

Volltext

The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. part 1 von Veale, Chris A, Alford, Vernon C, Aharony, David, Banville, Debra L, Bialecki, Russell A, Brown, Frederick J, Damewood, James R, Dantzman, Cathy L, Edwards, Philip D, Jacobs, Robert T, Mauger, Russell C, Murphy, Megan M, Palmer, Willam E, Pine, Kara K, Rumsey, William L, Garcia-Davenport, Laura E, Shaw, Andrew, Steelman, Gary B, Surian, Jean M, Vacek, Edward P

Volltext

4-Alkylpiperidines related to SR-48968: Potent antagonists of the neurokinin-2 (NK 2) receptor von Jacobs, Robert T., Shenvi, Ashok B., Mauger, Russell C., Ulatowski, Terrance G., Aharony, David, Buckner, Carl K.

Volltext

Substituted 2,4-diaminoquinazolines and 2,4-diamino-8-alkylpurines as antagonists of the neurokinin-2 (NK 2) receptor von Jacobs, Robert T., Mauger, Russell C., Ulatowski, Terrance G., Aharony, David, Buckner, Carl K.

Volltext

Positive Allosteric Modulator of SERCA Pump NDC-1173 Exerts Beneficial Effects in Mouse Model of Alzheimer's Disease von Dahl, Russell, Moore, Amanda C, Knight, Caitlynn, Mauger, Colleen, Zhang, Hua, Schiltz, Gary E, Koss, Wendy A, Bezprozvanny, Ilya

Volltext

Effects of copper on CHO cells: Cellular requirements and product quality considerations von Yuk, Inn H., Russell, Stephen, Tang, Yun, Hsu, Wei-Ting, Mauger, Jacob B., Aulakh, Rigzen P. S., Luo, Jun, Gawlitzek, Martin, Joly, John C.

Volltext

Event Excess in the MiniBooNE Search for ν ¯ μ → ν ¯ e Oscillations von Aguilar-Arevalo, A. A., Anderson, C. E., Brice, S. J., Brown, B. C., Bugel, L., Conrad, J. M., Dharmapalan, R., Djurcic, Z., Fleming, B. T., Ford, R., Garcia, F. G., Garvey, G. T., Mirabal, J., Grange, J., Green, J. A., Imlay, R., Johnson, R. A., Karagiorgi, G., Katori, T., Kobilarcik, T., Linden, S. K., Louis, W. C., Mahn, K. B. M., Marsh, W., Mauger, C., Metcalf, W., Mills, G. B., Moore, C. D., Mousseau, J., Nelson, R. H., Nguyen, V., Nienaber, P., Nowak, J. A., Osmanov, B., Pavlovic, Z., Perevalov, D., Polly, C. C., Ray, H., Roe, B. P., Russell, A. D., Schirato, R., Shaevitz, M. H., Sorel, M., Spitz, J., Stancu, I., Stefanski, R. J., Tayloe, R., Tzanov, M., Van de Water, R. G., Wascko, M. O., White, D. H., Wilking, M. J., Zeller, G. P., Zimmerman, E. D.

Volltext

Prognostic Significance of Biomarkers in Pulmonary Arterial Hypertension von Al-Naamani, Nadine, Palevsky, Harold I, Lederer, David J, Horn, Evelyn M, Mathai, Stephen C, Roberts, Kari E, Tracy, Russell P, Hassoun, Paul M, Girgis, Reda E, Shimbo, Daichi, Post, Wendy S, Kawut, Steven M

Volltext

Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design von Oelsner, Elizabeth C, Krishnaswamy, Akshaya, Balte, Pallavi P, Allen, Norrina Bai, Ali, Tauqeer, Anugu, Pramod, Andrews, Howard F, Arora, Komal, Asaro, Alyssa, Barr, R Graham, Bertoni, Alain G, Bon, Jessica, Boyle, Rebekah, Chang, Arunee A, Chen, Grace, Coady, Sean, Cole, Shelley A, Coresh, Josef, Cornell, Elaine, Correa, Adolfo, Couper, David, Cushman, Mary, Demmer, Ryan T, Elkind, Mitchell S V, Folsom, Aaron R, Fretts, Amanda M, Gabriel, Kelley P, Gallo, Linda C, Gutierrez, Jose, Han, Mei Lan K, Henderson, Joel M, Howard, Virginia J, Isasi, Carmen R, Jacobs Jr, David R, Judd, Suzanne E, Mukaz, Debora Kamin, Kanaya, Alka M, Kandula, Namratha R, Kaplan, Robert C, Kinney, Gregory L, Kucharska-Newton, Anna, Lee, Joyce S, Lewis, Cora E, Levine, Deborah A, Levitan, Emily B, Levy, Bruce D, Make, Barry J, Malloy, Kimberly, Manly, Jennifer J, Mendoza-Puccini, Carolina, Meyer, Katie A, Min, Yuan-I Nancy, Moll, Matthew R, Moore, Wendy C, Mauger, David, Ortega, Victor E, Palta, Priya, Parker, Monica M, Phipatanakul, Wanda, Post, Wendy S, Postow, Lisa, Psaty, Bruce M, Regan, Elizabeth A, Ring, Kimberly, Roger, Véronique L, Rotter, Jerome I, Rundek, Tatjana, Sacco, Ralph L, Schembri, Michael, Schwartz, David A, Seshadri, Sudha, Shikany, James M, Sims, Mario, Hinckley Stukovsky, Karen D, Talavera, Gregory A, Tracy, Russell P, Umans, Jason G, Vasan, Ramachandran S, Watson, Karol E, Wenzel, Sally E, Winters, Karen, Woodruff, Prescott G, Xanthakis, Vanessa, Zhang, Ying, Zhang, Yiyi

Volltext

Search for muon neutrino and antineutrino disappearance in MiniBooNE von Aguilar-Arevalo, A A, Anderson, C E, Bazarko, A O, Brice, S J, Brown, B C, Bugel, L, Cao, J, Coney, L, Conrad, J M, Cox, D C, Curioni, A, Djurcic, Z, Finley, D A, Fleming, B T, Ford, R, Garcia, F G, Garvey, G T, Grange, J, Green, C, Green, J A, Hart, T L, Hawker, E, Imlay, R, Johnson, R A, Karagiorgi, G, Kasper, P, Katori, T, Kobilarcik, T, Kourbanis, I, Koutsoliotas, S, Laird, E M, Linden, S K, Link, J M, Liu, Y, Louis, W C, Mahn, K B M, Marsh, W, Mauger, C, McGary, V T, McGregor, G, Metcalf, W, Meyers, P D, Mills, F, Mills, G B, Monroe, J, Moore, C D, Mousseau, J, Nelson, R H, Nienaber, P, Nowak, J A, Osmanov, B, Ouedraogo, S, Patterson, R B, Pavlovic, Z, Perevalov, D, Polly, C C, Prebys, E, Raaf, J L, Ray, H, Roe, B P, Russell, A D, Sandberg, V, Schirato, R, Schmitz, D, Shaevitz, M H, Shoemaker, F C, Smith, D, Soderberg, M, Sorel, M, Spentzouris, P, Spitz, J, Stancu, I, Stefanski, R J, Sung, M, Tanaka, H A, Tayloe, R, Tzanov, M, Van de Water, R G, Wascko, M O, White, D H, Wilking, M J, Yang, H J, Zeller, G P, Zimmerman, E D

Volltext

Discovery of Spirofused Piperazine and Diazepane Amides as Selective Histamine‑3 Antagonists with in Vivo Efficacy in a Mouse Model of Cognition von Brown, Dean G, Bernstein, Peter R, Griffin, Andrew, Wesolowski, Steve, Labrecque, Denis, Tremblay, Maxime C, Sylvester, Mark, Mauger, Russell, Edwards, Phillip D, Throner, Scott R, Folmer, James J, Cacciola, Joseph, Scott, Clay, Lazor, Lois A, Pourashraf, Mehrnaz, Santhakumar, Vijayaratnam, Potts, William M, Sydserff, Simon, Giguère, Pascall, Lévesque, Carine, Dasser, Mohammed, Groblewski, Thierry

Volltext

Test of Lorentz and CPT violation with short baseline neutrino oscillation excesses von Aguilar-Arevalo, A. A., Anderson, C. E., Bazarko, A. O., Brice, S. J., Brown, B. C., Bugel, L., Cao, J., Coney, L., Conrad, J. M., Cox, D. C., Curioni, A., Dharmapalan, R., Djurcic, Z., Finley, D. A., Fleming, B. T., Ford, R., Garcia, F. G., Garvey, G. T., Grange, J., Green, C., Green, J. A., Hart, T. L., Hawker, E., Huelsnitz, W., Imlay, R., Johnson, R. A., Karagiorgi, G., Kasper, P., Katori, T., Kobilarcik, T., Kourbanis, I., Koutsoliotas, S., Laird, E. M., Linden, S. K., Link, J. M., Liu, Y., Louis, W. C., Mahn, K. B. M., Marsh, W., Mauger, C., McGary, V. T., McGregor, G., Metcalf, W., Meyers, P. D., Mills, F., Mills, G. B., Monroe, J., Moore, C. D., Mousseau, J., Nelson, R. H., Nienaber, P., Nowak, J. A., Osmanov, B., Ouedraogo, S., Patterson, R. B., Pavlovic, Z., Perevalov, D., Polly, C. C., Prebys, E., Raaf, J. L., Ray, H., Roe, B. P., Russell, A. D., Sandberg, V., Schirato, R., Schmitz, D., Shaevitz, M. H., Shoemaker, F. C., Smith, D., Soderberg, M., Sorel, M., Spentzouris, P., Spitz, J., Stancu, I., Stefanski, R. J., Sung, M., Tanaka, H. A., Tayloe, R., Tzanov, M., Van de Water, R. G., Wascko, M. O., White, D. H., Wilking, M. J., Yang, H. J., Zeller, G. P., Zimmerman, E. D.

Volltext