Parsing the Interferon Transcriptional Network and Its Disease Associations von Mostafavi, Sara, Yoshida, Hideyuki, Moodley, Devapregasan, LeBoité, Hugo, Rothamel, Katherine, Raj, Towfique, Ye, Chun Jimmie, Chevrier, Nicolas, Zhang, Shen-Ying, Feng, Ting, Lee, Mark, Casanova, Jean-Laurent, Clark, James D., Hegen, Martin, Telliez, Jean-Baptiste, Hacohen, Nir, De Jager, Philip L., Regev, Aviv, Mathis, Diane, Benoist, Christophe

Volltext

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1‑((2S,5R)‑5-((7H‑Pyrrolo[2,3‑d]pyrimidin-4-yl)­amino)-2-methylpiperidin-1-yl)­prop-2-en-1-one (PF-06651600) Allowing for the I... von Thorarensen, Atli, Dowty, Martin E, Banker, Mary Ellen, Juba, Brian, Jussif, Jason, Lin, Tsung, Vincent, Fabien, Czerwinski, Robert M, Casimiro-Garcia, Agustin, Unwalla, Ray, Trujillo, John I, Liang, Sidney, Balbo, Paul, Che, Ye, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Leung, Louis, Yang, Xin, Soucy, Sarah, Hegen, Martin, Coe, Jotham, Langille, Jonathan, Vajdos, Felix, Chrencik, Jill, Telliez, Jean-Baptiste

Volltext

Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function von Su, Zhenwei, Brooks, Jonathan, Pelker, Jeffrey, Andreyeva, Tatyana, Sobon, Hanna, Gifford, Roger, Powers, Matthew, Wang, Jing, Dower, Corey, Hegen, Martin, Messing, Dean, Sheehan, Alfredo Darmanin, Brennan, Joseph J

Volltext

Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition von Dowty, Martin E., Lin, Tsung H., Jesson, Michael I., Hegen, Martin, Martin, David A., Katkade, Vaibhav, Menon, Sujatha, Telliez, Jean‐Baptiste

Volltext

Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease von Karmele, Erik P., Pasricha, Trisha S., Ramalingam, Thirumalai R., Thompson, Robert W., Gieseck, Richard L., Knilans, Kayla J., Hegen, Martin, Farmer, Mark, Jin, Fang, Kleinman, Aaron, Hinds, David A., Almeida Pereira, Thiago, de Queiroz Prado, Rafael, Bing, Nan, Tchistiakova, Lioudmila, Kasaian, Marion T., Wynn, Thomas A., Vannella, Kevin M.

Volltext

Antibodies specific for carbamylated proteins precede the onset of clinical symptoms in mice with collagen induced arthritis von Stoop, Jeroen N, Liu, Bi-Sheng, Shi, Jing, Jansen, Diahann T S L, Hegen, Martin, Huizinga, Tom W J, Trouw, Leendert A, Toes, René E M

Volltext

MAPKAP Kinase 2-Deficient Mice Are Resistant to Collagen-Induced Arthritis von Hegen, Martin, Gaestel, Matthias, Nickerson-Nutter, Cheryl L, Lin, Lih-Ling, Telliez, Jean-Baptiste

Volltext

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-... von Fensome, Andrew, Ambler, Catherine M, Arnold, Eric, Banker, Mary Ellen, Brown, Matthew F, Chrencik, Jill, Clark, James D, Dowty, Martin E, Efremov, Ivan V, Flick, Andrew, Gerstenberger, Brian S, Gopalsamy, Ariamala, Hayward, Matthew M, Hegen, Martin, Hollingshead, Brett D, Jussif, Jason, Knafels, John D, Limburg, David C, Lin, David, Lin, Tsung H, Pierce, Betsy S, Saiah, Eddine, Sharma, Raman, Symanowicz, Peter T, Telliez, Jean-Baptiste, Trujillo, John I, Vajdos, Felix F, Vincent, Fabien, Wan, Zhao-Kui, Xing, Li, Yang, Xiaojing, Yang, Xin, Zhang, Liying

Volltext

Pharmacokinetic, Biodistribution, and Biophysical Profiles of TNF Nanobodies Conjugated to Linear or Branched Poly(ethylene glycol) von Vugmeyster, Yulia, Entrican, Clifford A, Joyce, Alison P, Lawrence-Henderson, Rosemary F, Leary, Beth A, Mahoney, Christopher S, Patel, Himakshi K, Raso, Stephen W, Olland, Stephane H, Hegen, Martin, Xu, Xin

Volltext

Utility of animal models for identification of potential therapeutics for rheumatoid arthritis von Hegen, M, Keith, J C, Collins, M, Nickerson-Nutter, C L

Volltext

RORγt inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating γδ-T cells von Mortier, Céline, Gracey, Eric, Coudenys, Julie, Manuello, Teddy, Decruy, Tine, Maelegheer, Margaux, Stappers, Flore, Gilis, Elisabeth, Gaublomme, Djoere, Van Hoorebeke, Luc, Van Welden, Sophie, Ambler, Catherine, Hegen, Martin, Symanowicz, Peter, Steyn, Stefan, Berstein, Gabriel, Elewaut, Dirk, Venken, Koen

Volltext

Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Au... von Vazquez, Michael L, Kaila, Neelu, Strohbach, Joseph W, Trzupek, John D, Brown, Matthew F, Flanagan, Mark E, Mitton-Fry, Mark J, Johnson, Timothy A, TenBrink, Ruth E, Arnold, Eric P, Basak, Arindrajit, Heasley, Steven E, Kwon, Soojin, Langille, Jonathan, Parikh, Mihir D, Griffin, Sarah H, Casavant, Jeffrey M, Duclos, Brian A, Fenwick, Ashley E, Harris, Thomas M, Han, Seungil, Caspers, Nicole, Dowty, Martin E, Yang, Xin, Banker, Mary Ellen, Hegen, Martin, Symanowicz, Peter T, Li, Li, Wang, Lu, Lin, Tsung H, Jussif, Jason, Clark, James D, Telliez, Jean-Baptiste, Robinson, Ralph P, Unwalla, Ray

Volltext

Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 von Su, Zhenwei, Brooks, Jonathan, Pelker, Jeffrey, Andreyeva, Tatyana, Sobon, Hanna, Gifford, Roger, Powers, Matthew, Wang, Jing, Dower, Corey, Hegen, Martin, Messing, Dean, Sheehan, Alfredo Darmanin, Brennan, Joseph J

Volltext

Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases von Gerstenberger, Brian S, Ambler, Catherine, Arnold, Eric P, Banker, Mary-Ellen, Brown, Matthew F, Clark, James D, Dermenci, Alpay, Dowty, Martin E, Fensome, Andrew, Fish, Susan, Hayward, Matthew M, Hegen, Martin, Hollingshead, Brett D, Knafels, John D, Lin, David W, Lin, Tsung H, Owen, Dafydd R, Saiah, Eddine, Sharma, Raman, Vajdos, Felix F, Xing, Li, Yang, Xiaojing, Yang, Xin, Wright, Stephen W

Volltext

The Interleukin‐1 Receptor–Associated Kinase 4 Inhibitor PF‐06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical... von Winkler, Aaron, Sun, Weiyong, De, Saurav, Jiao, Aiping, Sharif, M. Nusrat, Symanowicz, Peter T., Athale, Shruti, Shin, Julia H., Wang, Ju, Jacobson, Bruce A., Ramsey, Simeon J., Dower, Ken, Andreyeva, Tatyana, Liu, Heng, Hegen, Martin, Homer, Bruce L., Brodfuehrer, Joanne, Tilley, Mera, Gilbert, Steven A., Danto, Spencer I., Beebe, Jean J., Barnes, Betsy J., Pascual, Virginia, Lin, Lih‐Ling, Kilty, Iain, Fleming, Margaret, Rao, Vikram R.

Volltext

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition von Telliez, Jean-Baptiste, Dowty, Martin E, Wang, Lu, Jussif, Jason, Lin, Tsung, Li, Li, Moy, Erick, Balbo, Paul, Li, Wei, Zhao, Yajuan, Crouse, Kimberly, Dickinson, Caitlyn, Symanowicz, Peter, Hegen, Martin, Banker, Mary Ellen, Vincent, Fabien, Unwalla, Ray, Liang, Sidney, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Yang, Xin, Bauman, Jonathan, Trujillo, John I, Casimiro-Garcia, Agustin, Vajdos, Felix F, Leung, Louis, Geoghegan, Kieran F, Quazi, Amira, Xuan, Dejun, Jones, Lyn, Hett, Erik, Wright, Katherine, Clark, James D, Thorarensen, Atli

Volltext

Network pharmacology of JAK inhibitors von Moodley, Devapregasan, Yoshida, Hideyuki, Mostafavi, Sara, Asinovski, Natasha, Ortiz-Lopez, Adriana, Symanowicz, Peter, Telliez, Jean-Baptiste, Hegen, Martin, Clark, James D., Mathis, Diane, Benoist, Christophe

Volltext

ROR gamma t inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating gamma delta-T cells von Mortier, Céline, Gracey, Eric, Coudenys, Julie, Manuello, Teddy, Decruy, Tine, Maelegheer, Margaux, Stappers, Flore, Gilis, Elisabeth, Gaublomme, Djoere, Van Hoorebeke, Luc, Van Welden, Sophie, Ambler, Catherine, Hegen, Martin, Symanowicz, Peter, Steyn, Stefan, Berstein, Gabriel, Elewaut, Dirk, Venken, Koen

Volltext

A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+... von Li, Wei, Crouse, Kimberly K, Alley, Jennifer, Frisbie, Richard K, Fish, Susan C, Andreyeva, Tatyana A, Reed, Lori A, Thorn, Mitchell, DiMaggio, Giovanni, Donovan, Carol B, Bennett, Donald, Garren, Jeonifer, Oziolor, Elias, Qian, Jesse, Newman, Leah, Vargas, Amanda P., Kumpf, Steven W., Steyn, Stefan J, Schnute, Mark E, Thorarensen, Atli, Hegen, Martin, Stevens, Erin, Collinge, Mark, Lanz, Thomas A, Vincent, Fabien, Vincent, Michael S, Berstein, Gabriel

Volltext

A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6 +... von Li, Wei, Crouse, Kimberly K, Alley, Jennifer, Frisbie, Richard K, Fish, Susan C, Andreyeva, Tatyana A, Reed, Lori A, Thorn, Mitchell, DiMaggio, Giovanni, Donovan, Carol B, Bennett, Donald, Garren, Jeonifer, Oziolor, Elias, Qian, Jesse, Newman, Leah, Vargas, Amanda P, Kumpf, Steven W, Steyn, Stefan J, Schnute, Mark E, Thorarensen, Atli, Hegen, Martin, Stevens, Erin, Collinge, Mark, Lanz, Thomas A, Vincent, Fabien, Vincent, Michael S, Berstein, Gabriel

Volltext