The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity von Maurer, Mark F., Lewis, Katherine E., Kuijper, Joseph L., Ardourel, Dan, Gudgeon, Chelsea J., Chandrasekaran, Siddarth, Mudri, Sherri L., Kleist, Kayla N., Navas, Chris, Wolfson, Martin F., Rixon, Mark W., Swanson, Ryan, Dillon, Stacey R., Levin, Steven D., Kimbung, Yengo Raymond, Akutsu, Masato, Logan, Derek T., Walse, Björn, Swiderek, Kristine M., Peng, Stanford L.

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TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection von Chew, Glen M, Fujita, Tsuyoshi, Webb, Gabriela M, Burwitz, Benjamin J, Wu, Helen L, Reed, Jason S, Hammond, Katherine B, Clayton, Kiera L, Ishii, Naoto, Abdel-Mohsen, Mohamed, Liegler, Teri, Mitchell, Brooks I, Hecht, Frederick M, Ostrowski, Mario, Shikuma, Cecilia M, Hansen, Scott G, Maurer, Mark, Korman, Alan J, Deeks, Steven G, Sacha, Jonah B, Ndhlovu, Lishomwa C

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Interleukin 20: Discovery, Receptor Identification, and Role in Epidermal Function von Blumberg, Hal, Conklin, Darrell, Xu, WenFeng, Grossmann, Angelika, Brender, Ty, Carollo, Susan, Eagan, Maribeth, Foster, Don, Haldeman, Betty A, Hammond, Angie, Haugen, Harald, Jelinek, Laura, Kelly, James D, Madden, Karen, Maurer, Mark F, Parrish-Novak, Julia, Prunkard, Donna, Sexson, Shannon, Sprecher, Cindy, Waggie, Kim, West, Jim, Whitmore, Theodore E, Yao, Lena, Kuechle, Melanie K, Dale, Beverly A, Chandrasekher, Yasmin A

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Significance of Sesamoid Ossification in Peroneus Longus Tendon Ruptures von Maurer, Mark, DPM, Lehrman, Jeffrey, DPM

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33 Development of a clinical ex vivo assay for the assessment of therapeutic CD28 costimulatory pathway engagement von Gudgeon, Chelsea, Maurer, Mark, Means, Gary, Mudri, Sherri, Blanchfield, Lori, Yang, Jing, Dillon, Stacey, Holland, Pamela, Goldberg, Zelanna, Peng, Stanford

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PD-1 blockade enhances elotuzumab efficacy in mouse tumor models von Bezman, Natalie A., Jhatakia, Amy, Kearney, Alper Y., Brender, Ty, Maurer, Mark, Henning, Karla, Jenkins, Misty R., Rogers, Amy J., Neeson, Paul J., Korman, Alan J., Robbins, Michael D., Graziano, Robert F.

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Generation and characterization of human anti-human IL-21 neutralizing monoclonal antibodies von Maurer, Mark F., Garrigues, Ursula, Jaspers, Stephen R., Meengs, Brent, Rixon, Mark W., Stevens, Brenda L., Lewis, Kenneth B., Julien, Susan H., Bukowski, Thomas R., Wolf, Anitra C., Hamacher, Nels B., Snavely, Mark, Dillon, Stacey R.

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TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients von Chauvin, Joe-Marc, Pagliano, Ornella, Fourcade, Julien, Sun, Zhaojun, Wang, Hong, Sander, Cindy, Kirkwood, John M, Chen, Tseng-hui Timothy, Maurer, Mark, Korman, Alan J, Zarour, Hassane M

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244 Anti-Interleukin (IL)-21 Monoclonal Antibody Reduces Disease Severity and Inflammatory Cytokines in Murine Colitis von Lewis, Katherine E, Bilsborough, Janine, Maurer, Mark F, Bontadelli, Kristen, Waggie, Kim, Krejsa, Cecile M, Dillon, Stacey R

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IL-31 is associated with cutaneous lymphocyte antigen–positive skin homing T cells in patients with atopic dermatitis von Bilsborough, Janine, Leung, Donald Y.M., Maurer, Mark, Howell, Michael, Boguniewcz, Mark, Yao, Lena, Storey, Harold, LeCiel, Cosette, Harder, Brandon, Gross, Jane A.

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Identification of a Mammalian Angiopoietin-Related Protein Expressed Specifically in Liver von Conklin, Darrell, Gilbertson, Debra, Taft, David W., Maurer, Mark F., Whitmore, Theodore E., Smith, Deborah L., Walker, Kathleen M., Chen, Lennie H., Wattler, Sigrid, Nehls, Michael, Lewis, Kenneth B.

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Abstract LB-085: ALPN-202 combines checkpoint inhibition with conditional T cell costimulation to overcome T cell suppression by M2c macrophages and improve the durability of engin... von Maurer, Mark F., Chandrasekaran, Siddarth, Lewis, Katherine, Mudri, Sherri, Kleist, Kayla, Ahmed-Qadri, Fariha, Gudgeon, Chelsea, Levin, Steven D., Dillon, Stacey R., Swiderek, Kristine M., Peng, Stanford L.

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Abstract 1740: Engineered variant domain fusion proteins provide checkpoint inhibition and tumor antigen dependent CD28 costimulation resulting in potent anti-tumor immunity von Levin, Steven D., Maurer, Mark F., Gudgeon, Chelsea, Chandrasekaran, Siddarth, Ardourel, Daniel, Demonte, Daniel, Kuijper, Joseph, Wolfson, Martin, Garrett, Logan, Kleist, Kayla N., Mudri, Sherri, Nguyen, Hieu, Seaberg, Michelle, Wang, Rachel, Yang, Jing, Lewis, Katherine E., Dillon, Stacey R., Rixon, Mark, Peng, Stanford L.

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Abstract 4550: CD80 vIgD-Fc proteins combine checkpoint antagonism and costimulatory signaling for potent antitumor immunity von Swanson, Ryan, Maurer, Mark F., Navas, Chris L., Gudgeon, Chelsea J., Kuijper, Joseph L., Wolfson, Martin, Lewis, Katherine E., Dillon, Stacey R., Levin, Steve D., Kornacker, Michael G.

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B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell matur... von Dillon, Stacey R, Harder, Brandon, Lewis, Kenneth B, Moore, Margaret D, Liu, Hong, Bukowski, Thomas R, Hamacher, Nels B, Lantry, Megan M, Maurer, Mark, Krejsa, Cecile M, Ellsworth, Jeff L, Pederson, Susan, Elkon, Keith B, Wener, Mark H, Dall'Era, Maria, Gross, Jane A

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Survivorship, complications and patient-reported outcomes in calcar-guided short-stem THA: prospective mid-term multicenter data of the first 879 hips von Kutzner, Karl Philipp, Maurer, Steven Mark, Meinecke, Ingmar, Heers, Guido, Bosson, Dominique

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Abstract 459: Targeting TIGIT and PD-1 to increase the expansion and function of tumor antigen-specific CD8+ T cells in melanoma patients von Chauvin, Joe-Marc, Pagliano, Ornella, Fourcade, Julien, Sun, Zhaojun, Sanders, Cindy, Kirkwood, John M., Chen, Tseng-hui T., Maurer, Mark, Korman, Alan, Zarour, Hassane

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TIGIT and PD-1 impair tumor antigen-specific CD8^sup +^ T cells in melanoma patients von Chauvin, Joe-Marc, Pagliano, Ornella, Fourcade, Julien, Sun, Zhaojun, Wang, Hong, Sander, Cindy, Kirkwood, John M, Chen, Tseng-hui Timothy, Maurer, Mark, Korman, Alan J, Zarour, Hassane M

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TIGIT and PD-1 impair tumor antigen-specific CD8 super( +) T cells in melanoma patients von Chauvin, Joe-Marc, Pagliano, Ornella, Fourcade, Julien, Sun, Zhaojun, Wang, Hong, Sander, Cindy, Kirkwood, John M, Chen, Tseng-hui Timothy, Maurer, Mark, Korman, Alan J, Zarour, Hassane M

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TIGIT and PD-1 impair tumor antigen-specific [CD8.sup.+] T cells in melanoma patients von Chauvin, Joe-Marc, Pagliano, Ornella, Fourcade, Julien, Sun, Zhaojun, Wang, Hong, Sander, Cindy, Kirkwood, John M, Chen, Tseng-hui Timothy, Maurer, Mark, Korman, Alan J, Zarour, Hassane M

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