Discovery of Nivasorexant (ACT-539313): The First Selective Orexin‑1 Receptor Antagonist (SO1RA) Investigated in Clinical Trials von Williams, Jodi T., Bolli, Martin H., Brotschi, Christine, Sifferlen, Thierry, Steiner, Michel A., Treiber, Alexander, Gatfield, John, Boss, Christoph

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Distinct ETA receptor binding mode of macitentan as determined by site directed mutagenesis von Gatfield, John, Mueller Grandjean, Celia, Bur, Daniel, Bolli, Martin H, Nayler, Oliver

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The Discovery of N‑[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]‑N′‑propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor Ant... von Bolli, Martin H, Boss, Christoph, Binkert, Christoph, Buchmann, Stephan, Bur, Daniel, Hess, Patrick, Iglarz, Marc, Meyer, Solange, Rein, Josiane, Rey, Markus, Treiber, Alexander, Clozel, Martine, Fischli, Walter, Weller, Thomas

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A functional BCR in human IgA and IgM plasma cells von Pinto, Dora, Montani, Erica, Bolli, Martin, Garavaglia, Guido, Sallusto, Federica, Lanzavecchia, Antonio, Jarrossay, David

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From bosentan (Tracleer®) to macitentan (Opsumit®): The medicinal chemistry perspective von Boss, Christoph, Bolli, Martin H., Gatfield, John

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Discovery of the Novel, Orally Active, and Selective LPA1 Receptor Antagonist ACT-1016-0707 as a Preclinical Candidate for the Treatment of Fibrotic Diseases von Lescop, Cyrille, Birker, Magdalena, Brotschi, Christine, Bürki, Cédric, Morrison, Keith, Froidevaux, Sylvie, Delahaye, Stéphane, Nayler, Oliver, Bolli, Martin H.

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Discovery of a Novel Orally Active, Selective LPA Receptor Type 1 Antagonist, 4‑(4-(2-Isopropylphenyl)-4-((2-methoxy-4-methylphenyl)carbamoyl)piperidin-1-yl)-4-oxobutanoic Acid, wi... von Lescop, Cyrille, Brotschi, Christine, Williams, Jodi T., Sager, Christoph P., Birker, Magdalena, Morrison, Keith, Froidevaux, Sylvie, Delahaye, Stéphane, Nayler, Oliver, Bolli, Martin H.

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The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation von Piali, Luca, Froidevaux, Sylvie, Hess, Patrick, Nayler, Oliver, Bolli, Martin H, Schlosser, Eva, Kohl, Christopher, Steiner, Beat, Clozel, Martine

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The Discovery of Macitentan - A Standard Medicinal Chemistry Program? von Bolli, Martin H

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Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure-activity-relationship, and sleep-promoting properties in rats von Brotschi, Christine, Bolli, Martin H, Gatfield, John, Roch, Catherine, Sifferlen, Thierry, Treiber, Alexander, Williams, Jodi T, Boss, Christoph

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High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes von Coto-Llerena, Mairene, Ercan, Caner, Kancherla, Venkatesh, Taha-Mehlitz, Stephanie, Eppenberger-Castori, Serenella, Soysal, Savas D, Ng, Charlotte K Y, Bolli, Martin, von Flüe, Markus, Nicolas, Guillaume P, Terracciano, Luigi M, Fani, Melpomeni, Piscuoglio, Salvatore

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Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure–Activity Relationships, and Sleep‐Promoting Properties in Rats von Brotschi, Christine, Roch, Catherine, Gatfield, John, Treiber, Alexander, Williams, Jodi T., Sifferlen, Thierry, Heidmann, Bibia, Jenck, Francois, Bolli, Martin H., Boss, Christoph

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From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs von Brotschi, Christine, Bolli, Martin H., Gatfield, John, Heidmann, Bibia, Jenck, Francois, Roch, Catherine, Sifferlen, Thierry, Treiber, Alexander, Williams, Jodi T., Boss, Christoph

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From laparoscopic to robotic-assisted Heller myotomy for achalasia in a single high-volume visceral surgery center: postoperative outcomes and quality of life von Gass, Jörn-Markus, Cron, Lucien, Mongelli, Francesco, Tartanus, Justyna, Angehrn, Fiorenzo Valente, Neuschütz, Kerstin, von Flüe, Markus, Fourie, Lana, Steinemann, Daniel, Bolli, Martin

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Practical Synthesis of a S1P Receptor 1 Agonist via a Guareschi–Thorpe Reaction von Schmidt, Gunther, Bolli, Martin H, Lescop, Cyrille, Abele, Stefan

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Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling von Gatfield, John, Monnier, Lucile, Studer, Rolf, Bolli, Martin H., Steiner, Beat, Nayler, Oliver

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Local ablative therapies and the effect on antitumor immune responses in pancreatic cancer – A review von Erdem, Suna, Narayanan, Jayanth Shankara, Worni, Mathias, Bolli, Martin, White, Rebekah R.

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Anatomic versus non‐anatomic liver resection for hepatocellular carcinoma—A European multicentre cohort study in cirrhotic and non‐cirrhotic patients von Zeindler, Jasmin, Hess, Gabriel Fridolin, Heesen, Maximilian, Aegerter, Noa, Reber, Cornelia, Schmitt, Andreas Michael, Muenst, Simone, Bolli, Martin, Soysal, Savas Deniz, Kollmar, Otto

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Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach von Heidmann, Bibia, Gatfield, John, Roch, Catherine, Treiber, Alexander, Tortoioli, Simone, Brotschi, Christine, Williams, Jodi T., Bolli, Martin H., Abele, Stefan, Sifferlen, Thierry, Jenck, François, Boss, Christoph

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Novel S1P1 receptor agonists – Part 5: From amino-to alkoxy-pyridines von Bolli, Martin H., Lescop, Cyrille, Birker, Magdalena, de Kanter, Ruben, Hess, Patrick, Kohl, Christopher, Nayler, Oliver, Rey, Markus, Sieber, Patrick, Velker, Jörg, Weller, Thomas, Steiner, Beat

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