Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition von LaRochelle, Jonathan R., Fodor, Michelle, Vemulapalli, Vidyasiri, Mohseni, Morvarid, Wang, Ping, Stams, Travis, LaMarche, Matthew J., Chopra, Rajiv, Acker, Michael G., Blacklow, Stephen C.

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Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor von Garcia Fortanet, Jorge, Chen, Christine Hiu-Tung, Chen, Ying-Nan P, Chen, Zhouliang, Deng, Zhan, Firestone, Brant, Fekkes, Peter, Fodor, Michelle, Fortin, Pascal D, Fridrich, Cary, Grunenfelder, Denise, Ho, Samuel, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Keen, Nick, LaBonte, Laura R, Larrow, Jay, Lenoir, Francois, Liu, Gang, Liu, Shumei, Lombardo, Franco, Majumdar, Dyuti, Meyer, Matthew J, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Sellers, William R, Shultz, Michael D, Stams, Travis, Towler, Christopher, Wang, Ping, Williams, Sarah L, Zhang, Ji-Hu, LaMarche, Matthew J

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Think Biologically, Act Chemically von LaMarche, Matthew J

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Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2 von LaRochelle, Jonathan R, Fodor, Michelle, Xu, Xiang, Durzynska, Izabela, Fan, Lixin, Stams, Travis, Chan, Ho Man, LaMarche, Matthew J, Chopra, Rajiv, Wang, Ping, Fortin, Pascal D, Acker, Michael G, Blacklow, Stephen C

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Efficacy of LFF571 in a Hamster Model of Clostridium difficile Infection von TRZASKO, Anna, LEES, Jennifer A, PRAESTGAARD, Jens, LAMARCHE, Matthew J, MCKENNEY, David

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Discovery of LFF571: An Investigational Agent for Clostridium difficile Infection von LaMarche, Matthew J, Leeds, Jennifer A, Amaral, Adam, Brewer, Jason T, Bushell, Simon M, Deng, Gejing, Dewhurst, Janetta M, Ding, Jian, Dzink-Fox, JoAnne, Gamber, Gabriel, Jain, Akash, Lee, Kwangho, Lee, Lac, Lister, Troy, McKenney, David, Mullin, Steve, Osborne, Colin, Palestrant, Deborah, Patane, Michael A, Rann, Elin M, Sachdeva, Meena, Shao, Jian, Tiamfook, Stacey, Trzasko, Anna, Whitehead, Lewis, Yifru, Aregahegn, Yu, Donghui, Yan, Wanlin, Zhu, Qingming

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Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling von Vemulapalli, Vidyasiri, Chylek, Lily A, Erickson, Alison, Pfeiffer, Anamarija, Gabriel, Khal-Hentz, LaRochelle, Jonathan, Subramanian, Kartik, Cao, Ruili, Stegmaier, Kimberley, Mohseni, Morvarid, LaMarche, Matthew J, Acker, Michael G, Sorger, Peter K, Gygi, Steven P, Blacklow, Stephen C

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Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu von Morris, Rowan P, Leeds, Jennifer A, Naegeli, Hans Ulrich, Oberer, Lukas, Memmert, Klaus, Weber, Eric, LaMarche, Matthew J, Parker, Christian N, Burrer, Nathalie, Esterow, Stacey, Hein, Andreas E, Schmitt, Esther K, Krastel, Philipp

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Predictions of Colloidal Molecular Aggregation Using AI/ML Models von Kombo, David C., Stepp, J. David, Lim, Sungtaek, Elshorst, Bettina, Li, Yi, Cato, Laura, Shomali, Maysoun, Fink, David, LaMarche, Matthew J.

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Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling von Liu, Chen, Lu, Hengyu, Wang, Hongyun, Loo, Alice, Zhang, Xiamei, Yang, Guizhi, Kowal, Colleen, Delach, Scott, Wang, Ye, Goldoni, Silvia, Hastings, William D, Wong, Karrie, Gao, Hui, Meyer, Matthew J, Moody, Susan E, LaMarche, Matthew J, Engelman, Jeffrey A, Williams, Juliet A, Hammerman, Peter S, Abrams, Tinya J, Mohseni, Morvarid, Caponigro, Giordano, Hao, Huai-Xiang

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Antibacterial and Solubility Optimization of Thiomuracin A von LaMarche, Matthew J, Leeds, Jennifer A, Brewer, Jason, Dean, Karl, Ding, Jian, Dzink-Fox, Joanne, Gamber, Gabe, Jain, Akash, Kerrigan, Ryan, Krastel, Philipp, Lee, Kwangho, Lombardo, Franco, McKenney, David, Neckermann, Georg, Osborne, Colin, Palestrant, Deborah, Patane, Michael A, Rann, Elin M, Robinson, Zachary, Schmitt, Esther, Stams, Travis, Tiamfook, Stacey, Yu, Donghui, Whitehead, Lewis

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Antibiotic Optimization and Chemical Structure Stabilization of Thiomuracin A von LaMarche, Matthew J, Leeds, Jennifer A, Dzink-Fox, Joanne, Gangl, Eric, Krastel, Philipp, Neckermann, Georg, Palestrant, Deborah, Patane, Michael A, Rann, Elin M, Tiamfook, Stacey, Yu, Donghui

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Application of artificial intelligence and machine learning techniques to the analysis of dynamic protein sequences von Kombo, David C., LaMarche, Matthew J., Konkankit, Chilaluck C., Rackovsky, S.

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Evolution of a Gram-Scale Synthesis of (+)-Discodermolide von Smith, Amos B, Beauchamp, Thomas J, LaMarche, Matthew J, Kaufman, Michael D, Qiu, Yuping, Arimoto, Hirokazu, Jones, David R, Kobayashi, Kaoru

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6‑Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors von Sarver, Patrick, Acker, Michael, Bagdanoff, Jeffrey T, Chen, Zhouliang, Chen, Ying-Nan, Chan, Homan, Firestone, Brant, Fodor, Michelle, Fortanet, Jorge, Hao, Huaixiang, Hentemann, Murphy, Kato, Mitsunori, Koenig, Robert, LaBonte, Laura R, Liu, Gang, Liu, Shumei, Liu, Chen, McNeill, Eric, Mohseni, Morvarid, Sendzik, Martin, Stams, Travis, Spence, Stan, Tamez, Victoriano, Tichkule, Ritesh, Towler, Christopher, Wang, Hongyun, Wang, Ping, Williams, Sarah L, Yu, Bing, LaMarche, Matthew J

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Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors von Bagdanoff, Jeffrey T, Chen, Zhouliang, Acker, Michael, Chen, Ying-Nan, Chan, Homan, Dore, Michael, Firestone, Brant, Fodor, Michelle, Fortanet, Jorge, Hentemann, Murphy, Kato, Mitsunori, Koenig, Robert, LaBonte, Laura R, Liu, Shumei, Mohseni, Movarid, Ntaganda, Rukundo, Sarver, Patrick, Smith, Troy, Sendzik, Martin, Stams, Travis, Spence, Stan, Towler, Christopher, Wang, Hongyun, Wang, Ping, Williams, Sarah L, LaMarche, Matthew J

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Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers von Hao, Huai-Xiang, Wang, Hongyun, Liu, Chen, Kovats, Steven, Velazquez, Roberto, Lu, Hengyu, Pant, Bhavesh, Shirley, Matthew, Meyer, Matthew J, Pu, Minying, Lim, Joanne, Fleming, Michael, Alexander, LeighAnn, Farsidjani, Ali, LaMarche, Matthew J, Moody, Susan, Silver, Serena J, Caponigro, Giordano, Stuart, Darrin D, Abrams, Tinya J, Hammerman, Peter S, Williams, Juliet, Engelman, Jeffrey A, Goldoni, Silvia, Mohseni, Morvarid

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Dual Allosteric Inhibition of SHP2 Phosphatase von Fodor, Michelle, Price, Edmund, Wang, Ping, Lu, Hengyu, Argintaru, Andreea, Chen, Zhouliang, Glick, Meir, Hao, Huai-Xiang, Kato, Mitsunori, Koenig, Robert, LaRochelle, Jonathan R, Liu, Gang, McNeill, Eric, Majumdar, Dyuti, Nishiguchi, Gisele A, Perez, Lawrence B, Paris, Gregory, Quinn, Christopher M, Ramsey, Timothy, Sendzik, Martin, Shultz, Michael David, Williams, Sarah L, Stams, Travis, Blacklow, Stephen C, Acker, Michael G, LaMarche, Matthew J

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4-Aminothiazolyl analogs of GE2270 A: Design, synthesis and evaluation of imidazole analogs von LaMarche, Matthew J., Leeds, Jennifer A., Dzink-Fox, JoAnne, Mullin, Steve, Patane, Michael A., Rann, Elin M., Tiamfook, Stacey

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Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma von Visser, Michael, Papillon, Julien P. N., Luzzio, Michael, LaMarche, Matthew J., Fan, Jianmei, Michael, Walter, Wang, David, Zhang, Alan, Straub, Christopher, Mathieu, Simon, Kato, Mitsunori, Palermo, Mark, Chen, Christine, Ramsey, Timothy, Joud, Carol, Barrett, Rosemary, Vattay, Anthony, Guo, Ribo, Bric, Anka, Chung, Franklin, Liang, Guiqing, Romanowski, Michael J., Lam, Joni, Thohan, Sanjeev, Atassi, Faraj, Wylie, Andrew, Cooke, Vesselina G.

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