CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial von Cordoba, Shaun, Onuoha, Shimobi, Thomas, Simon, Pignataro, Daniela Soriano, Hough, Rachael, Ghorashian, Sara, Vora, Ajay, Bonney, Denise, Veys, Paul, Rao, Kanchan, Lucchini, Giovanna, Chiesa, Robert, Chu, Jan, Clark, Liz, Fung, Mei Mei, Smith, Koval, Peticone, Carlotta, Al-Hajj, Muhammad, Baldan, Vania, Ferrari, Mathieu, Srivastava, Saket, Jha, Ram, Arce Vargas, Frederick, Duffy, Kevin, Day, William, Virgo, Paul, Wheeler, Lucy, Hancock, Jeremy, Farzaneh, Farzin, Domning, Sabine, Zhang, Yiyun, Khokhar, Nushmia Z., Peddareddigari, Vijay G. R., Wynn, Robert, Pule, Martin, Amrolia, Persis J.

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Reply to: Oligoclonality of TRBC1 and TRBC2 in T cell lymphomas as mechanism of primary resistance to TRBC-directed CAR T cell therapies von Ferrari, Mathieu, Parekh, Farhaan, Maciocia, Paul, Horna, Pedro, Thomas, Simon, Sewell, Andrew K., Pule, Martin

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Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies von Ferrari, Mathieu, Righi, Matteo, Baldan, Vania, Wawrzyniecka, Patrycja, Bulek, Anna, Kinna, Alexander, Ma, Biao, Bughda, Reyisa, Akbar, Zulaikha, Srivastava, Saket, Gannon, Isaac, Robson, Mathew, Sillibourne, James, Jha, Ram, El-Kholy, Mohamed, Amin, Oliver Muhammad, Kokalaki, Evangelia, Banani, Mohammed Amin, Hussain, Rehan, Day, William, Lim, Wen Chean, Ghongane, Priyanka, Hopkins, Jade R., Jungherz, Dennis, Herling, Marco, Welin, Martin, Surade, Sachin, Dyson, Michael, McCafferty, John, Logan, Derek, Cordoba, Shaun, Thomas, Simon, Sewell, Andrew, Maciocia, Paul, Onuoha, Shimobi, Pule, Martin

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Exploration of T cell immune responses by expression of a dominant-negative SHP1 and SHP2 von Taylor, Julia, Bulek, Anna, Gannon, Isaac, Robson, Mathew, Kokalaki, Evangelia, Grothier, Thomas, McKenzie, Callum, El-Kholy, Mohamed, Stavrou, Maria, Traynor-White, Charlotte, Lim, Wen Chean, Panagiotou, Panagiota, Srivastava, Saket, Baldan, Vania, Sillibourne, James, Ferrari, Mathieu, Pule, Martin, Thomas, Simon

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A primer set for the rapid isolation of scFv fragments against cell surface antigens from immunised rats von Nannini, Francesco, Parekh, Farhaan, Wawrzyniecka, Patrycja, Mekkaoui, Leila, Righi, Matteo, Dastjerdi, Fatemeh V., Yeung, Jenny, Roddie, Claire, Bai, Yuchen, Ma, Biao, Ferrari, Mathieu, Onuoha, Shimobi, Chester, Kerry, Pule, Martin

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Combining phage display with SMRTbell next-generation sequencing for the rapid discovery of functional scFv fragments von Nannini, Francesco, Senicar, Lenart, Parekh, Farhaan, Kong, Khai J, Kinna, Alexander, Bughda, Reyisa, Sillibourne, James, Hu, Xihao, Ma, Biao, Bai, Yuchen, Ferrari, Mathieu, Pule, Martin A, Onuoha, Shimobi C

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Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis von Ferrari, Mathieu, Onuoha, Shimobi C, Fossati-Jimack, Liliane, Nerviani, Alessandra, Alves, Pedro L, Pagani, Sara, Deantonio, Cecilia, Colombo, Federico, Santoro, Claudio, Sblattero, Daniele, Pitzalis, Costantino

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Dual T-cell constant β chain (TRBC)1 and TRBC2 staining for the identification of T-cell neoplasms by flow cytometry von Horna, Pedro, Weybright, Matthew J., Ferrari, Mathieu, Jungherz, Dennis, Peng, YaYi, Akbar, Zulaikha, Tudor Ilca, F., Otteson, Gregory E., Seheult, Jansen N., Ortmann, Janosch, Shi, Min, Maciocia, Paul M., Herling, Marco, Pule, Martin A., Olteanu, Horatiu

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Limited efficacy of APRIL CAR in patients with multiple myeloma indicate challenges in the use of natural ligands for CAR T-cell therapy von Lee, Lydia, Lim, Wen Chean, Galas-Filipowicz, Daria, Fung, Kent, Taylor, Julia, Patel, Dominic, Akbar, Zulaikha, Alvarez Mediavilla, Elena, Wawrzyniecka, Patrycja, Shome, Debarati, Reijmers, Rogier M, Gregg, Trillian, Wood, Leigh, Day, William, Cerec, Virginie, Ferrari, Mathieu, Thomas, Simon, Cordoba, Shaun, Onuoha, Shimobi, Khokhar, Nushmia, Peddareddigari, Vijay, Al-Hajj, Muhammad, Cavet, Jim, Zweegman, Sonja, Rodriguez-Justo, Manuel, Yong, Kwee, Pule, Martin, Popat, Rakesh

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IκB Kinase ε Targets Interferon Regulatory Factor 1 in Activated T Lymphocytes von Sgarbanti, Marco, Marsili, Giulia, Remoli, Anna Lisa, Stellacci, Emilia, Mai, Antonello, Rotili, Dante, Perrotti, Edvige, Acchioni, Chiara, Orsatti, Roberto, Iraci, Nunzio, Ferrari, Mathieu, Borsetti, Alessandra, Hiscott, John, Battistini, Angela

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Optimised Method for the Production and Titration of Lentiviral Vectors Pseudotyped with the SARS-CoV-2 Spike von Mekkaoui, Leila, Bentley, Emma M, Ferrari, Mathieu, Lamb, Katarina, Ward, Katarzyna, Karattil, Rajeev, Akbar, Zulaikha, Bughda, Reyisa, Sillibourne, James, Onuoha, Shimobi, Mattiuzzo, Giada, Takeuchi, Yasuhiro, Pule, Martin

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Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR von Ghorashian, Sara, Kramer, Anne Marijn, Onuoha, Shimobi, Wright, Gary, Bartram, Jack, Richardson, Rachel, Albon, Sarah J., Casanovas-Company, Joan, Castro, Fernanda, Popova, Bilyana, Villanueva, Krystle, Yeung, Jenny, Vetharoy, Winston, Guvenel, Aleks, Wawrzyniecka, Patrycja A., Mekkaoui, Leila, Cheung, Gordon Weng-Kit, Pinner, Danielle, Chu, Jan, Lucchini, Giovanna, Silva, Juliana, Ciocarlie, Oana, Lazareva, Arina, Inglott, Sarah, Gilmour, Kimberly C., Ahsan, Gulrukh, Ferrari, Mathieu, Manzoor, Somayya, Champion, Kim, Brooks, Tony, Lopes, Andre, Hackshaw, Allan, Farzaneh, Farzin, Chiesa, Robert, Rao, Kanchan, Bonney, Denise, Samarasinghe, Sujith, Goulden, Nicholas, Vora, Ajay, Veys, Paul, Hough, Rachael, Wynn, Robert, Pule, Martin A., Amrolia, Persis J.

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Going with the flow: harnessing the power of the vasculature for targeted therapy in rheumatoid arthritis von Ferrari, Mathieu, Onuoha, Shimobi C., Pitzalis, Costantino

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Characterization of a Novel ACE2-Based Therapeutic with Enhanced Rather than Reduced Activity against SARS-CoV-2 Variants von Ferrari, Mathieu, Mekkaoui, Leila, Ilca, F Tudor, Akbar, Zulaikha, Bughda, Reyisa, Lamb, Katarina, Ward, Katarzyna, Parekh, Farhaan, Karattil, Rajeev, Allen, Christopher, Wu, Philip, Baldan, Vania, Mattiuzzo, Giada, Bentley, Emma M, Takeuchi, Yasuhiro, Sillibourne, James, Datta, Preeta, Kinna, Alexander, Pule, Martin, Onuoha, Shimobi C

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Dual targeting of CD19 and CD22 against B-ALL using a novel high-sensitivity aCD22 CAR von Kokalaki, Evangelia, Ma, Biao, Ferrari, Mathieu, Grothier, Thomas, Hazelton, Warren, Manzoor, Somayya, Costu, Eren, Taylor, Julia, Bulek, Anna, Srivastava, Saket, Gannon, Isaac, Jha, Ram, Gealy, Rosalind, Stanczuk, Lukas, Rizou, Tatiana, Robson, Mathew, El-Kholy, Mohamed, Baldan, Vania, Righi, Matteo, Sillibourne, James, Thomas, Simon, Onuoha, Shimobi, Cordoba, Shaun, Pule, Martin

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TRBC1-CAR T cell therapy in peripheral T cell lymphoma: a phase 1/2 trial von Cwynarski, Kate, Iacoboni, Gloria, Tholouli, Eleni, Menne, Tobias, Irvine, David A., Balasubramaniam, Nivetha, Wood, Leigh, Shang, Justin, Xue, Eric, Zhang, Yiyun, Basilico, Silvia, Neves, Margarida, Raymond, Meera, Scott, Ian, El-Kholy, Mohamed, Jha, Ram, Dainton-Smith, Heather, Hussain, Rehan, Day, William, Ferrari, Mathieu, Thomas, Simon, Lilova, Koki, Brugger, Wolfram, Marafioti, Teresa, Lao-Sirieix, Pierre, Maciocia, Paul, Pule, Martin

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Anti-CD21 Chimeric Antigen Receptor (CAR)-T Cells for T Cell Acute Lymphoblastic Leukaemia (T-ALL) von Maciocia, Nicola C, Burley, Amy, Nannini, Francesco, Wawrzyniecka, Patrycja, Neves, Margarida, Karpanasamy, Thaneswari, Ferrari, Mathieu, Marafioti, Teresa, Onuoha, Shimobi, Khwaja, Asim, Maciocia, Paul M, Pule, Martin

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Rational Design of Antirheumatic Prodrugs Specific for Sites of Inflammation von Onuoha, Shimobi C., Ferrari, Mathieu, Sblattero, Daniele, Pitzalis, Costantino

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Designer Small-Molecule Control System Based on Minocycline-Induced Disruption of Protein–Protein Interaction von Jha, Ram, Kinna, Alexander, Hotblack, Alastair, Bughda, Reyisa, Bulek, Anna, Gannon, Isaac, Ilca, Tudor, Allen, Christopher, Lamb, Katarina, Dolor, Abigail, Scott, Ian, Parekh, Farhaan, Sillibourne, James, Cordoba, Shaun, Onuoha, Shimobi, Thomas, Simon, Ferrari, Mathieu, Pule, Martin

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A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency von Leach, Adam, Ilca, F. Tudor, Akbar, Zulaikha, Ferrari, Mathieu, Bentley, Emma M., Mattiuzzo, Giada, Onuoha, Shimobi, Miller, Ami, Ali, Hanif, Rabbitts, Terence H.

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