ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor von Tse, Christin, Shoemaker, Alexander R, Adickes, Jessica, Anderson, Mark G, Chen, Jun, Jin, Sha, Johnson, Eric F, Marsh, Kennan C, Mitten, Michael J, Nimmer, Paul, Roberts, Lisa, Tahir, Stephen K, Xiao, Yu, Yang, Xiufen, Zhang, Haichao, Fesik, Stephen, Rosenberg, Saul H, Elmore, Steven W

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Venetoclax pharmacokinetics in participants with end‐stage renal disease undergoing haemodialysis von Noorani, Behnam, Menon, Rajeev M., Chen, Xin, Marsh, Kennan C., Huang, Weize, Gupta, Shelly, Dobkowska, Edyta, Marbury, Thomas, Salem, Ahmed Hamed

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Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins von Park, Cheol-Min, Bruncko, Milan, Adickes, Jessica, Bauch, Joy, Ding, Hong, Kunzer, Aaron, Marsh, Kennan C, Nimmer, Paul, Shoemaker, Alexander R, Song, Xiaohong, Tahir, Stephen K, Tse, Christin, Wang, Xilu, Wendt, Michael D, Yang, Xiufen, Zhang, Haichao, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W

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A Phase-I pharmacokinetic, safety and food-effect study on flubentylosin, a novel analog of Tylosin-A having potent anti-Wolbachia and antifilarial activity von Alami, Negar, Carter, David C, Kwatra, Nisha V, Zhao, Weihan, Snodgrass, Linda, Porcalla, Ariel R, Klein, Cheri E, Cohen, Daniel E, Gallenberg, Loretta, Neenan, Melina, Carr, Robert A, Marsh, Kennan C, Kempf, Dale J

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Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer von Penning, Thomas D, Zhu, Gui-Dong, Gandhi, Viraj B, Gong, Jianchun, Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Johnson, Eric F, Donawho, Cherrie K, Frost, David J, Bontcheva-Diaz, Velitchka, Bouska, Jennifer J, Osterling, Donald J, Olson, Amanda M, Marsh, Kennan C, Luo, Yan, Giranda, Vincent L

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Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study von McCarthy, James S, Prof, Lotharius, Julie, PhD, Rückle, Thomas, PhD, Chalon, Stephan, MD, Phillips, Margaret A, Prof, Elliott, Suzanne, PhD, Sekuloski, Silvana, PhD, Griffin, Paul, MD, Ng, Caroline L, PhD, Fidock, David A, Prof, Marquart, Louise, PhD, Williams, Noelle S, PhD, Gobeau, Nathalie, PhD, Bebrevska, Lidiya, PhD, Rosario, Maria, PhD, Marsh, Kennan, PhD, Möhrle, Jörg J, Dr

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UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria von Brunschwig, Christel, Lawrence, Nina, Taylor, Dale, Abay, Efrem, Njoroge, Mathew, Basarab, Gregory S, Le Manach, Claire, Paquet, Tanya, Cabrera, Diego Gonzàlez, Nchinda, Aloysius T, de Kock, Carmen, Wiesner, Lubbe, Denti, Paolo, Waterson, David, Blasco, Benjamin, Leroy, Didier, Witty, Michael J, Donini, Cristina, Duffy, James, Wittlin, Sergio, White, Karen L, Charman, Susan A, Jiménez-Díaz, Maria Belén, Angulo-Barturen, Iñigo, Herreros, Esperanza, Gamo, Francisco Javier, Rochford, Rosemary, Mancama, Dalu, Coetzer, Theresa L, van der Watt, Mariëtte E, Reader, Janette, Birkholtz, Lyn-Marie, Marsh, Kennan C, Solapure, Suresh M, Burke, John E, McPhail, Jacob A, Vanaerschot, Manu, Fidock, David A, Fish, Paul V, Siegl, Peter, Smith, Dennis A, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Silue, Kigbafori D, Street, Leslie J, Chibale, Kelly

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Assembling Pharma Resources to Tackle Diseases of Underserved Populations von Kempf, Dale J., Marsh, Kennan C.

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Translation of In Vitro Transport Inhibition Studies to Clinical Drug-Drug Interactions for Glecaprevir and Pibrentasvir von Kosloski, Matthew P, Bow, Daniel A J, Kikuchi, Ryota, Wang, Haoyu, Kim, Elaine J, Marsh, Kennan, Mensa, Federico, Kort, Jens, Liu, Wei

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Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis von Hulverson, Matthew A, Choi, Ryan, Schaefer, Deborah A, Betzer, Dana P, McCloskey, Molly C, Whitman, Grant R, Huang, Wenlin, Lee, Sangun, Pranata, Andy, McLeod, Malcolm D, Marsh, Kennan C, Kempf, Dale J, LeRoy, Bruce E, Zafiratos, Mark T, Bielinski, Aimee L, Hackman, Robert C, Ojo, Kayode K, Arnold, Samuel L M, Barrett, Lynn K, Tzipori, Saul, Riggs, Michael W, Fan, Erkang, Van Voorhis, Wesley C

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Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers von Salem, Ahmed Hamed, Tao, Zhi-Fu, Bueno, Orlando F., Chen, Jie, Chen, Shuang, Edalji, Rohinton, Elmore, Steven W., Fournier, Keith M., Harper, Kaid C., Hong, Richard, Jenkins, Gary J., Ji, Jianguo, Judge, Russell A., Kalvass, John C., Klix, Russell C., Ku, Yi-Yin, Leverson, Joel D., Marks, Richard A., Marsh, Kennan C., Menon, Rajeev M., Park, Chang H., Phillips, Darren C., Pu, Yu-Ming, Rosenberg, Saul H., Sanzgiri, Yeshwant D., Sheikh, Ahmad Y., Shi, Yi, Stolarik, Deanne, Suleiman, Ahmed A., Wang, Xilu, Zhang, Geoff G. Z., Catron, Nathaniel D., Souers, Andrew J.

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Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models von SHOEMAKER, Alex R, MITTEN, Michael J, BAUCH, Joy, MARSH, Kennan, TAHIR, Steven K, XIUFENYANG, TSE, Christin, FESIK, Stephen W, ROSENBERG, Saul H, ELMORE, Steven W, ADICKES, Jessica, ACKLER, Scott, REFICI, Marion, FERGUSON, Debra, OLEKSIJEW, Anatol, O'CONNOR, Jacqueline M, BAOLE WANG, FROST, David J

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Metabolite profiling of foslevodopa/foscarbidopa in plasma of healthy human participants by LC‐HRMS indicates no major differences compared to administration of levodopa/carbidopa... von Savaryn, John P., Smith, Richard L., Rosebraugh, Matthew, Neenan, Melina, Burton, Richard, Marsh, Kennan, Wagner, David

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Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor von Zhao, Gang, Souers, Andrew J, Voorbach, Martin, Falls, H. Doug, Droz, Brian, Brodjian, Sevan, Lau, Yau Yi, Iyengar, Rajesh R, Gao, Ju, Judd, Andrew S, Wagaw, Seble H, Ravn, Matthew M, Engstrom, Kenneth M, Lynch, John K, Mulhern, Mathew M, Freeman, Jennifer, Dayton, Brian D, Wang, Xiaojun, Grihalde, Nelson, Fry, Dennis, Beno, David W. A, Marsh, Kennan C, Su, Zhi, Diaz, Gilbert J, Collins, Christine A, Sham, Hing, Reilly, Regina M, Brune, Michael E, Kym, Philip R

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In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae von Hübner, Marc P, Koschel, Marianne, Struever, Dominique, Nikolov, Venelin, Frohberger, Stefan J, Ehrens, Alexandra, Fendler, Martina, Johannes, Iliana, von Geldern, Thomas W, Marsh, Kennan, Turner, Joseph D, Taylor, Mark J, Ward, Stephen A, Pfarr, Kenneth, Kempf, Dale J, Hoerauf, Achim

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High drug load, stable, manufacturable and bioavailable fenofibrate formulations in mesoporous silica: a comparison of spray drying versus solvent impregnation methods von Hong, Shiqi, Shen, Shoucang, Tan, David Cheng Thiam, Ng, Wai Kiong, Liu, Xueming, Chia, Leonard S. O., Irwan, Anastasia W., Tan, Reginald, Nowak, Steven A, Marsh, Kennan, Gokhale, Rajeev

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Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A von DeGoey, David A., Betebenner, David A., Grampovnik, David J., Liu, Dachun, Pratt, John K., Tufano, Michael D., He, Wenping, Krishnan, Preethi, Pilot-Matias, Tami J., Marsh, Kennan C., Molla, Akhteruzzaman, Kempf, Dale J., Maring, Clarence J.

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In vivo preliminary investigations of the effects of the benzimidazole anthelmintic drug flubendazole on rat embryos and fetuses von Longo, Monica, Zanoncelli, Sara, Messina, Monica, Scandale, Ivan, Mackenzie, Charles, Geary, Timothy, Marsh, Kennan, Lindley, David, Mazué, Guy

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Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats von Lynch, James J., Rossignol, Emilie, Moehrle, Joerg J., Van Vleet, Terry R., Marsh, Kennan C., Parman, Toufan, Mirsalis, Jon, Ottinger, Sean E., Segreti, Jason A., Rao, Mohan, Mittelstadt, Scott W.

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Discovery of N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibito... von Dai, Yujia, Hartandi, Kresna, Ji, Zhiqin, Ahmed, Asma A, Albert, Daniel H, Bauch, Joy L, Bouska, Jennifer J, Bousquet, Peter F, Cunha, George A, Glaser, Keith B, Harris, Christopher M, Hickman, Dean, Guo, Jun, Li, Junling, Marcotte, Patrick A, Marsh, Kennan C, Moskey, Maria D, Martin, Ruth L, Olson, Amanda M, Osterling, Donald J, Pease, Lori J, Soni, Niru B, Stewart, Kent D, Stoll, Vincent S, Tapang, Paul, Reuter, David R, Davidsen, Steven K, Michaelides, Michael R

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