Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development von Wittman, Mark D, Carboni, Joan M, Yang, Zheng, Lee, Francis Y, Antman, Melissa, Attar, Ricardo, Balimane, Praveen, Chang, Chiehying, Chen, Cliff, Discenza, Lorell, Frennesson, David, Gottardis, Marco M, Greer, Ann, Hurlburt, Warren, Johnson, Walter, Langley, David R, Li, Aixin, Li, Jianqing, Liu, Peiying, Mastalerz, Harold, Mathur, Arvind, Menard, Krista, Patel, Karishma, Sack, John, Sang, Xiaopeng, Saulnier, Mark, Smith, Daniel, Stefanski, Kevin, Trainor, George, Velaparthi, Upender, Zhang, Guifen, Zimmermann, Kurt, Vyas, Dolatrai M

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9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors von Zimmermann, Kurt, Sang, Xiaopeng, Mastalerz, Harold A., Johnson, Walter L., Zhang, Guifen, Liu, Qingjie, Batt, Douglas, Lombardo, Louis J., Vyas, Dinesh, Trainor, George L., Tokarski, John S., Lorenzi, Matthew V., You, Dan, Gottardis, Marco M., Lippy, Jonathan, Khan, Javed, Sack, John S., Purandare, Ashok V.

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Pyrrolo[1,2- f]triazines as JAK2 inhibitors: Achieving potency and selectivity for JAK2 over JAK3 von Harikrishnan, Lalgudi S., Kamau, Muthoni G., Wan, Honghe, Inghrim, Jennifer A., Zimmermann, Kurt, Sang, Xiaopeng, Mastalerz, Harold A., Johnson, Walter L., Zhang, Guifen, Lombardo, Louis J., Poss, Michael A., Trainor, George L., Tokarski, John S., Lorenzi, Matthew V., You, Dan, Gottardis, Marco M., Baldwin, Kathy F., Lippy, Jonathan, Nirschl, David S., Qiu, Ruhui, Miller, Arthur V., Khan, Javed, Sack, John S., Purandare, Ashok V.

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Novel pyrrolo[2,1- f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases von Fink, Brian E., Norris, Derek, Mastalerz, Harold, Chen, Ping, Goyal, Bindu, Zhao, Yufen, Kim, Soong-Hoon, Vite, Gregory D., Lee, Francis Y., Zhang, Hongjian, Oppenheimer, Simone, Tokarski, John S., Wong, Tai W., Gavai, Ashvinikumar V.

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Monoclonal Antibody Conjugates of Doxorubicin Prepared with Branched Peptide Linkers:  Inhibition of Aggregation by Methoxytriethyleneglycol Chains von King, H. Dalton, Dubowchik, Gene M, Mastalerz, Harold, Willner, David, Hofstead, Sandra J, Firestone, Raymond A, Lasch, Shirley J, Trail, Pamela A

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Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic Acid, (3S)-3-Morpholinylmethyl Ester... von Gavai, Ashvinikumar V, Fink, Brian E, Fairfax, David J, Martin, Gregory S, Rossiter, Lana M, Holst, Christian L, Kim, Soong-Hoon, Leavitt, Kenneth J, Mastalerz, Harold, Han, Wen-Ching, Norris, Derek, Goyal, Bindu, Swaminathan, Shankar, Patel, Bharat, Mathur, Arvind, Vyas, Dolatrai M, Tokarski, John S, Yu, Chiang, Oppenheimer, Simone, Zhang, Hongjian, Marathe, Punit, Fargnoli, Joseph, Lee, Francis Y, Wong, Tai W, Vite, Gregory D

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The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor von Kiefer, Susan E., Chang, ChiehYing J., Kimura, S. Roy, Gao, Mian, Xie, Dianlin, Zhang, Yaqun, Zhang, Guifen, Gill, Martin B., Mastalerz, Harold, Thompson, Lorin A., Cacace, Angela M., Sheriff, Steven

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New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases von Mastalerz, Harold, Chang, Ming, Chen, Ping, Dextraze, Pierre, Fink, Brian E., Gavai, Ashvinikumar, Goyal, Bindu, Han, Wen-Ching, Johnson, Walter, Langley, David, Lee, Francis Y., Marathe, Punit, Mathur, Arvind, Oppenheimer, Simone, Ruediger, Edward, Tarrant, James, Tokarski, John S., Vite, Gregory D., Vyas, Dolatrai M., Wong, Henry, Wong, Tai W., Zhang, Hongjian, Zhang, Guifen

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5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases von Mastalerz, Harold, Chang, Ming, Chen, Ping, Fink, Brian E., Gavai, Ashvinikumar, Han, Wen-Ching, Johnson, Walter, Langley, David, Lee, Francis Y., Leavitt, Kenneth, Marathe, Punit, Norris, Derek, Oppenheimer, Simone, Sleczka, Bogdan, Tarrant, James, Tokarski, John S., Vite, Gregory D., Vyas, Dolatrai M., Wong, Henry, Wong, Tai W., Zhang, Hongjian, Zhang, Guifen

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Synthesis of a hybrid analog of the esperamicin and dynemicin cores von Mastalerz, Harold, Doyle, Terrence W, Kadow, John F, Vyas, Dolatrai M

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Doxorubicin immunoconjugates containing bivalent, lysosomally-Cleavable dipeptide linkages von Dubowchik, Gene M, Radia, Shilpa, Mastalerz, Harold, Walker, Michael A, Firestone, Raymond A, Dalton King, H, Hofstead, Sandra J, Willner, David, Lasch, Shirley J, Trail, Pamela A

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Pyrrolotriazine-5-carboxylate ester inhibitors of EGFR and HER2 protein tyrosine kinases and a novel one-pot synthesis of C-4 subsitituted pyrrole-2,3-dicarboxylate diesters von Mastalerz, Harold, Gavai, Ashvinikumar V, Fink, Brian, Struzynski, Charles, Tarrant, James, Vite, Gregory D, Wong, Tai W, Zhang, Guifen, Vyas, Dolatrai M

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THE SYNTHESIS, ANTIBACTERIAL, AND β-LACTAMASE INHIBITORY ACTIVITY OF A NOVEL ASPARENOMYCIN ANALOG von BOUTHILLIER, GILLES, MASTALERZ, HAROLD, MENARD, MARCEL, FUNG-TOMC, JOAN, GRADELSKI, ELIZABETH

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Synthesis of a 4.beta.-(Hydroxymethyl)carbapenem von Mastalerz, Harold, Menard, Marcel

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Synthesis of a 4β-(hydroxymethyl)carbapenem von MASTALERZ, H, MENARD, M

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ISOFURANONE COMPOUNDS USEFUL AS HPK1 INHIBITORS von KUMI, Godwin Kwame, MASTALERZ, Harold A, WITTMAN, Mark D, ARAUJO, Erika M. V, DEGNAN, Andrew P, CHEN, Yan, ZHANG, Guifen, HILL, Matthew D, DASGUPTA, Bireshwar, PEARCE, Bradley C

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ISOFURANONE COMPOUNDS USEFUL AS HPK1 INHIBITORS von Chen, Yan, Mastalerz, Harold A, Degnan, Andrew P, Pearce, Bradley C, Dasgupta, Bireshwar, Kumi, Godwin Kwame, Hill, Matthew D, Wittman, Mark D, Zhang, Guifen, Araujo, Erika M.V

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Intermediates useful in preparing certain pyrrolotriazine compounds and process for making such intermediates von ZHANG GUIFEN, MASTALERZ HAROLD

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Synthesis of a 4β-carboxyethyl derivative of thienamycin von Bouthillier, Gilles, Mastalerz, Harold, Menard, Marcel

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SUBSTITUTED DIHYDRO-1H-PYRROLO[3,2-C]PYRIDIN-4(5H)-ONES AS RIPK3 INHIBITORS von MASTALERZ Harold, HART Amy C, BROWN Gregory D, PITTS William J, GUO Junqing

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