Serine is a natural ligand and allosteric activator of pyruvate kinase M2 von Chaneton, Barbara, Hillmann, Petra, Zheng, Liang, Martin, Agnès C. L., Maddocks, Oliver D. K., Chokkathukalam, Achuthanunni, Coyle, Joseph E., Jankevics, Andris, Holding, Finn P., Vousden, Karen H., Frezza, Christian, O’Reilly, Marc, Gottlieb, Eyal

Volltext

Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design von O’Reilly, Marc, Cleasby, Anne, Davies, Thomas G., Hall, Richard J., Ludlow, R. Frederick, Murray, Christopher W., Tisi, Dominic, Jhoti, Harren

Volltext

X‑ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor von St. Denis, Jeffrey D., Chessari, Gianni, Cleasby, Anne, Cons, Benjamin D., Cowan, Suzanna, Dalton, Samuel E., East, Charlotte, Murray, Christopher W., O’Reilly, Marc, Peakman, Torren, Rapti, Magdalini, Stow, Jessie L.

Volltext

Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2 von Kidger, Andrew M, Munck, Joanne M, Saini, Harpreet K, Balmanno, Kathryn, Minihane, Emma, Courtin, Aurelie, Graham, Brent, O'Reilly, Marc, Odle, Richard, Cook, Simon J

Volltext

Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity von Howard, Steven, Berdini, Valerio, Boulstridge, John A, Carr, Maria G, Cross, David M, Curry, Jayne, Devine, Lindsay A, Early, Theresa R, Fazal, Lynsey, Gill, Adrian L, Heathcote, Michelle, Maman, Sarita, Matthews, Julia E, McMenamin, Rachel L, Navarro, Eva F, O’Brien, Michael A, O’Reilly, Marc, Rees, David C, Reule, Matthias, Tisi, Dominic, Williams, Glyn, Vinković, Mladen, Wyatt, Paul G

Volltext

Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β‑Glucocerebrosidase von Palmer, Nick, Agnew, Christopher, Benn, Caroline, Buffham, William J., Castro, Joan N., Chessari, Gianni, Clark, Mellissa, Cons, Benjamin D., Coyle, Joseph E., Dawson, Lee A., Hamlett, Christopher C. F., Hodson, Charlotte, Holding, Finn, Johnson, Christopher N., Liebeschuetz, John W., Mahajan, Pravin, McCarthy, James M., Murray, Christopher W., O’Reilly, Marc, Peakman, Torren, Price, Amanda, Rapti, Magdalini, Reeks, Judith, Schöpf, Patrick, St-Denis, Jeffrey D., Valenzano, Chiara, Wallis, Nicola G., Walser, Reto, Weir, Heather, Wilsher, Nicola E., Woodhead, Andrew, Bento, Carla F., Tisi, Dominic

Volltext

ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK von Munck, Joanne M, Berdini, Valerio, Bevan, Luke, Brothwood, Jessica L, Castro, Juan, Courtin, Aurélie, East, Charlotte, Ferraldeschi, Roberta, Heightman, Tom D, Hindley, Christopher J, Kucia-Tran, Justyna, Lyons, John F, Martins, Vanessa, Muench, Sandra, Murray, Christopher W, Norton, David, O'Reilly, Marc, Reader, Michael, Rees, David C, Rich, Sharna J, Richardson, Caroline J, Shah, Alpesh D, Stanczuk, Lukas, Thompson, Neil T, Wilsher, Nicola E, Woolford, Alison J-A, Wallis, Nicola G

Volltext

Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2 von Heightman, Tom D, Berdini, Valerio, Braithwaite, Hannah, Buck, Ildiko M, Cassidy, Megan, Castro, Juan, Courtin, Aurélie, Day, James E. H, East, Charlotte, Fazal, Lynsey, Graham, Brent, Griffiths-Jones, Charlotte M, Lyons, John F, Martins, Vanessa, Muench, Sandra, Munck, Joanne M, Norton, David, O’Reilly, Marc, Palmer, Nick, Pathuri, Puja, Reader, Michael, Rees, David C, Rich, Sharna J, Richardson, Caroline, Saini, Harpreet, Thompson, Neil T, Wallis, Nicola G, Walton, Hugh, Wilsher, Nicola E, Woolford, Alison J.-A, Cooke, Michael, Cousin, David, Onions, Stuart, Shannon, Jonathan, Watts, John, Murray, Christopher W

Volltext

Crystal structure of human CDK4 in complex with a D-type cyclin von Day, Philip J, Cleasby, Anne, Tickle, Ian J, O'Reilly, Marc, Coyle, Joe E, Holding, Finn P, McMenamin, Rachel L, Yon, Jeff, Chopra, Rajiv, Lengauer, Christoph, Jhoti, Harren

Volltext

Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2 von Heightman, Tom D, Berdini, Valerio, Bevan, Luke, Buck, Ildiko M, Carr, Maria G, Courtin, Aurélie, Coyle, Joseph E, Day, James E H, East, Charlotte, Fazal, Lynsey, Griffiths-Jones, Charlotte M, Howard, Steven, Kucia-Tran, Justyna, Martins, Vanessa, Muench, Sandra, Munck, Joanne M, Norton, David, O'Reilly, Marc, Palmer, Nicholas, Pathuri, Puja, Peakman, Torren M, Reader, Michael, Rees, David C, Rich, Sharna J, Shah, Alpesh, Wallis, Nicola G, Walton, Hugh, Wilsher, Nicola E, Woolford, Alison J-A, Cooke, Michael, Cousin, David, Onions, Stuart, Shannon, Jonathan, Watts, John, Murray, Christopher W

Volltext

Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallog... von Wyatt, Paul G, Woodhead, Andrew J, Berdini, Valerio, Boulstridge, John A, Carr, Maria G, Cross, David M, Davis, Deborah J, Devine, Lindsay A, Early, Theresa R, Feltell, Ruth E, Lewis, E. Jonathan, McMenamin, Rachel L, Navarro, Eva F, O’Brien, Michael A, O’Reilly, Marc, Reule, Matthias, Saxty, Gordon, Seavers, Lisa C. A, Smith, Donna-Michelle, Squires, Matt S, Trewartha, Gary, Walker, Margaret T, Woolford, Alison J.-A

Volltext

Fragment-based approaches to the discovery of kinase inhibitors von Mortenson, Paul N, Berdini, Valerio, O'Reilly, Marc

Volltext

4-(Pyrazol-4-yl)-pyrimidines as Selective Inhibitors of Cyclin-Dependent Kinase 4/6 von Cho, Young Shin, Borland, Maria, Brain, Christopher, Chen, Christine H.-T, Cheng, Hong, Chopra, Rajiv, Chung, Kristy, Groarke, James, He, Guo, Hou, Ying, Kim, Sunkyu, Kovats, Steven, Lu, Yipin, O’Reilly, Marc, Shen, Junqing, Smith, Troy, Trakshel, Gary, Vögtle, Markus, Xu, Mei, Xu, Ming, Sung, Moo Je

Volltext

Empires: Varying, Enduring, Controversial von O'Reilly, Marc J.

Volltext

Biochemical and biophysical characterization of pyruvate kinase M2 activation by L-serine von Chaneton, Barbara, Holding, Finn, Hold, Adam, Van Der Reest, Jiska, Marciano, Gabriele, O’Reilly, Marc, Gottlieb, Eyal

Volltext

Telomerases von O’Reilly, Marc, Teichmann, Sarah A, Rhodes, Daniela

Volltext

Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design von Mukherjee, Manjeet, Day, Philip J., Laverty, Duncan, Bueren-Calabuig, Juan A., Woodhead, Andrew J., Griffiths-Jones, Charlotte, Hiscock, Steve, East, Charlotte, Boyd, Susan, O'Reilly, Marc

Volltext

The Association of Gastrocnemius Tightness, Genu Valgum and Hallux Valgus: A Prospective Case-Control Study von O’ Reilly, Marc, Merghani, Khalid, McKenna, Johnny, Bayer, Thomas

Volltext

Evolving Empire: America's "Emirates" Strategy in the Persian Gulf von O'REILLY, MARC J., RENFRO, WESLEY B.

Volltext

Engineering and purification of a thermostable, high-yield, variant of PfCRT, the Plasmodium falciparum chloroquine resistance transporter von Wright, David J., O'Reilly, Marc, Tisi, Dominic

Volltext