Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit von Byrn, Randal A, Jones, Steven M, Bennett, Hamilton B, Bral, Chris, Clark, Michael P, Jacobs, Marc D, Kwong, Ann D, Ledeboer, Mark W, Leeman, Joshua R, McNeil, Colleen F, Murcko, Mark A, Nezami, Azin, Perola, Emanuele, Rijnbrand, Rene, Saxena, Kumkum, Tsai, Alice W, Zhou, Yi, Charifson, Paul S

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Structural basis of TRPC4 regulation by calmodulin and pharmacological agents von Vinayagam, Deivanayagabarathy, Quentin, Dennis, Yu-Strzelczyk, Jing, Sitsel, Oleg, Merino, Felipe, Stabrin, Markus, Hofnagel, Oliver, Yu, Maolin, Ledeboer, Mark W, Nagel, Georg, Malojcic, Goran, Raunser, Stefan

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Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model von Yu, Maolin, Ledeboer, Mark W, Daniels, Matthew, Malojcic, Goran, Tibbitts, Thomas T, Coeffet-Le Gal, Marie, Pan-Zhou, Xin-Ru, Westerling-Bui, Amy, Beconi, Maria, Reilly, John F, Mundel, Peter, Harmange, Jean-Christophe

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Dual p38/JNK mitogen activated protein kinase inhibitors prevent ozone-induced airway hyperreactivity in guinea pigs von Verhein, Kirsten C, Salituro, Francesco G, Ledeboer, Mark W, Fryer, Allison D, Jacoby, David B

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Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3‑Kinase γ von Collier, Philip N., Messersmith, David, Le Tiran, Arnaud, Bandarage, Upul K., Boucher, Christina, Come, Jon, Cottrell, Kevin M., Damagnez, Veronique, Doran, John D., Griffith, James P., Khare-Pandit, Suvarna, Krueger, Elaine B., Ledeboer, Mark W., Ledford, Brian, Liao, Yusheng, Mahajan, Sudipta, Moody, Cameron S., Roday, Setu, Wang, Tiansheng, Xu, Jinwang, Aronov, Alex M.

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Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors von Boyd, Michael J, Bandarage, Upul K, Bennett, Hamilton, Byrn, Randal R, Davies, Ioana, Gu, Wenxin, Jacobs, Marc, Ledeboer, Mark W, Ledford, Brian, Leeman, Joshua R, Perola, Emanuele, Wang, Tiansheng, Bennani, Youssef, Clark, Michael P, Charifson, Paul S

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Novel 2‑Substituted 7‑Azaindole and 7‑Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza von Bandarage, Upul K., Clark, Michael P., Perola, Emanuele, Gao, Huai, Jacobs, Marc D., Tsai, Alice, Gillespie, Jeffery, Kennedy, Joseph M., Maltais, François, Ledeboer, Mark W., Davies, Ioana, Gu, Wenxin, Byrn, Randal A., Nti Addae, Kwame, Bennett, Hamilton, Leeman, Joshua R., Jones, Steven M., O’Brien, Colleen, Memmott, Christine, Bennani, Youssef, Charifson, Paul S.

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Transplanted organoids empower human preclinical assessment of drug candidate for the clinic von Westerling-Bui, Amy D., Fast, Eva Maria, Soare, Thomas W., Venkatachalan, Srinivasan, DeRan, Michael, Fanelli, Alyssa B., Kyrychenko, Sergii, Hoang, Hien, Corriea, Grinal M., Zhang, Wei, Yu, Maolin, Daniels, Matthew, Malojcic, Goran, Pan-Zhou, Xin-Ru, Ledeboer, Mark W., Harmange, Jean-Christophe, Emani, Maheswarareddy, Tibbitts, Thomas T., Reilly, John F., Mundel, Peter

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Discovery of Novel, Orally Bioavailable β‑Amino Acid Azaindole Inhibitors of Influenza PB2 von Farmer, Luc J., Clark, Michael P., Boyd, Michael J., Perola, Emanuele, Jones, Steven M., Tsai, Alice, Jacobs, Marc D., Bandarage, Upul K., Ledeboer, Mark W., Wang, Tiansheng, Deng, Hongbo, Ledford, Brian, Gu, Wenxin, Duffy, John P., Bethiel, Randy S., Shannon, Dean, Byrn, Randal A., Leeman, Joshua R., Rijnbrand, Rene, Bennett, Hamilton B., O’Brien, Colleen, Memmott, Christine, Nti-Addae, Kwame, Bennani, Youssef L., Charifson, Paul S.

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A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors von Wang, Tiansheng, Ledeboer, Mark W., Duffy, John P., Pierce, Albert C., Zuccola, Harmon J., Block, Eric, Shlyakter, Dina, Hogan, James K., Bennani, Youssef L.

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Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole von Wang, Tiansheng, Duffy, John P, Wang, Jian, Halas, Summer, Salituro, Francesco G, Pierce, Albert C, Zuccola, Harmon J, Black, James R, Hogan, James K, Jepson, Scott, Shlyakter, Dina, Mahajan, Sudipta, Gu, Yong, Hoock, Thomas, Wood, Mark, Furey, Brinley F, Frantz, J. Daniel, Dauffenbach, Lisa M, Germann, Ursula A, Fan, Bin, Namchuk, Mark, Bennani, Youssef L, Ledeboer, Mark W

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2-Aminopyrazolo[1,5- a]pyrimidines as potent and selective inhibitors of JAK2 von Ledeboer, Mark W., Pierce, Albert C., Duffy, John P., Gao, Huai, Messersmith, David, Salituro, Francesco G., Nanthakumar, Suganthini, Come, Jon, Zuccola, Harmon J., Swenson, Lora, Shlyakter, Dina, Mahajan, Sudipta, Hoock, Thomas, Fan, Bin, Tsai, Wan-Jung, Kolaczkowski, Elaine, Carrier, Scott, Hogan, James K., Zessis, Richard, Pazhanisamy, S., Bennani, Youssef L.

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Asymmetric Reduction. A Convenient Method for the Reduction of Alkynyl Ketones von Parker, Kathlyn A, Ledeboer, Mark W

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Discovery and Optimization of Highly Selective Inhibitors of CDK5 von Daniels, Matthew H, Malojcic, Goran, Clugston, Susan L, Williams, Brett, Coeffet-Le Gal, Marie, Pan-Zhou, Xin-Ru, Venkatachalan, Srinivasan, Harmange, Jean-Christophe, Ledeboer, Mark

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Total Synthesis and Comparative Evaluation of Luzopeptin A−C and Quinoxapeptin A−C von Boger, Dale L, Ledeboer, Mark W, Kume, Masaharu, Searcey, Mark, Jin, Qing

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Total Synthesis of Quinoxapeptin A-C: Establishment of Absolute Stereochemistry von Boger, Dale L., Ledeboer, Mark W., Kume, Masaharu, Jin, Qing

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Total Synthesis of Luzopeptins A−C von Boger, Dale L, Ledeboer, Mark W, Kume, Masaharu

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SO038A TRANSLATIONAL KIDNEY ORGANOID SYSTEM BOLSTERS HUMAN RELEVANCE OF CLINICAL DEVELOPMENT CANDIDATE von Westerling-Bui, Amy, Soare, Thomas, Venkatachalan, Srinivasan, DeRan, Michael, Fast, Eva, Fanelli, Alyssa, Kyrychenko, Sergii, Hoang, Hien, Corriea, Grinal, Zhang, Wei, Yu, Maolin, Malojcic, Goran, Pan-Zhou, Xin-Ru, Ledeboer, Mark, Harmange, Jean-Christophe, Emani, Maheswarareddy, Tibbitts, Thomas T, Reilly, John, Mundel, Peter

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Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2 von Clark, Michael P, Ledeboer, Mark W, Davies, Ioana, Byrn, Randal A, Jones, Steven M, Perola, Emanuele, Tsai, Alice, Jacobs, Marc, Nti-Addae, Kwame, Bandarage, Upul K, Boyd, Michael J, Bethiel, Randy S, Court, John J, Deng, Hongbo, Duffy, John P, Dorsch, Warren A, Farmer, Luc J, Gao, Huai, Gu, Wenxin, Jackson, Katrina, Jacobs, Dylan H, Kennedy, Joseph M, Ledford, Brian, Liang, Jianglin, Maltais, François, Murcko, Mark, Wang, Tiansheng, Wannamaker, M. Woods, Bennett, Hamilton B, Leeman, Joshua R, McNeil, Colleen, Taylor, William P, Memmott, Christine, Jiang, Min, Rijnbrand, Rene, Bral, Christopher, Germann, Ursula, Nezami, Azin, Zhang, Yuegang, Salituro, Francesco G, Bennani, Youssef L, Charifson, Paul S

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Corrigendum to “Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 i... von Boyd, Michael J., Bandarage, Upul K., Bennett, Hamilton, Byrn, Randal R., Davies, Ioana, Gu, Wenxin, Jacobs, Marc, Ledeboer, Mark W., Ledford, Brian, Leeman, Joshua R., Perola, Emanuele, Wang, Tiansheng, Bennani, Youssef, Clark, Michael P., Charifson, Paul S.

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