Exploitation of Castration-Resistant Prostate Cancer Transcription Factor Dependencies by the Novel BET Inhibitor ABBV-075 von Faivre, Emily J, Wilcox, Denise, Lin, Xiaoyu, Hessler, Paul, Torrent, Maricel, He, Wei, Uziel, Tamar, Albert, Daniel H, McDaniel, Keith, Kati, Warren, Shen, Yu

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PINNED: identifying characteristics of druggable human proteins using an interpretable neural network von Cunningham, Michael, Pins, Danielle, Dezső, Zoltán, Torrent, Maricel, Vasanthakumar, Aparna, Pandey, Abhishek

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Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315 von Jakob, Clarissa G, Upadhyay, Anup K, Donner, Pamela L, Nicholl, Emily, Addo, Sadiya N, Qiu, Wei, Ling, Christopher, Gopalakrishnan, Sujatha M, Torrent, Maricel, Cepa, Steven P, Shanley, Jason, Shoemaker, Alexander R, Sun, Chaohong C, Vasudevan, Anil, Woller, Kevin R, Shotwell, J. Brad, Shaw, Bailin, Bian, Zhiguo, Hutti, Jessica E

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Theoretical Studies of Some Transition-Metal-Mediated Reactions of Industrial and Synthetic Importance von Torrent, Maricel, Solà, Miquel, Frenking, Gernot

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SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding von Curtin, Michael L., Pliushchev, Marina A., Li, Huan-Qiu, Torrent, Maricel, Dietrich, Justin D., Jakob, Clarissa G., Zhu, Haizhong, Zhao, Hongyu, Wang, Ying, Ji, Zhiqin, Clark, Richard F., Sarris, Kathy A., Selvaraju, Sujatha, Shaw, Bailin, Algire, Mikkel A., He, Yupeng, Richardson, Paul L., Sweis, Ramzi F., Sun, Chaohong, Chiang, Gary G., Michaelides, Michael R.

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WD40 repeat domain proteins: a novel target class? von Schapira, Matthieu, Tyers, Mike, Torrent, Maricel, Arrowsmith, Cheryl H.

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Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP von Cox, Christopher D., Breslin, Michael J., Mariano, Brenda J., Coleman, Paul J., Buser, Carolyn A., Walsh, Eileen S., Hamilton, Kelly, Huber, Hans E., Kohl, Nancy E., Torrent, Maricel, Yan, Youwei, Kuo, Laurence C., Hartman, George D.

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Effects of the Protein Environment on the Structure and Energetics of Active Sites of Metalloenzymes. ONIOM Study of Methane Monooxygenase and Ribonucleotide Reductase von Torrent, Maricel, Vreven, Thom, Musaev, Djamaladdin G, Morokuma, Keiji, Farkas, Ödön, Schlegel, H. Bernhard

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Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP von Rickert, Keith W., Schaber, Michael, Torrent, Maricel, Neilson, Lou Anne, Tasber, Edward S., Garbaccio, Robert, Coleman, Paul J., Harvey, Diane, Zhang, Yun, Yang, Yi, Marshall, Gary, Lee, Ling, Walsh, Eileen S., Hamilton, Kelly, Buser, Carolyn A.

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Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours von Lasko, Loren M., Jakob, Clarissa G., Edalji, Rohinton P., Qiu, Wei, Montgomery, Debra, Digiammarino, Enrico L., Hansen, T. Matt, Risi, Roberto M., Frey, Robin, Manaves, Vlasios, Shaw, Bailin, Algire, Mikkel, Hessler, Paul, Lam, Lloyd T., Uziel, Tamar, Faivre, Emily, Ferguson, Debra, Buchanan, Fritz G., Martin, Ruth L., Torrent, Maricel, Chiang, Gary G., Karukurichi, Kannan, Langston, J. William, Weinert, Brian T., Choudhary, Chunaram, de Vries, Peter, Kluge, Arthur F., Patane, Michael A., Van Drie, John H., Wang, Ce, McElligott, David, Kesicki, Ed, Marmorstein, Ronen, Sun, Chaohong, Cole, Philip A., Rosenberg, Saul H., Michaelides, Michael R., Lai, Albert, Bromberg, Kenneth D.

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Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer von Faivre, Emily J., McDaniel, Keith F., Albert, Daniel H., Mantena, Srinivasa R., Plotnik, Joshua P., Wilcox, Denise, Zhang, Lu, Bui, Mai H., Sheppard, George S., Wang, Le, Sehgal, Vasudha, Lin, Xiaoyu, Huang, Xiaoli, Lu, Xin, Uziel, Tamar, Hessler, Paul, Lam, Lloyd T., Bellin, Richard J., Mehta, Gaurav, Fidanze, Steve, Pratt, John K., Liu, Dachun, Hasvold, Lisa A., Sun, Chaohong, Panchal, Sanjay C., Nicolette, John J., Fossey, Stacey L., Park, Chang H., Longenecker, Kenton, Bigelow, Lance, Torrent, Maricel, Rosenberg, Saul H., Kati, Warren M., Shen, Yu

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Computational studies of reaction mechanisms of methane monooxygenase and ribonucleotide reductase von Torrent, Maricel, Musaev, Djamaladdin G., Basch, Harold, Morokuma, Keiji

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Discovery of N‑Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo‑1H‑pyrrolo[2,3‑c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain I... von Sheppard, George S, Wang, Le, Fidanze, Steven D, Hasvold, Lisa A, Liu, Dachun, Pratt, John K, Park, Chang H, Longenecker, Kenton, Qiu, Wei, Torrent, Maricel, Kovar, Peter J, Bui, Mai, Faivre, Emily, Huang, Xiaoli, Lin, Xiaoyu, Wilcox, Denise, Zhang, Lu, Shen, Yu, Albert, Daniel H, Magoc, Terrance J, Rajaraman, Ganesh, Kati, Warren M, McDaniel, Keith F

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Discovery of N -Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1 H -pyrrolo[2,3- c ]pyridine-2-carboxamide (ABBV-744), a BET Bromodom... von Sheppard, George S, Wang, Le, Fidanze, Steven D, Hasvold, Lisa A, Liu, Dachun, Pratt, John K, Park, Chang H, Longenecker, Kenton, Qiu, Wei, Torrent, Maricel, Kovar, Peter J, Bui, Mai, Faivre, Emily, Huang, Xiaoli, Lin, Xiaoyu, Wilcox, Denise, Zhang, Lu, Shen, Yu, Albert, Daniel H, Magoc, Terrance J, Rajaraman, Ganesh, Kati, Warren M, McDaniel, Keith F

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The Flexibility of Carboxylate Ligands in Methane Monooxygenase and Ribonucleotide Reductase:  A Density Functional Study von Torrent, Maricel, Musaev, Djamaladdin G, Morokuma, Keiji

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The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex von He, Yupeng, Selvaraju, Sujatha, Curtin, Michael L, Jakob, Clarissa G, Zhu, Haizhong, Comess, Kenneth M, Shaw, Bailin, The, Juliana, Lima-Fernandes, Evelyne, Szewczyk, Magdalena M, Cheng, Dong, Klinge, Kelly L, Li, Huan-Qiu, Pliushchev, Marina, Algire, Mikkel A, Maag, David, Guo, Jun, Dietrich, Justin, Panchal, Sanjay C, Petros, Andrew M, Sweis, Ramzi F, Torrent, Maricel, Bigelow, Lance J, Senisterra, Guillermo, Li, Fengling, Kennedy, Steven, Wu, Qin, Osterling, Donald J, Lindley, David J, Gao, Wenqing, Galasinski, Scott, Barsyte-Lovejoy, Dalia, Vedadi, Masoud, Buchanan, Fritz G, Arrowsmith, Cheryl H, Chiang, Gary G, Sun, Chaohong, Pappano, William N

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WD-repeat domain proteins: a novel target class? von Schapira, Matthieu, Tyers, Mike, Torrent, Maricel, Arrowsmith, Cheryl H.

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Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors von Geneste, Hervé, Drescher, Karla, Jakob, Clarissa, Laplanche, Loïc, Ochse, Michael, Torrent, Maricel

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Density Functional Study of the [2+2]- and [2+3]-Cycloaddition Mechanisms for the Osmium-Catalyzed Dihydroxylation of Olefins von Torrent, Maricel, Deng, Liqun, Duran, Miquel, Sola, Miquel, Ziegler, Tom

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The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity von Bromberg, Kenneth D, Mitchell, Taylor R H, Upadhyay, Anup K, Jakob, Clarissa G, Jhala, Manisha A, Comess, Kenneth M, Lasko, Loren M, Li, Conglei, Tuzon, Creighton T, Dai, Yujia, Li, Fengling, Eram, Mohammad S, Nuber, Alexander, Soni, Niru B, Manaves, Vlasios, Algire, Mikkel A, Sweis, Ramzi F, Torrent, Maricel, Schotta, Gunnar, Sun, Chaohong, Michaelides, Michael R, Shoemaker, Alex R, Arrowsmith, Cheryl H, Brown, Peter J, Santhakumar, Vijayaratnam, Martin, Alberto, Rice, Judd C, Chiang, Gary G, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Pappano, William N

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