Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity von Vincent, Benjamin M., Tardiff, Daniel F., Piotrowski, Jeff S., Aron, Rebecca, Lucas, Matthew C., Chung, Chee Yeun, Bacherman, Helene, Chen, YiQun, Pires, Michelle, Subramaniam, Radha, Doshi, Dimple B., Sadlish, Heather, Raja, Waseem K., Solís, Eric J., Khurana, Vikram, Le Bourdonnec, Bertrand, Scannevin, Robert H., Rhodes, Kenneth J.

Volltext

Rational Design of Highly Selective Spleen Tyrosine Kinase Inhibitors von Lucas, Matthew C., Goldstein, David M., Hermann, Johannes C., Kuglstatter, Andreas, Liu, Wenjian, Luk, Kin Chun, Padilla, Fernando, Slade, Michelle, Villaseñor, Armando G., Wanner, Jutta, Xie, Wenwei, Zhang, Xiaohu, Liao, Cheng

Volltext

Current and emerging therapies for Achondroplasia: The dawn of precision medicine von Dardenne, Etienne, Ishiyama, Noboru, Lin, Tai-An, Lucas, Matthew C

Volltext

Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors von Yang, Hanbiao, Hendricks, Robert T., Arora, Nidhi, Nitzan, Dov, Yee, Calvin, Lucas, Matthew C., Yang, Yanli, Fung, Amy, Rajyaguru, Sonal, Harris, Seth F., Leveque, Vincent J.P., Hang, Julie Q., Pogam, Sophie Le, Reuter, Deborah, Tavares, Gisele A.

Volltext

Targeting the SYK―BTK axis for the treatment of immunological and hematological disorders Recent progress and therapeutic perspectives von TAN, Seng-Lai, CHENG LIAO, LUCAS, Matthew C, STEVENSON, Christopher, DEMARTINO, Julie A

Volltext

Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta von Murray, Jeremy M, Sweeney, Zachary K, Chan, Bryan K, Balazs, Mercedesz, Bradley, Erin, Castanedo, Georgette, Chabot, Christine, Chantry, David, Flagella, Michael, Goldstein, David M, Kondru, Rama, Lesnick, John, Li, Jun, Lucas, Matthew C, Nonomiya, Jim, Pang, Jodie, Price, Stephen, Salphati, Laurent, Safina, Brian, Savy, Pascal P. A, Seward, Eileen M, Ultsch, Mark, Sutherlin, Daniel P

Volltext

Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition von Safina, Brian S, Baker, Stewart, Baumgardner, Matt, Blaney, Paul M, Chan, Bryan K, Chen, Yung-Hsiang, Cartwright, Matthew W, Castanedo, Georgette, Chabot, Christine, Cheguillaume, Arnaud J, Goldsmith, Paul, Goldstein, David M, Goyal, Bindu, Hancox, Timothy, Handa, Raj K, Iyer, Pravin S, Kaur, Jasmit, Kondru, Rama, Kenny, Jane R, Krintel, Sussie L, Li, Jun, Lesnick, John, Lucas, Matthew C, Lewis, Cristina, Mukadam, Sophie, Murray, Jeremy, Nadin, Alan J, Nonomiya, Jim, Padilla, Fernando, Palmer, Wylie S, Pang, Jodie, Pegg, Neil, Price, Steve, Reif, Karin, Salphati, Laurent, Savy, Pascal A, Seward, Eileen M, Shuttleworth, Stephen, Sohal, Sukhjit, Sweeney, Zachary K, Tay, Suzanne, Tivitmahaisoon, Parcharee, Waszkowycz, Bohdan, Wei, Binqing, Yue, Qin, Zhang, Chenghong, Sutherlin, Daniel P

Volltext

Pyrrolopyrazines as Selective Spleen Tyrosine Kinase Inhibitors von Padilla, Fernando, Bhagirath, Niala, Chen, Shaoqing, Chiao, Eric, Goldstein, David M, Hermann, Johannes C, Hsu, Jonathan, Kennedy-Smith, Joshua J, Kuglstatter, Andreas, Liao, Cheng, Liu, Wenjian, Lowrie, Lee E, Luk, Kin Chun, Lynch, Stephen M, Menke, John, Niu, Linghao, Owens, Timothy D, O-Yang, Counde, Railkar, Aruna, Schoenfeld, Ryan C, Slade, Michelle, Steiner, Sandra, Tan, Yun-Chou, Villaseñor, Armando G, Wang, Ce, Wanner, Jutta, Xie, Wenwei, Xu, Daigen, Zhang, Xiaohu, Zhou, Mingyan, Lucas, Matthew C

Volltext

Using Ovality to Predict Nonmutagenic, Orally Efficacious Pyridazine Amides as Cell Specific Spleen Tyrosine Kinase Inhibitors von Lucas, Matthew C, Bhagirath, Niala, Chiao, Eric, Goldstein, David M, Hermann, Johannes C, Hsu, Pei-Yuan, Kirchner, Stephan, Kennedy-Smith, Joshua J, Kuglstatter, Andreas, Lukacs, Christine, Menke, John, Niu, Linghao, Padilla, Fernando, Peng, Ying, Polonchuk, Liudmila, Railkar, Aruna, Slade, Michelle, Soth, Michael, Xu, Daigen, Yadava, Preeti, Yee, Calvin, Zhou, Mingyan, Liao, Cheng

Volltext

The first total synthesis of (±)-1-desoxyhypnophilin von Harrowven, David C, Lucas, Matthew C, Howes, Peter D

Volltext

Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf von Sutherlin, Daniel P., Baker, Stewart, Bisconte, Angelina, Blaney, Paul M., Brown, Anthony, Chan, Bryan K., Chantry, David, Castanedo, Georgette, DePledge, Paul, Goldsmith, Paul, Goldstein, David M., Hancox, Timothy, Kaur, Jasmit, Knowles, David, Kondru, Rama, Lesnick, John, Lucas, Matthew C., Lewis, Cristina, Murray, Jeremy, Nadin, Alan J., Nonomiya, Jim, Pang, Jodie, Pegg, Neil, Price, Steve, Reif, Karin, Safina, Brian S., Salphati, Laurent, Staben, Steven, Seward, Eileen M., Shuttleworth, Stephen, Sohal, Sukhjit, Sweeney, Zachary K., Ultsch, Mark, Waszkowycz, Bohdan, Wei, Binqing

Volltext

Palladium-catalyzed, heteroatom assisted, regioselective cyclizations von Krafft, Marie E, Lucas, Matthew C

Volltext

Targeting the SYK–BTK axis for the treatment of immunological and hematological disorders von Tan, Seng-Lai, Liao, Cheng, Lucas, Matthew C., Stevenson, Christopher, DeMartino, Julie A.

Volltext

2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression von Carter, David S., Cai, Hai-Ying, Lee, Eun Kyung, Iyer, Pravin S., Lucas, Matthew C., Roetz, Ralf, Schoenfeld, Ryan C., Weikert, Robert J.

Volltext

Design, synthesis, and biological evaluation of new monoamine reuptake inhibitors with potential therapeutic utility in depression and pain von Lucas, Matthew C., Weikert, Robert J., Carter, David S., Cai, Hai-Ying, Greenhouse, Robert, Iyer, Pravin S., Lin, Clara J., Lee, Eun Kyung, Madera, Ann Marie, Moore, Amy, Ozboya, Kerem, Schoenfeld, Ryan C., Steiner, Sandra, Zhai, Yansheng, Lynch, Stephen M.

Volltext

Microwave-enhanced rhodium-catalyzed conjugate-addition of aryl boronic acids to unprotected maleimides von Iyer, Pravin S., O’Malley, Meaghan M., Lucas, Matthew C.

Volltext

Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors von BANNWART, Linda M, CARTER, David S, LYNCH, Stephen M, MADERA, Ann Marie, MOORE, Amy, OZBOYA, Kerem, RAPTOVA, Lubica, ROETZ, Ralf, SCHOENFELD, Ryan C, STEIN, Karin Ann, STEINER, Sandra, VILLA, Marzia, CAI, Hai-Ying, WEIKERT, Robert J, YANSHENG ZHAI, CHOY, Jason C, GREENHOUSE, Robert, JAIME-FIGUEROA, Saul, LYER, Pravin S, LIN, Clara J, EUN KYUNG LEE, LUCAS, Matthew C

Volltext

The Mixed Meanings of Metaphors in Voir Dire von Lucas, Matthew C

Volltext

Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors von Lucas, Matthew C., Carter, David S., Cai, Hai-Ying, Lee, Eun Kyung, Schoenfeld, Ryan C., Steiner, Sandra, Villa, Marzia, Weikert, Robert J., Iyer, Pravin S.

Volltext

The synthesis of a natural product family: from debromoisolaurinterol to the aplysins von Harrowven, David C, Lucas, Matthew C, Howes, Peter D

Volltext