Targeted inhibition of the COP9 signalosome for treatment of cancer von Schlierf, Anita, Altmann, Eva, Quancard, Jean, Jefferson, Anne B., Assenberg, René, Renatus, Martin, Jones, Matthew, Hassiepen, Ulrich, Schaefer, Michael, Kiffe, Michael, Weiss, Andreas, Wiesmann, Christian, Sedrani, Richard, Eder, Jörg, Martoglio, Bruno

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Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease von Weihofen, Andreas, Binns, Kathleen, Lemberg, Marius K., Ashman, Keith, Martoglio, Bruno

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The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain von Beisner, Daniel R, Langerak, Petra, Parker, Albert E, Dahlberg, Carol, Otero, Francella J, Sutton, Sue E, Poirot, Laurent, Barnes, Whitney, Young, Michael A, Niessen, Sherry, Wiltshire, Tim, Bodendorf, Ursula, Martoglio, Bruno, Cravatt, Benjamin, Cooke, Michael P

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Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18 von Prod'homme, Virginie, Tomasec, Peter, Cunningham, Charles, Lemberg, Marius K, Stanton, Richard J, McSharry, Brian P, Wang, Eddie C Y, Cuff, Simone, Martoglio, Bruno, Davison, Andrew J, Braud, Véronique M, Wilkinson, Gavin W G

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The Signal Peptide of the Mouse Mammary Tumor Virus Rem Protein Is Released from the Endoplasmic Reticulum Membrane and Accumulates in Nucleoli von Dultz, Elisa, Hildenbeutel, Markus, Martoglio, Bruno, Hochman, Jacob, Dobberstein, Bernhard, Kapp, Katja

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Protein Folding during Cotranslational Translocation in the Endoplasmic Reticulum von Kowarik, Michael, Küng, Stephanie, Martoglio, Bruno, Helenius, Ari

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Intramembrane Proteolysis of Signal Peptides: An Essential Step in the Generation of HLA-E Epitopes von Lemberg, Marius K, Bland, Felicity A, Weihofen, Andreas, Braud, Veronique M, Martoglio, Bruno

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Consensus Analysis of Signal Peptide Peptidase and Homologous Human Aspartic Proteases Reveals Opposite Topology of Catalytic Domains Compared with Presenilins von Friedmann, Elena, Lemberg, Marius K., Weihofen, Andreas, Dev, Kumlesh K., Dengler, Uwe, Rovelli, Giorgio, Martoglio, Bruno

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Core Protein of Pestiviruses Is Processed at the C Terminus by Signal Peptide Peptidase von Heimann, Manuela, Roman-Sosa, Gleyder, Martoglio, Bruno, Thiel, Heinz-Jürgen, Rümenapf, Till

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Release of Signal Peptide Fragments into the Cytosol Requires Cleavage in the Transmembrane Region by a Protease Activity That Is Specifically Blocked by a Novel Cysteine Protease... von Weihofen, Andreas, Lemberg, Marius K., Ploegh, Hidde L., Bogyo, Matthew, Martoglio, Bruno

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Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway von Ottis, Philipp, Palladino, Chiara, Thienger, Phillip, Britschgi, Adrian, Heichinger, Christian, Berrera, Marco, Julien-Laferriere, Alice, Roudnicky, Filip, Kam-Thong, Tony, Bischoff, James R, Martoglio, Bruno, Pettazzoni, Piergiorgio

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Drosophila signal peptide peptidase is an essential protease for larval development von Casso, David J, Tanda, Soichi, Biehs, Brian, Martoglio, Bruno, Kornberg, Thomas B

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The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer von Martoglio, Bruno, Hofmann, Michael W, Brunner, Josef, Dobberstein, Bernhard

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Requirement of the Proteasome for the Trimming of Signal Peptide-derived Epitopes Presented by the Nonclassical Major Histocompatibility Complex Class I Molecule HLA-E von Bland, Felicity A., Lemberg, Marius K., McMichael, Andrew J., Martoglio, Bruno, Braud, Veronique M.

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Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides von Weihofen, Andreas, Martoglio, Bruno

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Signal sequences: more than just greasy peptides von Martoglio, Bruno, Dobberstein, Bernhard

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Preclinical Characterization of a Next-Generation Brain Permeable, Paradox Breaker BRAF Inhibitor von Wichmann, Jürgen, Rynn, Caroline, Friess, Thomas, Petrig-Schaffland, Jeannine, Kornacker, Martin, Handl, Cornelia, Emmenegger, Jasmin, Eckmann, Jan, Herting, Frank, Frances, Nicolas, Hunziker, Daniel, Krummenacher, Daniela, Rüttinger, Dominik, Ribeiro, Alison, Bacac, Marina, Brigo, Alessandro, Hewings, David S, Dummer, Reinhard, Levesque, Mitchell P, Schnetzler, Gabriel, Martoglio, Bruno, Bischoff, James R, Pettazzoni, Piergiorgio

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Direct and GTP-Dependent Interaction of ADP Ribosylation Factor 1 with Coatomer Subunit β von Zhao, Liyun, Helms, J. Bernd, Brugger, Britta, Harter, Cordula, Martoglio, Bruno, Graf, Roland, Brunner, Josef, Wieland, Felix T.

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Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib von Obst-Sander, Ulrike, Ricci, Antonio, Kuhn, Bernd, Friess, Thomas, Koldewey, Philipp, Kuglstatter, Andreas, Hewings, David, Goergler, Annick, Steiner, Sandra, Rueher, Daniel, Imhoff, Marie-Paule, Raschetti, Noemi, Marty, Hans-Peter, Dietzig, Aline, Rynn, Caroline, Ehler, Andreas, Burger, Dominique, Kornacker, Martin, Schaffland, Jeannine Petrig, Herting, Frank, Pao, William, Bischoff, James R., Martoglio, Bruno, Alice Nagel, Yvonne, Jaeschke, Georg

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Requirements for Signal Peptide Peptidase-Catalyzed Intramembrane Proteolysis von Lemberg, Marius K, Martoglio, Bruno

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