Delineating the role of cooperativity in the design of potent PROTACs for BTK von Zorba, Adelajda, Nguyen, Chuong, Xu, Yingrong, Starr, Jeremy, Borzilleri, Kris, Smith, James, Zhu, Hongyao, Farley, Kathleen A., Ding, WeiDong, Schiemer, James, Feng, Xidong, Chang, Jeanne S., Uccello, Daniel P., Young, Jennifer A., Garcia-Irrizary, Carmen N., Czabaniuk, Lara, Schuff, Brandon, Oliver, Robert, Montgomery, Justin, Hayward, Matthew M., Coe, Jotham, Chen, Jinshan, Niosi, Mark, Luthra, Suman, Shah, Jaymin C., El-Kattan, Ayman, Qiu, Xiayang, West, Graham M., Noe, Mark C., Shanmugasundaram, Veerabahu, Gilbert, Adam M., Brown, Matthew F., Calabrese, Matthew F.

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A covalent BTK ternary complex compatible with targeted protein degradation von Schiemer, James, Maxwell, Andrew, Horst, Reto, Liu, Shenping, Uccello, Daniel P., Borzilleri, Kris, Rajamohan, Nisha, Brown, Matthew F., Calabrese, Matthew F.

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Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1‑((2S,5R)‑5-((7H‑Pyrrolo[2,3‑d]pyrimidin-4-yl)­amino)-2-methylpiperidin-1-yl)­prop-2-en-1-one (PF-06651600) Allowing for the I... von Thorarensen, Atli, Dowty, Martin E, Banker, Mary Ellen, Juba, Brian, Jussif, Jason, Lin, Tsung, Vincent, Fabien, Czerwinski, Robert M, Casimiro-Garcia, Agustin, Unwalla, Ray, Trujillo, John I, Liang, Sidney, Balbo, Paul, Che, Ye, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Leung, Louis, Yang, Xin, Soucy, Sarah, Hegen, Martin, Coe, Jotham, Langille, Jonathan, Vajdos, Felix, Chrencik, Jill, Telliez, Jean-Baptiste

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Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors von Flanagan, Mark E, Abramite, Joseph A, Anderson, Dennis P, Aulabaugh, Ann, Dahal, Upendra P, Gilbert, Adam M, Li, Chao, Montgomery, Justin, Oppenheimer, Stacey R, Ryder, Tim, Schuff, Brandon P, Uccello, Daniel P, Walker, Gregory S, Wu, Yan, Brown, Matthew F, Chen, Jinshan M, Hayward, Matthew M, Noe, Mark C, Obach, R. Scott, Philippe, Laurence, Shanmugasundaram, Veerabahu, Shapiro, Michael J, Starr, Jeremy, Stroh, Justin, Che, Ye

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Informing the Classification and Assessment of Positive Emotional Experiences: A Multisample Examination of Hierarchical Positive Emotionality Models von Stanton, Kasey, Brown, Matthew F. D., McDanal, Riley, Carlton, Corinne N., Emery, Noah N.

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Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection von Flanagan, Mark E, Blumenkopf, Todd A, Brissette, William H, Brown, Matthew F, Casavant, Jeffrey M, Shang-Poa, Chang, Doty, Jonathan L, Elliott, Eileen A, Fisher, Michael B, Hines, Michael, Kent, Craig, Kudlacz, Elizabeth M, Lillie, Brett M, Magnuson, Kelly S, McCurdy, Sandra P, Munchhof, Michael J, Perry, Bret D, Sawyer, Perry S, Strelevitz, Timothy J, Subramanyam, Chakrapani, Sun, Jianmin, Whipple, David A, Changelian, Paul S

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Adaptation-Based Resistance to Siderophore-Conjugated Antibacterial Agents by Pseudomonas aeruginosa von Tomaras, Andrew P, Crandon, Jared L, McPherson, Craig J, Banevicius, Mary Anne, Finegan, Steven M, Irvine, Rebecca L, Brown, Matthew F, O'Donnell, John P, Nicolau, David P

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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes von Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.

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The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA von Sun, Jing, Sun, Quanhong, Brown, Matthew F, Dudgeon, Crissy, Chandler, Julie, Xu, Xiang, Shu, Yongqian, Zhang, Lin, Yu, Jian

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LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens von Tomaras, Andrew P, McPherson, Craig J, Kuhn, Michael, Carifa, Arlene, Mullins, Lisa, George, David, Desbonnet, Charlene, Eidem, Tess M, Montgomery, Justin I, Brown, Matthew F, Reilly, Usa, Miller, Alita A, O'Donnell, John P

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Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-... von Fensome, Andrew, Ambler, Catherine M, Arnold, Eric, Banker, Mary Ellen, Brown, Matthew F, Chrencik, Jill, Clark, James D, Dowty, Martin E, Efremov, Ivan V, Flick, Andrew, Gerstenberger, Brian S, Gopalsamy, Ariamala, Hayward, Matthew M, Hegen, Martin, Hollingshead, Brett D, Jussif, Jason, Knafels, John D, Limburg, David C, Lin, David, Lin, Tsung H, Pierce, Betsy S, Saiah, Eddine, Sharma, Raman, Symanowicz, Peter T, Telliez, Jean-Baptiste, Trujillo, John I, Vajdos, Felix F, Vincent, Fabien, Wan, Zhao-Kui, Xing, Li, Yang, Xiaojing, Yang, Xin, Zhang, Liying

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Delivering on the promise of protein degraders von O’Brien Laramy, Matthew N., Luthra, Suman, Brown, Matthew F., Bartlett, Derek W.

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Unbiased Compound Screening Identifies Unexpected Drug Sensitivities and Novel Treatment Options for Gastrointestinal Stromal Tumors von BOICHUK, Sergei, LEE, Derek J, ZEWE, James, TAGUCHI, Takahiro, KUAN, Shin-Fan, SCHÖFFSKI, Patrick, DEBIEC-RYCHTER, Maria, DUENSING, Anette, MEHALEK, Keith R, MAKIELSKI, Kathleen R, WOZNIAK, Agnieszka, SENEVIRATNE, Danushka S, KORZENIEWSKI, Nina, CUEVAS, Rolando, PARRY, Joshua A, BROWN, Matthew F

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Latent profile analysis and principal axis factoring of the DSM-5 dissociative subtype von Frewen, Paul A., Brown, Matthew F. D., Steuwe, Carolin, Lanius, Ruth A.

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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes von Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.

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Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases von Gerstenberger, Brian S, Ambler, Catherine, Arnold, Eric P, Banker, Mary-Ellen, Brown, Matthew F, Clark, James D, Dermenci, Alpay, Dowty, Martin E, Fensome, Andrew, Fish, Susan, Hayward, Matthew M, Hegen, Martin, Hollingshead, Brett D, Knafels, John D, Lin, David W, Lin, Tsung H, Owen, Dafydd R, Saiah, Eddine, Sharma, Raman, Vajdos, Felix F, Xing, Li, Yang, Xiaojing, Yang, Xin, Wright, Stephen W

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Examining the Item-Level Structure of the Triarchic Psychopathy Measure: Sharpening Assessment of Psychopathy Constructs von Stanton, Kasey, Brown, Matthew F. D., Watson, David

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Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition von Telliez, Jean-Baptiste, Dowty, Martin E, Wang, Lu, Jussif, Jason, Lin, Tsung, Li, Li, Moy, Erick, Balbo, Paul, Li, Wei, Zhao, Yajuan, Crouse, Kimberly, Dickinson, Caitlyn, Symanowicz, Peter, Hegen, Martin, Banker, Mary Ellen, Vincent, Fabien, Unwalla, Ray, Liang, Sidney, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Yang, Xin, Bauman, Jonathan, Trujillo, John I, Casimiro-Garcia, Agustin, Vajdos, Felix F, Leung, Louis, Geoghegan, Kieran F, Quazi, Amira, Xuan, Dejun, Jones, Lyn, Hett, Erik, Wright, Katherine, Clark, James D, Thorarensen, Atli

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Unraveling the Ties that Bind: Social Anxiety is Differentially Related to Vulnerable and Grandiose Narcissistic Traits von Villalongo Andino, Mara, Hauenstein, Neil, Stanton, Kasey, Brown, Matthew F. D., Richey, John A.

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Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Au... von Vazquez, Michael L, Kaila, Neelu, Strohbach, Joseph W, Trzupek, John D, Brown, Matthew F, Flanagan, Mark E, Mitton-Fry, Mark J, Johnson, Timothy A, TenBrink, Ruth E, Arnold, Eric P, Basak, Arindrajit, Heasley, Steven E, Kwon, Soojin, Langille, Jonathan, Parikh, Mihir D, Griffin, Sarah H, Casavant, Jeffrey M, Duclos, Brian A, Fenwick, Ashley E, Harris, Thomas M, Han, Seungil, Caspers, Nicole, Dowty, Martin E, Yang, Xin, Banker, Mary Ellen, Hegen, Martin, Symanowicz, Peter T, Li, Li, Wang, Lu, Lin, Tsung H, Jussif, Jason, Clark, James D, Telliez, Jean-Baptiste, Robinson, Ralph P, Unwalla, Ray

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