Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq von Wienert, Beeke, Wyman, Stacia K., Richardson, Christopher D., Yeh, Charles D., Akcakaya, Pinar, Porritt, Michelle J., Morlock, Michaela, Vu, Jonathan T., Kazane, Katelynn R., Watry, Hannah L., Judge, Luke M., Conklin, Bruce R., Maresca, Marcello, Corn, Jacob E.

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Obligate ligation-gated recombination (ObLiGaRe): custom-designed nuclease-mediated targeted integration through nonhomologous end joining von Maresca, Marcello, Lin, Victor Guosheng, Guo, Ning, Yang, Yi

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Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements von Fabbiano, Salvatore, Suárez-Zamorano, Nicolas, Chevalier, Claire, Lazarević, Vladimir, Kieser, Silas, Rigo, Dorothée, Leo, Stefano, Veyrat-Durebex, Christelle, Gaïa, Nadia, Maresca, Marcello, Merkler, Doron, Gomez de Agüero, Mercedes, Macpherson, Andrew, Schrenzel, Jacques, Trajkovski, Mirko

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Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing von Peterka, Martin, Akrap, Nina, Li, Songyuan, Wimberger, Sandra, Hsieh, Pei-Pei, Degtev, Dmitrii, Bestas, Burcu, Barr, Jack, van de Plassche, Stijn, Mendoza-Garcia, Patricia, Šviković, Saša, Sienski, Grzegorz, Firth, Mike, Maresca, Marcello

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Improving Precise CRISPR Genome Editing by Small Molecules: Is there a Magic Potion? von Bischoff, Nadja, Wimberger, Sandra, Maresca, Marcello, Brakebusch, Cord

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Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway von Fan, Jianjia, Zhao, Rui Qi, Parro, Cameron, Zhao, Wenchen, Chou, Hsien-Ya, Robert, Jerome, Deeb, Tarek Z., Raynoschek, Carina, Barichievy, Samantha, Engkvist, Ola, Maresca, Marcello, Hicks, Ryan, Meuller, Johan, Moss, Stephen J., Brandon, Nicholas J., Wood, Michael W., Kulic, Iva, Wellington, Cheryl L.

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Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing von Wimberger, Sandra, Akrap, Nina, Firth, Mike, Brengdahl, Johan, Engberg, Susanna, Schwinn, Marie K., Slater, Michael R., Lundin, Anders, Hsieh, Pei-Pei, Li, Songyuan, Cerboni, Silvia, Sumner, Jonathan, Bestas, Burcu, Schiffthaler, Bastian, Magnusson, Björn, Di Castro, Silvio, Iyer, Preeti, Bohlooly-Y, Mohammad, Machleidt, Thomas, Rees, Steve, Engkvist, Ola, Norris, Tyrell, Cadogan, Elaine B., Forment, Josep V., Šviković, Saša, Akcakaya, Pinar, Taheri-Ghahfarokhi, Amir, Maresca, Marcello

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Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles von Degtev, Dmitrii, Bravo, Jack, Emmanouilidi, Aikaterini, Zdravković, Aleksandar, Choong, Oi Kuan, Liz Touza, Julia, Selfjord, Niklas, Weisheit, Isabel, Francescatto, Margherita, Akcakaya, Pinar, Porritt, Michelle, Maresca, Marcello, Taylor, David, Sienski, Grzegorz

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Universal toxin-based selection for precise genome engineering in human cells von Li, Songyuan, Akrap, Nina, Cerboni, Silvia, Porritt, Michelle J., Wimberger, Sandra, Lundin, Anders, Möller, Carl, Firth, Mike, Gordon, Euan, Lazovic, Bojana, Sieńska, Aleksandra, Pane, Luna Simona, Coelho, Matthew A., Ciotta, Giovanni, Pellegrini, Giovanni, Sini, Marcella, Xu, Xiufeng, Mitra, Suman, Bohlooly-Y, Mohammad, Taylor, Benjamin J. M., Sienski, Grzegorz, Maresca, Marcello

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Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery von Lundin, Anders, Porritt, Michelle J., Jaiswal, Himjyot, Seeliger, Frank, Johansson, Camilla, Bidar, Abdel Wahad, Badertscher, Lukas, Wimberger, Sandra, Davies, Emma J., Hardaker, Elizabeth, Martins, Carla P., James, Emily, Admyre, Therese, Taheri-Ghahfarokhi, Amir, Bradley, Jenna, Schantz, Anna, Alaeimahabadi, Babak, Clausen, Maryam, Xu, Xiufeng, Mayr, Lorenz M., Nitsch, Roberto, Bohlooly-Y, Mohammad, Barry, Simon T., Maresca, Marcello

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In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model von Carreras, Alba, Pane, Luna Simona, Nitsch, Roberto, Madeyski-Bengtson, Katja, Porritt, Michelle, Akcakaya, Pinar, Taheri-Ghahfarokhi, Amir, Ericson, Elke, Bjursell, Mikael, Perez-Alcazar, Marta, Seeliger, Frank, Althage, Magnus, Knöll, Ralph, Hicks, Ryan, Mayr, Lorenz M, Perkins, Rosie, Lindén, Daniel, Borén, Jan, Bohlooly-Y, Mohammad, Maresca, Marcello

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BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B von Coelho, Matthew A, Li, Songyuan, Pane, Luna Simona, Firth, Mike, Ciotta, Giovanni, Wrigley, Jonathan D, Cuomo, Maria Emanuela, Maresca, Marcello, Taylor, Benjamin J M

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Author Correction: Universal toxin-based selection for precise genome engineering in human cells von Li, Songyuan, Akrap, Nina, Cerboni, Silvia, Porritt, Michelle J., Wimberger, Sandra, Lundin, Anders, Möller, Carl, Firth, Mike, Gordon, Euan, Lazovic, Bojana, Sieńska, Aleksandra, Pane, Luna Simona, Coelho, Matthew A., Ciotta, Giovanni, Pellegrini, Giovanni, Sini, Marcella, Xu, Xiufeng, Mitra, Suman, Bohlooly-Y, Mohammad, Taylor, Benjamin J. M., Sienski, Grzegorz, Maresca, Marcello

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A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo von Bestas, Burcu, Wimberger, Sandra, Degtev, Dmitrii, Madsen, Alexandra, Rottner, Antje K., Karlsson, Fredrik, Naumenko, Sergey, Callahan, Megan, Touza, Julia Liz, Francescatto, Margherita, Möller, Carl Ivar, Badertscher, Lukas, Li, Songyuan, Cerboni, Silvia, Selfjord, Niklas, Ericson, Elke, Gordon, Euan, Firth, Mike, Chylinski, Krzysztof, Taheri-Ghahfarokhi, Amir, Bohlooly-Y, Mohammad, Snowden, Mike, Pangalos, Menelaos, Nuttall, Barrett, Akcakaya, Pinar, Sienski, Grzegorz, Maresca, Marcello

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Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes von Zabulica, Mihaela, Srinivasan, Raghuraman C., Akcakaya, Pinar, Allegri, Gabriella, Bestas, Burcu, Firth, Mike, Hammarstedt, Christina, Jakobsson, Tomas, Jakobsson, Towe, Ellis, Ewa, Jorns, Carl, Makris, Georgios, Scherer, Tanja, Rimann, Nicole, van Zuydam, Natalie R., Gramignoli, Roberto, Forslöw, Anna, Engberg, Susanna, Maresca, Marcello, Rooyackers, Olav, Thöny, Beat, Häberle, Johannes, Rosen, Barry, Strom, Stephen C.

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Therapeutic Genome Editing With CRISPR/Cas9 in a Humanized Mouse Model Ameliorates α1-antitrypsin Deficiency Phenotype von Bjursell, Mikael, Porritt, Michelle J., Ericson, Elke, Taheri-Ghahfarokhi, Amir, Clausen, Maryam, Magnusson, Lisa, Admyre, Therese, Nitsch, Roberto, Mayr, Lorenz, Aasehaug, Leif, Seeliger, Frank, Maresca, Marcello, Bohlooly-Y, Mohammad, Wiseman, John

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Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons von Robbins, Jacqueline P, Perfect, Leo, Ribe, Elena M, Maresca, Marcello, Dangla-Valls, Adrià, Foster, Evangeline M, Killick, Richard, Nowosiad, Paulina, Reid, Matthew J, Polit, Lucia Dutan, Nevado, Alejo J, Ebner, Daniel, Bohlooly-Y, Mohammad, Buckley, Noel, Pangalos, Menelas N, Price, Jack, Lovestone, Simon

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High-efficiency counterselection recombineering for site-directed mutagenesis in bacterial artificial chromosomes von Bird, Alexander W, Erler, Axel, Fu, Jun, Hériché, Jean-Karim, Maresca, Marcello, Zhang, Youming, Hyman, Anthony A, Stewart, A Francis

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Axl receptor tyrosine kinase is a regulator of apolipoprotein E von Zhao, Wenchen, Fan, Jianjia, Kulic, Iva, Koh, Cheryl, Clark, Amanda, Meuller, Johan, Engkvist, Ola, Barichievy, Samantha, Raynoschek, Carina, Hicks, Ryan, Maresca, Marcello, Wang, Qi, Brown, Dean G, Lok, Alvin, Parro, Cameron, Robert, Jerome, Chou, Hsien-Ya, Zuhl, Andrea M, Wood, Michael W, Brandon, Nicholas J, Wellington, Cheryl L

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NKX6.1 induced pluripotent stem cell reporter lines for isolation and analysis of functionally relevant neuronal and pancreas populations von Gupta, Shailesh Kumar, Wesolowska-Andersen, Agata, Ringgaard, Anna K., Jaiswal, Himjyot, Song, Luyan, Hastoy, Benoit, Ingvorsen, Camilla, Taheri-Ghahfarokhi, Amir, Magnusson, Björn, Maresca, Marcello, Jensen, Rikke R., Beer, Nicola L., Fels, Johannes J., Grunnet, Lars G., Thomas, Melissa K., Gloyn, Anna L., Hicks, Ryan, McCarthy, Mark I., Hansson, Mattias, Honoré, Christian

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