Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension von McLendon, Jared M., Joshi, Sachindra R., Sparks, Jeff, Matar, Majed, Fewell, Jason G., Abe, Kohtaro, Oka, Masahiko, McMurtry, Ivan F., Gerthoffer, William T.

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Strong immunogenicity & protection in mice with PlaCCine: A COVID-19 DNA vaccine formulated with a functional polymer von Sood, Subeena, Matar, Majed M., Kim, Jessica, Kinsella, Meredyth, Rayavara, Kempaiah, Signer, Olivia, Henderson, John, Rogers, Joseph, Chawla, Bhavna, Narvaez, Brandon, Van Ry, Alex, Kar, Swagata, Arnold, Austin, Rice, Jennifer S., Smith, Alanna M., Su, Daishui, Sparks, Jeff, Le Goff, Corinne, Boyer, Jean D., Anwer, Khursheed

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Synthetic tumor networks for screening drug delivery systems von Prabhakarpandian, Balabhaskar, Shen, Ming-Che, Nichols, Joseph B, Garson, Charles J, Mills, Ivy R, Matar, Majed M, Fewell, Jason G, Pant, Kapil

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Treatment of disseminated ovarian cancer using nonviral interleukin-12 gene therapy delivered intraperitoneally von Fewell, Jason G., Matar, Majed M., Rice, Jennifer S., Brunhoeber, Elaine, Slobodkin, Gregory, Pence, Casey, Worker, Miranda, Lewis, Danny H., Anwer, Khursheed

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Abstract 2078: Interleukin-12 gene therapy in combination with bevacizumab and pegylated liposomal doxorubicin for treatment of disseminated ovarian cancer von Fewell, Jason G., Matar, Majed M., Rice, Jennifer, McClure, Diane, Brunhoeber, Elaine, Sparks, Jeff, Greenleaf, Stefanie, Smith, Kelley, Anwer, Khursheed

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Delivery of siRNA to the Mouse Lung via a Functionalized Lipopolyamine von Polach, Kevin J, Matar, Majed, Rice, Jennifer, Slobodkin, Gregory, Sparks, Jeff, Congo, Richard, Rea-Ramsey, Angela, McClure, Diane, Brunhoeber, Elaine, Krampert, Monika, Schuster, Andrea, Jahn-Hofmann, Kerstin, John, Matthias, Vornlocher, Hans-Peter, Fewell, Jason G, Anwer, Khursheed, Geick, Anke

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Synthesis and application of a non-viral gene delivery system for immunogene therapy of cancer von Fewell, Jason G., Matar, Majed, Slobodkin, Gregory, Han, Sang-Oh, Rice, Jennifer, Hovanes, Bruce, Lewis, Danny H., Anwer, Khursheed

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A safety and efficacy study of local delivery of interleukin-12 transgene by PPC polymer in a model of experimental glioma von Sonabend, Adam M, Velicu, Simona, Ulasov, Ilya V, Han, Yu, Tyler, Betty, Brem, Henry, Matar, Majed M, Fewell, Jason G, Anwer, Khursheed, Lesniak, Maciej S

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Up‐regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmona... von Aghamohammadzadeh, Reza, Zhang, Ying‐Yi, Stephens, Thomas E., Arons, Elena, Zaman, Paula, Polach, Kevin J., Matar, Majed, Yung, Lai‐Ming, Yu, Paul B., Bowman, Frederick P., Opotowsky, Alexander R., Waxman, Aaron B., Loscalzo, Joseph, Leopold, Jane A., Maron, Bradley A.

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Genetic and hypoxic alterations of the microRNA‐210‐ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension von White, Kevin, Lu, Yu, Annis, Sofia, Hale, Andrew E, Chau, B Nelson, Dahlman, James E, Hemann, Craig, Opotowsky, Alexander R, Vargas, Sara O, Rosas, Ivan, Perrella, Mark A, Osorio, Juan C, Haley, Kathleen J, Graham, Brian B, Kumar, Rahul, Saggar, Rajan, Saggar, Rajeev, Wallace, W Dean, Ross, David J, Khan, Omar F, Bader, Andrew, Gochuico, Bernadette R, Matar, Majed, Polach, Kevin, Johannessen, Nicolai M, Prosser, Haydn M, Anderson, Daniel G, Langer, Robert, Zweier, Jay L, Bindoff, Laurence A, Systrom, David, Waxman, Aaron B, Jin, Richard C, Chan, Stephen Y

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Abstract 4440: Efficacy of Gen-1, an interleukin-12 immune gene therapy, at different dose frequencies von Sood, Subeena, Boyer, Jean D., Kim, Jessica, Matar, Majed M., Signer, Olivia, Rice, Jennifer S., Smith, Alanna M., Borys, Nicholas, Anwer, Khursheed

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Nanoparticle Delivery of Anti-inflammatory LNA Oligonucleotides Prevents Airway Inflammation in a HDM Model of Asthma von Ramelli, Sabrina C., Comer, Brian S., McLendon, Jared M., Sandy, Lydia L., Ferretti, Andrew P., Barrington, Robert, Sparks, Jeff, Matar, Majed, Fewell, Jason, Gerthoffer, William T.

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Abstract 12714: Aldosterone Activates Raptor to Promote Pulmonary Artery Smooth Muscle Cell Proliferation and Pulmonary Arterial Hypertension von Stephens, Thomas E, Arons, Elena, Zhang, Ying-Yi, Zaman, Paula, Aghamohammadzadeh, Reza, Polach, Kevin J, Matar, Majed, Brown, Marcel G, Loscalzo, Joseph, Leopold, Jane A, Maron, Bradley A

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Versatile cationic lipids for siRNA delivery von Sparks, Jeff, Slobodkin, Gregory, Matar, Majed, Congo, Richard, Ulkoski, David, Rea-Ramsey, Angela, Pence, Casey, Rice, Jennifer, McClure, Diane, Polach, Kevin J., Brunhoeber, Elaine, Wilkinson, Leslie, Wallace, Kirby, Anwer, Khursheed, Fewell, Jason G.

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Protein Mediated Transport of Biologically Active RNA to the Extracellular Space Provides Inhibition of Cell Signaling Events von Polach, Kevin J, Wilkinson, Leslie, Brunhoeber, Elaine, Pettigrew, Amy, Wallace, Kirby, Sparks, Jeff, Matar, Majed, Rice, Jennifer, Anwer, Khursheed, Fewell, Jason G

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Abstract B17: Inhibition of lung tumor progression in a metastatic mouse model following intravenous delivery of siRNA nanocomplexes von Fewell, Jason G., Anwer, Khursheed, Polach, Kevin, Matar, Majed, Rice, Jennifer, Rea-Ramsey, Angela, Sparks, Jeff, McClure, Diane, Pence, Casey, Brunhoeber, Elaine, Wilkinson, Leslie

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Abstract 4995: Lung specific target gene inhibition following intravenous delivery of siRNA nanocomplexes von Fewell, Jason, Sparks, Jeff, Congo, Richard, Slobodkin, Gregory, Rea-Ramsey, Angela, Pence, Casey, Matar, Majed, McClure, Diane, Rice, Jennifer, Brunhoeber, Elaine, Wilkinson, Leslie, Anwer, Khursheed, Polach, Kevin

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Genetic and hypoxic alterations of the micro RNA ‐210‐ ISCU 1/2 axis promote iron–sulfur deficiency and pulmonary hypertension von White, Kevin, Lu, Yu, Annis, Sofia, Hale, Andrew E, Chau, B Nelson, Dahlman, James E, Hemann, Craig, Opotowsky, Alexander R, Vargas, Sara O, Rosas, Ivan, Perrella, Mark A, Osorio, Juan C, Haley, Kathleen J, Graham, Brian B, Kumar, Rahul, Saggar, Rajan, Saggar, Rajeev, Wallace, W Dean, Ross, David J, Khan, Omar F, Bader, Andrew, Gochuico, Bernadette R, Matar, Majed, Polach, Kevin, Johannessen, Nicolai M, Prosser, Haydn M, Anderson, Daniel G, Langer, Robert, Zweier, Jay L, Bindoff, Laurence A, Systrom, David, Waxman, Aaron B, Jin, Richard C, Chan, Stephen Y

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Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension von White, Kevin, Lu, Yu, Annis, Sofia, Hale, Andrew E, Chau, B Nelson, Dahlman, James E, Hemann, Craig, Opotowsky, Alexander R, Vargas, Sara O, Rosas, Ivan, Perrella, Mark A, Osorio, Juan C, Haley, Kathleen J, Graham, Brian B, Kumar, Rahul, Saggar, Rajan, Saggar, Rajeev, Wallace, W Dean, Ross, David J, Khan, Omar F, Bader, Andrew, Gochuico, Bernadette R, Matar, Majed, Polach, Kevin, Johannessen, Nicolai M, Prosser, Haydn M, Anderson, Daniel G, Langer, Robert, Zweier, Jay L, Bindoff, Laurence A, Systrom, David, Waxman, Aaron B, Jin, Richard C, Chan, Stephen Y

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Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension von White, Kevin, Lu, Yu, Annis, Sofia, Hale, Andrew E, Chau, B. Nelson, Dahlman, James E, Hemann, Craig, Opotowsky, Alexander R, Vargas, Sara O, Rosas, Ivan, Perrella, Mark A, Osorio, Juan C, Haley, Kathleen J, Graham, Brian B, Kumar, Rahul, Saggar, Rajan, Saggar, Rajeev, Wallace, W. Dean, Ross, David J, Khan, Omar F, Bader, Andrew, Gochuico, Bernadette R, Matar, Majed, Polach, Kevin, Johannessen, Nicolai, Prosser, Haydn M, Anderson, Daniel G, Langer, Robert, Zweier, Jay L, Bindoff, Laurence, Systrom, David, Waxman, Aaron B, Jin, Richard C, Chan, Stephen Y

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