Loss of COP9 signalosome genes at 2q37 is associated with IMiD resistance in multiple myeloma von Gooding, Sarah, Ansari-Pour, Naser, Kazeroun, Mohammad, Karagoz, Kubra, Polonskaia, Ann, Salazar, Mirian, Fitzsimons, Evie, Sirinukunwattana, Korsuk, Chavda, Selina, Ortiz Estevez, Maria, Towfic, Fadi, Flynt, Erin, Pierceall, William, Royston, Daniel, Yong, Kwee, Ramasamy, Karthik, Vyas, Paresh, Thakurta, Anjan

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Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma von Gooding, Sarah, Ansari-Pour, Naser, Towfic, Fadi, Ortiz Estévez, María, Chamberlain, Philip P., Tsai, Kao-Tai, Flynt, Erin, Hirst, Marissa, Rozelle, Dan, Dhiman, Paula, Neri, Paola, Ramasamy, Karthik, Bahlis, Nizar, Vyas, Paresh, Thakurta, Anjan

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Getting DNA copy numbers without control samples von Ortiz-Estevez, Maria, Aramburu, Ander, Rubio, Angel

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Multiple Myeloma Patient Tumors With High Levels of Cereblon Exon-10 Deletion Splice Variant Upregulate Clinically Targetable Pro-Inflammatory Cytokine Pathways von Karagoz, Kubra, Stokes, Matthew, Ortiz-Estévez, María, Towfic, Fadi, Flynt, Erin, Gooding, Sarah, Pierceall, William, Thakurta, Anjan

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Mezigdomide Reverses T-Cell Exhaustion through Degradation of Aiolos/Ikaros and Reinvigoration of Cytokine Production Pathways von Chiu, Hsiling, Zhao, Junfei, Ortiz Estevez, Maria, Hagner, Patrick R, Gandhi, Anita K.

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Integrative multi-omics identifies high risk multiple myeloma subgroup associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways von Ortiz-Estévez, María, Towfic, Fadi, Flynt, Erin, Stong, Nicholas, Jang, In Sock, Wang, Kai, Trotter, Matthew W B, Thakurta, Anjan

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Comparison of RNA-seq and microarray platforms for splice event detection using a cross-platform algorithm von Romero, Juan P, Ortiz-Estévez, María, Muniategui, Ander, Carrancio, Soraya, de Miguel, Fernando J, Carazo, Fernando, Montuenga, Luis M, Loos, Remco, Pío, Rubén, Trotter, Matthew W B, Rubio, Angel

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The location of the t(4;14) translocation breakpoint within the NSD2 gene identifies a subset of patients with high-risk NDMM von Stong, Nicholas, Ortiz-Estévez, María, Towfic, Fadi, Samur, Mehmet, Agarwal, Amit, Corre, Jill, Flynt, Erin, Munshi, Nikhil, Avet-Loiseau, Hervé, Thakurta, Anjan

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Tumor-intrinsic features associated with progression-free survival (PFS) in patients (pts) with relapsed and refractory multiple myeloma (RRMM) treated with idecabtagene vicleucel... von Stong, Nicholas, Thompson, Ethan, Xu, Amy, Rytlewski, Julie, Amzallag, Arnaud, Campbell, Timothy Brandon, Jagannath, Sundar, Munshi, Nikhil C., Piasecki, Julia, Basudhar, Debashree, Ortiz Estevez, Maria, Kaiser, Shari, Flynt, Erin, Martin, Nathan

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Super-Enhancer Driven Regulation of CKS1B in Multiple Myeloma: Implications in Mediating Response to BET Inhibitor and Celmod Agent Combination von Ahsan, Aarif, Polonskaia, Ann, Hsu, Chih-Chao, Bjorklund, Chad C, Ortiz Estevez, Maria, Towfic, Fadi, Bahlis, Nizar J., Pourdehnad, Michael, Flynt, Erin, Thakurta, Anjan

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Loss of COP9 Signalosome Gene-Containing 2q Region Is Associated with Lenalidomide and Pomalidomide Resistance in Myeloma Patients von Gooding, Sarah, Ansari-Pour, Naser, Kazeroun, Mohammad H, Karagoz, Kubra, Angulo Salazar, Mirian, Fitzsimons, Evelyn, Ortiz Estevez, Maria, Towfic, Fadi, Flynt, Erin, Pierceall, William E., Yong, Kwee, Vyas, Paresh, Thakurta, Anjan

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ACNE: a summarization method to estimate allele-specific copy numbers for Affymetrix SNP arrays von Ortiz-Estevez, Maria, Bengtsson, Henrik, Rubio, Angel

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Biological Features of a High-Risk Transcriptional Molecular Subtype in Diffuse Large B-Cell Lymphoma von Stokes, Matthew E, Wenzl, Kerstin, Huang, C. Chris, Ortiz Estevez, Maria, Maurer, Matthew J., Stong, Nicholas, Hagner, Patrick, Nakayama, Yumi, Hsu, Chih-Chao, Danziger, Samuel A, Towfic, Fadi, King, Rebecca L., Parker, Joel S., Link, Brian K., Slager, Susan L., Sarangi, Vivekananda, Asmann, Yan, Novak, Joseph P., Sudhindra, Akshay, Ansell, Stephen M., Habermann, Thomas M., Nowakowski, Grzegorz S., Cerhan, James R., Novak, Anne J., Gandhi, Anita K.

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Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma von Ansari-Pour, Naser, Samur, Mehmet, Flynt, Erin, Gooding, Sarah, Towfic, Fadi, Stong, Nicholas, Estevez, Maria Ortiz, Mavrommatis, Konstantinos, Walker, Brian, Morgan, Gareth, Munshi, Nikhil, Avet-Loiseau, Herve, Thakurta, Anjan

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P-010 Tumor-intrinsic features associated with progression-free survival (PFS) in patients (pts) with relapsed and refractory multiple myeloma (RRMM) treated with idecabtagene vicl... von Stong, Nicholas, Thompson, Ethan, Xu, Amy, Rytlewski, Julie, Amzallag, Arnaud, Campbell, Timothy, Jagannath, Sundar, Munshi, Nikhil, Piasecki, Julia, Basudhar, Debashree, Ortiz-Estevez, Maria, Kaiser, Shari, Martin, Nathan, Flynt, Erin

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P-264 Mezigdomide (MEZI) Reverses T-cell Exhaustion (Tex) Through Degradation of Aiolos/Ikaros and Reinvigoration of Cytokine Production Pathways von Chiu, Hsiling, Zhao, Junfei, Estevez, Maria Ortiz, Hagner, Patrick, Gandhi, Anita K., Martin, Nathan

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CalMaTe: a method and software to improve allele-specific copy number of SNP arrays for downstream segmentation von ORTIZ-ESTEVEZ, Maria, ARAMBURU, Ander, BENGTSSON, Henrik, NEUVIAL, Pierre, RUBIO, Angel

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Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL von Hagner, Patrick R, Chiu, Hsiling, Chopra, Vivek S, Colombo, Martino, Patel, Nisha, Estevez, Maria Ortiz, Waldman, Michelle F, Loos, Remco, Towfic, Fadi, Gandhi, Anita K

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Lenalidomide Exhibits Activity in Mantle Cell Lymphoma through Increased NK Cell Mediated Cytotoxicity von Hagner, Patrick, Chiu, Hsiling, Ortiz-Estevez, Maria, Biyukov, Tsvetan, Brachman, Carrie, Trneny, Marek, Arcaini, Luca, Morschhauser, Franck, Thyss, Antoine, Stilgenbauer, Stephan, Milpied, Noel, Marks, Reinhard, Musto, Pellegrino, Martinelli, Giovanni, Heise, Carla, Daniel, Thomas, Chopra, Rajesh, Carmichael, James, Trotter, Matthew, Gandhi, Anita K., Thakurta, Anjan

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Multiple Cereblon genetic changes associate with acquired resistance to Lenalidomide or Pomalidomide in Multiple Myeloma von Gooding, Sarah, Ansari-Pour, Naser, Towfic, Fadi, Ortiz Estevez, Maria, Chamberlain, Philip P, Tsai, Kao-Tai, Flynt, Erin, Hirst, Marissa, Rozelle, Dan, Dhiman, Paula, Neri, Paola, Ramasamy, Karthik, Bahlis, Nizar J, Vyas, Paresh, Thakurta, Anjan

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