sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH von Hall, Katherine C., Bernier, Sylvie G., Jacobson, Sarah, Liu, Guang, Zhang, Ping Y., Sarno, Renee, Catanzano, Victoria, Currie, Mark G., Masferrer, Jaime L.

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Anti-PDGF-B monoclonal antibody reduces liver fibrosis development von Ogawa, Shinji, Ochi, Takashi, Shimada, Hideaki, Inagaki, Kazuyuki, Fujita, Isami, Nii, Aisuke, Moffat, Mark A., Katragadda, Madan, Violand, Bernard N., Arch, Robert H., Masferrer, Jaime L.

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Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease von Zimmer, Daniel P, Shea, Courtney M, Tobin, Jenny V, Tchernychev, Boris, Germano, Peter, Sykes, Kristie, Banijamali, Ali R, Jacobson, Sarah, Bernier, Sylvie G, Sarno, Renee, Carvalho, Andrew, Chien, Yueh-Tyng, Graul, Regina, Buys, Emmanuel S, Jones, Juli E, Wakefield, James D, Price, Gavrielle M, Chickering, Jennifer G, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L

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Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation von Arhancet, Graciela B., Walker, Daniel P., Metz, Sue, Fobian, Yvette M., Heasley, Steven E., Carter, Jeffrey S., Springer, John R., Jones, Darin E., Hayes, Michael J., Shaffer, Alexander F., Jerome, Gina M., Baratta, Michael T., Zweifel, Ben, Moore, William M., Masferrer, Jaime L., Vazquez, Michael L.

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Cyclooxygenase-2 Is Overexpressed in Human Cervical Cancer von KULKARNI, Swati, RADER, Janet S, FAN ZHANG, LIAPIS, Helen, KOKI, Alane T, MASFERRER, Jaime L, SUBBARAMAIAH, Kotha, DANNENBERG, Andrew J

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Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor von Mbalaviele, Gabriel, Pauley, Adele M., Shaffer, Alexander F., Zweifel, Ben S., Mathialagan, Sumathy, Mnich, Stephen J., Nemirovskiy, Olga V., Carter, Jeff, Gierse, James K., Wang, Jane L., Vazquez, Michael L., Moore, William M., Masferrer, Jaime L.

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Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit von Flores-Costa, Roger, Duran-Güell, Marta, Casulleras, Mireia, López-Vicario, Cristina, Alcaraz-Quiles, José, Diaz, Alba, Lozano, Juan J., Titos, Esther, Hall, Katherine, Sarno, Renee, Masferrer, Jaime L., Clària, Joan

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Pharmacologic Evaluation of Sulfasalazine, FTY720, and Anti-IL-12/23p40 in a TNBS-Induced Crohn’s Disease Model von Radi, Zaher A., Heuvelman, Deborah M., Masferrer, Jaime L., Benson, Ericka L.

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Soluble guanylate cyclase stimulator praliciguat attenuates inflammation, fibrosis, and end-organ damage in the Dahl model of cardiorenal failure von Shea, Courtney M, Price, Gavrielle M, Liu, Guang, Sarno, Renee, Buys, Emmanuel S, Currie, Mark G, Masferrer, Jaime L

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Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats von Banijamali, Ali R., Carvalho, Andrew E., Wakefield, James D., Germano, Peter, Barden, Timothy C., Tobin, Jenny V., Zimmer, Daniel P., Masferrer, Jaime L., Profy, Albert T., Currie, Mark G., Todd Milne, G.

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Selective Inhibition of Inducible Cyclooxygenase 2 in vivo is Antiinflammatory and Nonulcerogenic von MASFERRER, J. L, ZWEIFEL, B. S, MANNING, P. T, HAUSER, S. D, LEAHY, K. M, SMITH, W. G, ISAKSON, P. C, SEIBERT, K

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Synergy between celecoxib and radiotherapy results from inhibition of cyclooxygenase-2-derived prostaglandin E2, a survival factor for tumor and associated vasculature von DAVIS, Thomas W, O'NEAL, Janet M, PAGEL, Mark D, ZWEIFEL, Ben S, MEHTA, Pramod P, HEUVELMAN, Deborah M, MASFERRER, Jaime L

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The soluble guanylate cyclase stimulator IW‐1973 prevents inflammation and fibrosis in experimental non‐alcoholic steatohepatitis von Flores‐Costa, Roger, Alcaraz‐Quiles, José, Titos, Esther, López‐Vicario, Cristina, Casulleras, Mireia, Duran‐Güell, Marta, Rius, Bibiana, Diaz, Alba, Hall, Katherine, Shea, Courtney, Sarno, Renee, Currie, Mark, Masferrer, Jaime L, Clària, Joan

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Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso‐occlusion and nephropathy in mouse models of sickle cell disease von Tchernychev, Boris, Li, Huihui, Lee, Sung‐Kyun, Gao, Xin, Ramanarasimhaiah, Raghunath, Liu, Guang, Hall, Katherine C., Bernier, Sylvie G., Jones, Juli E., Feil, Susanne, Feil, Robert, Buys, Emmanuel S., Graul, Regina M., Frenette, Paul S., Masferrer, Jaime L.

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SGLT2 inhibition potentiates the cardiovascular, renal, and metabolic effects of sGC stimulation in hypertensive rats with prolonged exposure to high-fat diet von Reverte, Virginia, Rodriguez, Francisca, Oltra, Lidia, Moreno, Juan M, Llinás, María T, Shea, Courtney M, Schwartzkopf, Chad D, Buys, Emmanuel S, Masferrer, Jaime L, Salazar, F Javier

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Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic... von Tobin, Jenny V., Zimmer, Daniel P., Shea, Courtney, Germano, Peter, Bernier, Sylvie G., Liu, Guang, Long, Kim, Miyashiro, Joy, Ranganath, Sheila, Jacobson, Sarah, Tang, Kim, Im, G-Yoon Jamie, Sheppeck, James, Moore, Joel D., Sykes, Kristine, Wakefield, James, Sarno, Renee, Banijamali, Ali R., Profy, Albert T., Milne, G. Todd, Currie, Mark G., Masferrer, Jaime L.

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Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells von Liu, Guang, Shea, Courtney M., Jones, Juli E., Price, Gavrielle M., Warren, William, Lonie, Elisabeth, Yan, Shu, Currie, Mark G., Profy, Albert T., Masferrer, Jaime L., Zimmer, Daniel P.

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The Cyclooxygenase-2 Inhibitor, Celecoxib, Prevents the Development of Mammary Tumors in HER-2/neu Mice von LANZA-JACOBY, Susan, MILLER, Sheldon, FLYNN, John, GALLATIG, Kathleen, DASKALAKIS, Constantine, MASFERRER, Jaime L, ZWEIFEL, Ben S, SEMBHI, Harjeet, RUSSO, Irma H

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Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors von MASFERRER, J. L, LEAHY, K. M, KOKI, A. T, ZWEIFEL, B. S, SETTLE, S. L, WOERNER, B. M, EDWARDS, D. A, FLICKINGER, A. G, MOORE, R. J, SEIBERT, K

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Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo von LEAHY, Kathleen M, ORNBERG, Richard L, YU WANG, ZWEIFEL, Ben S, KOKI, Alane T, MASFERRER, Jaime L

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