Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors von Jiao, XianYun, Kopecky, David J., Liu, JinSong, Liu, JinQian, Jaen, Juan C., Cardozo, Mario G., Sharma, Rajiv, Walker, Nigel, Wesche, Holger, Li, Shyun, Farrelly, Ellyn, Xiao, Shou-Hua, Wang, Zhulun, Kayser, Frank

Volltext

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2 von Poncet-Montange, Guillaume, Zhan, Yanai, Bardenhagen, Jennifer P, Petrocchi, Alessia, Leo, Elisabetta, Shi, Xi, Lee, 4th, Gilbert R, Leonard, Paul G, Geck Do, Mary K, Cardozo, Mario G, Andersen, Jannik N, Palmer, Wylie S, Jones, Philip, Ladbury, John E

Volltext

Discovery of potent and selective PKC-θ inhibitors von Cywin, Charles L., Dahmann, Georg, Prokopowicz, Anthony S., Young, Erick R.R., Magolda, Ronald L., Cardozo, Mario G., Cogan, Derek A., DiSalvo, Darren, Ginn, John D., Kashem, Mohammed A., Wolak, John P., Homon, Carol A., Farrell, Thomas M., Grbic, Heather, Hu, Hanbo, Kaplita, Paul V., Liu, Lisa H., Spero, Denice M., Jeanfavre, Deborah D., O’Shea, Kathy M., White, Della M., Woska, Joseph R., Brown, Maryanne L.

Volltext

Discovery of 2-Phenylamino-imidazo[4,5-h]isoquinolin-9-ones:  A New Class of Inhibitors of Lck Kinase von Snow, Roger J, Cardozo, Mario G, Morwick, Tina M, Busacca, Carl A, Dong, Yong, Eckner, Robert J, Jacober, Stephen, Jakes, Scott, Kapadia, Suresh, Lukas, Susan, Panzenbeck, Maret, Peet, Gregory W, Peterson, Jeffrey D, Prokopowicz, Anthony S, Sellati, Rosemarie, Tolbert, Robert M, Tschantz, Matt A, Moss, Neil

Volltext

Optimization of 2-Phenylaminoimidazo[4,5-h]isoquinolin-9-ones:  Orally Active Inhibitors of lck Kinase von Goldberg, Daniel R, Butz, Tanja, Cardozo, Mario G, Eckner, Robert J, Hammach, Abdelhakim, Huang, Jessica, Jakes, Scott, Kapadia, Suresh, Kashem, Mohammed, Lukas, Susan, Morwick, Tina M, Panzenbeck, Maret, Patel, Usha, Pav, Susan, Peet, Gregory W, Peterson, Jeffrey D, Prokopowicz, Anthony S, Snow, Roger J, Sellati, Rosemarie, Takahashi, Hidenori, Tan, Jonathan, Tschantz, Matt A, Wang, Xiao-Jun, Wang, Yong, Wolak, John, Xiong, Pla, Moss, Neil

Volltext

Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors von Kopecky, David J, Hao, Xiaolin, Chen, Yi, Fu, Jiasheng, Jiao, XianYun, Jaen, Juan C, Cardozo, Mario G, Liu, Jinsong, Wang, Zhulun, Walker, Nigel P C, Wesche, Holger, Li, Shyun, Farrelly, Ellyn, Xiao, Shou-Hua, Kayser, Frank

Volltext

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2A von Poncet-Montange, Guillaume, Zhan, Yanai, Bardenhagen, Jennifer P., Petrocchi, Alessia, Leo, Elisabetta, Shi, Xi, Lee, Gilbert R., Leonard, Paul G., Geck Do, Mary K., Cardozo, Mario G., Andersen, Jannik N., Palmer, Wylie S., Jones, Philip, Ladbury, John E.

Volltext

Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase von Cardozo, Mario G, Kawai, Takatoshi, Iimura, Youichi, Sugimoto, Hachiro, Yamanishi, Yoshiharu, Hopfinger, A. J

Volltext

A Novel Frequency Distribution Selection Method for Efficient Plate Layout of a Diverse Combinatorial Library von Graham, Edward T, Jacober, Stephen P, Cardozo, Mario G

Volltext

A model for the dynemicin-A cleavage of DNA using molecular dynamics simulation von Cardozo, Mario G., Hopfinger, A. J.

Volltext

Quantitative structure-activity relationship. QSAR, analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcho... von Cardozo, Mario G, Iimura, Youichi, Sugimoto, Hachiro, Yamanishi, Yoshiharu, Hopfinger, A. J

Volltext

Identification and optimization of N super(3),N super(6)-diaryl-1H- pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors von Kopecky, David J, Hao, Xiaolin, Chen, Yi, Fu, Jiasheng, Jiao, XianYun, Jaen, Juan C, Cardozo, Mario G, Liu, Jinsong, Wang, Zhulun, Walker, Nigel PC, Wesche, Holger, Li, Shyun, Farrelly, Ellyn, Xiao, Shou-Hua, Kayser, Frank

Volltext

Quantitative structure-activity relationship. QSAR, analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcho... von Cardozo, Mario G, Iimura, Youichi, Sugimoto, Hachiro, Yamanishi, Yoshiharu, Hopfinger, A. J

Volltext

Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. [Erratum to document cited in CA116(11):98893e] von Cardozo, Mario G, Kawai, Takatoshi, Iimura, Youichi, Sugimoto, Hachiro, Yamanishi, Yoshiharu, Hopfinger, A. J

Volltext

LRRK2 INHIBITORS von SWEENEY, Zachary K, GUO, Zuojun, MOREAU, Robert J, TULLY, David C, CARDOZO, Mario G

Volltext bestellen

LRRK2 INHIBITORS von GUO, Zuojun, MOREAU, Robert J, TULLY, David C, CARDOZO, Mario G, RAJAPAKSA, Naomi S, RAO, Meera

Volltext bestellen

Identification and optimization of N 3, N 6-diaryl-1 H-pyrazolo[3,4- d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors von Kopecky, David J., Hao, Xiaolin, Chen, Yi, Fu, Jiasheng, Jiao, XianYun, Jaen, Juan C., Cardozo, Mario G., Liu, Jinsong, Wang, Zhulun, Walker, Nigel P.C., Wesche, Holger, Li, Shyun, Farrelly, Ellyn, Xiao, Shou-Hua, Kayser, Frank

Volltext

LRRK2 INHIBITORS von SWEENEY, Zachary K, GUO, Zuojun, MOREAU, Robert J, TULLY, David C, CARDOZO, Mario G

Volltext bestellen

LRRK2 INHIBITORS von GUO, Zuojun, MOREAU, Robert J, TULLY, David C, CARDOZO, Mario G, RAJAPAKSA, Naomi S, RAO, Meera

Volltext bestellen

Identification and optimization of N3,N6-diaryl-lH-pyrazolo[3,4-d] pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors von KOPECKY, David J, XIAOLIN HAO, WESCHE, Holger, LI, Shyun, FARRELLY, Ellyn, XIAO, Shou-Hua, KAYSER, Frank, YI CHEN, JIASHENG FU, XIANYUN JIAO, JAEN, Juan C, CARDOZO, Mario G, JINSONG LIU, ZHULUN WANG, WALKER, Nigel P. C

Volltext