Structural basis for RNA replication by the hepatitis C virus polymerase von Appleby, Todd C., Perry, Jason K., Murakami, Eisuke, Barauskas, Ona, Feng, Joy, Cho, Aesop, Fox, David, Wetmore, Diana R., McGrath, Mary E., Ray, Adrian S., Sofia, Michael J., Swaminathan, S., Edwards, Thomas E.

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Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase δ von Somoza, John R., Koditek, David, Villaseñor, Armando G., Novikov, Nikolai, Wong, Melanie H., Liclican, Albert, Xing, Weimei, Lagpacan, Leanna, Wang, Ruth, Schultz, Brian E., Papalia, Giuseppe A., Samuel, Dharmaraj, Lad, Latesh, McGrath, Mary E.

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A structural role for hormone in the thyroid hormone receptor von Wagner, Richard L, Apriletti, James W, McGrath, Mary E, West, Brian L, Baxter, John D, Fletterick, Robert J

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Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3‑Kinase (PI3K) β Inhibitor von Chandrasekhar, Jayaraman, Dick, Ryan, Van Veldhuizen, Joshua, Koditek, David, Lepist, Eve-Irene, McGrath, Mary E, Patel, Leena, Phillips, Gary, Sedillo, Kassandra, Somoza, John R, Therrien, Joseph, Till, Nicholas A, Treiberg, Jennifer, Villaseñor, Armando G, Zherebina, Yelena, Perreault, Stephane

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Discovery of a Phosphoinositide 3‑Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selecti... von Perreault, Stephane, Chandrasekhar, Jayaraman, Cui, Zhi-Hua, Evarts, Jerry, Hao, Jia, Kaplan, Joshua A, Kashishian, Adam, Keegan, Kathleen S, Kenney, Thomas, Koditek, David, Lad, Latesh, Lepist, Eve-Irene, McGrath, Mary E, Patel, Leena, Phillips, Bart, Therrien, Joseph, Treiberg, Jennifer, Yahiaoui, Anella, Phillips, Gary

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Discovery of Orally Efficacious Phosphoinositide 3‑Kinase δ Inhibitors with Improved Metabolic Stability von Patel, Leena, Chandrasekhar, Jayaraman, Evarts, Jerry, Forseth, Kristen, Haran, Aaron C, Ip, Carmen, Kashishian, Adam, Kim, Musong, Koditek, David, Koppenol, Sandy, Lad, Latesh, Lepist, Eve-Irene, McGrath, Mary E, Perreault, Stephane, Puri, Kamal D, Villaseñor, Armando G, Somoza, John R, Steiner, Bart H, Therrien, Joseph, Treiberg, Jennifer, Phillips, Gary

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The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain von Somoza, John R, Ho, Joseph D, Luong, Christine, Ghate, Manjiri, Sprengeler, Paul A, Mortara, Kyle, Shrader, William D, Sperandio, David, Chan, Hedy, McGrath, Mary E, Katz, Bradley A

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2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors von Patel, Leena, Chandrasekhar, Jayaraman, Evarts, Jerry, Haran, Aaron C, Ip, Carmen, Kaplan, Joshua A, Kim, Musong, Koditek, David, Lad, Latesh, Lepist, Eve-Irene, McGrath, Mary E, Novikov, Nikolai, Perreault, Stephane, Puri, Kamal D, Somoza, John R, Steiner, Bart H, Stevens, Kirk L, Therrien, Joseph, Treiberg, Jennifer, Villaseñor, Armando G, Yeung, Arthur, Phillips, Gary

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Discovery of an Atropisomeric PI3Kβ Selective Inhibitor through Optimization of the Hinge Binding Motif von Perreault, Stephane, Arjmand, Fatima, Chandrasekhar, Jayaraman, Hao, Jia, Keegan, Kathleen S., Koditek, David, Lepist, Eve-Irene, Matson, Clinton K., McGrath, Mary E., Patel, Leena, Sedillo, Kassandra, Therrien, Joseph, Till, Nicholas A., Tomkinson, Adrian, Treiberg, Jennifer, Zherebina, Yelena, Phillips, Gary

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Visualizing the Molecular Interactions of a Nucleotide Analog, GS-9148, with HIV-1 Reverse Transcriptase–DNA Complex von Lansdon, Eric B., Samuel, Dharmaraj, Lagpacan, Leanna, Brendza, Katherine M., White, Kirsten L., Hung, Magdeleine, Liu, Xiaohong, Boojamra, Constantine G., Mackman, Richard L., Cihlar, Tomas, Ray, Adrian S., McGrath, Mary E., Swaminathan, S.

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Crystal Structure of Phenylmethanesulfonyl Fluoride-Treated Human Chymase at 1.9 Å von McGrath, Mary E, Mirzadegan, Tara, Schmidt, Brian F

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Identification of a potent and selective non-basic cathepsin K inhibitor von Li, Chun Sing, Deschenes, Denis, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Kimmel, Donald. B., Léger, Serge, Massé, Frédéric, McGrath, Mary E., McKay, Daniel J., Percival, M. David, Riendeau, Denis, Rodan, Sevgi B., Thérien, Michel, Truong, Vouy-Linh, Wesolowski, Gregg, Zamboni, Robert, Black, W. Cameron

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Peptide Ketobenzoxazole Inhibitors Bound to Cathepsin K von McGrath, Mary E, Sprengeler, Paul A, Hill, Craig M, Martichonok, Valeri, Cheung, Harry, Somoza, John R, Palmer, James T, Janc, James W

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THE LYSOSOMAL CYSTEINE PROTEASES von McGrath, Mary E

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Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214 von McGrath, Mary E, Vasquez, John R, Craik, Charles S, Yang, A. S, Honig, Barry, Fletterick, Robert J

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Structure-Guided Design of Peptide-Based Tryptase Inhibitors von McGrath, Mary E, Sprengeler, Paul A, Hirschbein, Bernard, Somoza, John R, Lehoux, Isabelle, Janc, James W, Gjerstad, Erik, Graupe, Michael, Estiarte, Angeles, Venkataramani, Chandru, Liu, Yang, Yee, Robb, Ho, Joseph D, Green, Michael J, Lee, Chang-Sun, Liu, Liang, Tai, Vincent, Spencer, Jeffrey, Sperandio, David, Katz, Bradley A

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Dissecting and Designing Inhibitor Selectivity Determinants at the S1 Site Using an Artificial Ala190 Protease (Ala190 uPA) von Katz, Bradley A., Luong, Christine, Ho, Joseph D., Somoza, John R., Gjerstad, Erik, Tang, Jie, Williams, Steven R., Verner, Erik, Mackman, Richard L., Young, Wendy B., Sprengeler, Paul A., Chan, Hedy, Mortara, Kyle, Janc, James W., McGrath, Mary E.

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Crystal Structure of Human Cathepsin V von Somoza, John R, Zhan, Hangjun, Bowman, Krista K, Yu, Lily, Mortara, Kyle D, Palmer, James T, Clark, James M, McGrath, Mary E

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Production of crystallizable human chymase from a Bacillus subtilis system von McGrath, Mary E, Osawa, A.Edward, Barnes, Michael G, Clark, James M, Mortara, Kyle D, Schmidt, Brian F

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Design of novel, potent, and selective human β-tryptase inhibitors based on α-keto-[1,2,4]-oxadiazoles von Lee, Chang-Sun, Liu, Weili, Sprengeler, Paul A., Somoza, John R., Janc, James W., Sperandio, David, Spencer, Jeffrey R., Green, Michael J., McGrath, Mary E.

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