Target-induced clustering activates Trim-Away of pathogens and proteins von Zeng, Jingwei, Santos, Ana Filipa, Mukadam, Aamir S., Osswald, Mariana, Jacques, David A., Dickson, Claire F., McLaughlin, Stephen H., Johnson, Christopher M., Kiss, Leo, Luptak, Jakub, Renner, Nadine, Vaysburd, Marina, McEwan, William A., Morais-de-Sá, Eurico, Clift, Dean, James, Leo C.

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Cholesterol determines the cytosolic entry and seeded aggregation of tau von Tuck, Benjamin J., Miller, Lauren V.C., Katsinelos, Taxiarchis, Smith, Annabel E., Wilson, Emma L., Keeling, Sophie, Cheng, Shi, Vaysburd, Marina J., Knox, Claire, Tredgett, Lucy, Metzakopian, Emmanouil, James, Leo C., McEwan, William A.

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Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21 von Dickson, Claire, Fletcher, Adam J, Vaysburd, Marina, Yang, Ji-Chun, Mallery, Donna L, Zeng, Jingwei, Johnson, Christopher M, McLaughlin, Stephen H, Skehel, Mark, Maslen, Sarah, Cruickshank, James, Huguenin-Dezot, Nicolas, Chin, Jason W, Neuhaus, David, James, Leo C

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Intracellular neutralisation of rotavirus by VP6-specific IgG von Caddy, Sarah L, Vaysburd, Marina, Wing, Mark, Foss, Stian, Andersen, Jan Terje, O'Connell, Kevin, Mayes, Keith, Higginson, Katie, Iturriza-Gómara, Miren, Desselberger, Ulrich, James, Leo C

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Aggregate-selective removal of pathological tau by clustering-activated degraders von Benn, Jonathan, Cheng, Shi, Keeling, Sophie, Smith, Annabel E, Vaysburd, Marina J, Böken, Dorothea, Miller, Lauren V C, Katsinelos, Taxiarchis, Franco, Catarina, Dupré, Elian, Danis, Clément, Landrieu, Isabelle, Buée, Luc, Klenerman, David, James, Leo C, McEwan, William A

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Aggregate-selective removal of pathological tau via clustering-activated degraders von Benn, Jonathan, Cheng, Shi, Keeling, Sophie, Smith, Annabel, Vaysburd, Marina, Böken, Dorothea, Miller, Lauren, Katsinelos, Taxiarchis, Franco, Catarina, Dupré, Elian, Danis, Clément, Landrieu, Isabelle, Buée, Luc, Klenerman, David, James, Leo, Mcewan, William

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TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus von Watkinson, Ruth E, McEwan, William A, Tam, Jerry C H, Vaysburd, Marina, James, Leo C

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Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication von Mallery, Donna L., Faysal, K.M. Rifat, Kleinpeter, Alex, Wilson, Miranda S.C., Vaysburd, Marina, Fletcher, Adam J., Novikova, Mariia, Böcking, Till, Freed, Eric O., Saiardi, Adolfo, James, Leo C.

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TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination von Bottermann, Maria, Foss, Stian, van Tienen, Laurens M., Vaysburd, Marina, Cruickshank, James, O’Connell, Kevin, Clark, Jessica, Mayes, Keith, Higginson, Katie, Hirst, Jack C., McAdam, Martin B., Slodkowicz, Greg, Hutchinson, Edward, Kozik, Patrycja, Andersen, Jan Terje, James, Leo C.

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Intracellular antibody receptor TRIM21 prevents fatal viral infection von Vaysburd, Marina, Watkinson, Ruth E., Cooper, Helen, Reed, Martin, O'Connell, Kevin, Smith, Jackie, Cruickshanks, James, James, Leo C.

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Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2 von Gaynor, Katherine U., Vaysburd, Marina, Harman, Maximilian A. J., Albecka, Anna, Jeffrey, Phillip, Beswick, Paul, Papa, Guido, Chen, Liuhong, Mallery, Donna, McGuinness, Brian, Van Rietschoten, Katerine, Stanway, Steven, Brear, Paul, Lulla, Aleksei, Ciazynska, Katarzyna, Chang, Veronica T., Sharp, Jo, Neary, Megan, Box, Helen, Herriott, Jo, Kijak, Edyta, Tatham, Lee, Bentley, Eleanor G., Sharma, Parul, Kirby, Adam, Han, Ximeng, Stewart, James P., Owen, Andrew, Briggs, John A. G., Hyvönen, Marko, Skynner, Michael J., James, Leo C.

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Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue von Miller, Lauren V C, Mukadam, Aamir S, Durrant, Claire S, Vaysburd, Marina J, Katsinelos, Taxiarchis, Tuck, Benjamin J, Sanford, Sophie, Sheppard, Olivia, Knox, Claire, Cheng, Shi, James, Leo C, Coleman, Michael P, McEwan, William A

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IP6‐stabilised HIV capsids evade cGAS/STING‐mediated host immune sensing von Papa, Guido, Albecka, Anna, Mallery, Donna, Vaysburd, Marina, Renner, Nadine, James, Leo C

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Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation von McEwan, William A., Falcon, Benjamin, Vaysburd, Marina, Clift, Dean, Oblak, Adrian L., Ghetti, Bernardino, Goedert, Michel, James, Leo C.

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Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity von Caddy, Sarah L, Vaysburd, Marina, Papa, Guido, Wing, Mark, O’Connell, Kevin, Stoycheva, Diana, Foss, Stian, Terje Andersen, Jan, Oxenius, Annette, James, Leo C

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Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling von Fletcher, Adam J., Vaysburd, Marina, Maslen, Sarah, Zeng, Jingwei, Skehel, J. Mark, Towers, Greg J., James, Leo C.

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Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection von Labzin, Larisa I, Bottermann, Maria, Rodriguez‐Silvestre, Pablo, Foss, Stian, Andersen, Jan Terje, Vaysburd, Marina, Clift, Dean, James, Leo C

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A functional assay for serum detection of antibodies against SARS‐CoV‐2 nucleoprotein von Albecka, Anna, Clift, Dean, Vaysburd, Marina, Rhinesmith, Tyler, Caddy, Sarah L, Favara, David M, Baxendale, Helen E, James, Leo C

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Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice von Salzer, Ralf, Clark, Jordan J., Vaysburd, Marina, Chang, Veronica T., Albecka, Anna, Kiss, Leo, Sharma, Parul, Gonzalez Llamazares, Andres, Kipar, Anja, Hiscox, Julian A., Owen, Andrew, Aricescu, A. Radu, Stewart, James P., James, Leo C., Löwe, Jan

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Complement C4 Prevents Viral Infection through Capsid Inactivation von Bottermann, Maria, Foss, Stian, Caddy, Sarah L., Clift, Dean, van Tienen, Laurens M., Vaysburd, Marina, Cruickshank, James, O’Connell, Kevin, Clark, Jessica, Mayes, Keith, Higginson, Katie, Lode, Heidrun E., McAdam, Martin B., Sandlie, Inger, Andersen, Jan Terje, James, Leo C.

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