Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody von Stewart, Ross, Morrow, Michelle, Hammond, Scott A, Mulgrew, Kathy, Marcus, Danielle, Poon, Edmund, Watkins, Amanda, Mullins, Stefanie, Chodorge, Matthieu, Andrews, John, Bannister, David, Dick, Emily, Crawford, Nicola, Parmentier, Julie, Alimzhanov, Marat, Babcook, John S, Foltz, Ian N, Buchanan, Andrew, Bedian, Vahe, Wilkinson, Robert W, McCourt, Matthew

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The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors von Hedvat, Michael, Huszar, Dennis, Herrmann, Andreas, Gozgit, Joseph M., Schroeder, Anne, Sheehy, Adam, Buettner, Ralf, Proia, David, Kowolik, Claudia M., Xin, Hong, Armstrong, Brian, Bebernitz, Geraldine, Weng, Shaobu, Wang, Lin, Ye, Minwei, McEachern, Kristen, Chen, Huawei, Morosini, Deborah, Bell, Kirsten, Alimzhanov, Marat, Ioannidis, Stephanos, McCoon, Patricia, Cao, Zhu A., Yu, Hua, Jove, Richard, Zinda, Michael

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B Cell-Specific Deletion of Protein-Tyrosine Phosphatase Shp1 Promotes B-1a Cell Development and Causes Systemic Autoimmunity von Pao, Lily I., Lam, Kong-Peng, Henderson, Joel M., Kutok, Jeffery L., Alimzhanov, Marat, Nitschke, Lars, Thomas, Matthew L., Neel, Benjamin G., Rajewsky, Klaus

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Complement C4 maintains peripheral B‐cell tolerance in a myeloid cell dependent manner von Chatterjee, Priyadarshini, Agyemang, Amma F., Alimzhanov, Marat B., Degn, Soren, Tsiftsoglou, Stefanos A., Alicot, Elisabeth, Jones, Sarah A., Ma, Minghe, Carroll, Michael C.

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FDC-Specific Functions of p55TNFR and IKK2 in the Development of FDC Networks and of Antibody Responses von Victoratos, Panayiotis, Lagnel, Jacques, Tzima, Sotiria, Alimzhanov, Marat B., Rajewsky, Klaus, Pasparakis, Manolis, Kollias, George

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Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching von Wang, Jing H, Alt, Frederick W, Gostissa, Monica, Datta, Abhishek, Murphy, Michael, Alimzhanov, Marat B, Coakley, Kristen M, Rajewsky, Klaus, Manis, John P, Yan, Catherine T

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Abnormal Development of Secondary Lymphoid Tissues in Lymphotoxin β -deficient Mice von Alimzhanov, Marat B., Kuprash, Dmitry V., Kosco-Vilbois, Marie H., Luz, Arne, Turetskaya, Regina L., Tarakhovsky, Alexander, Rajewsky, Klaus, Nedospasov, Sergei A., Pfeffer, Klaus

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757 M9657, a novel tumor-targeted conditional anti-CD137 agonist displays MSLN-dependent anti-tumor immunity von Xu, Chunxiao, Rabinovich, Brain, Deshpande, Amit, Zhou, Xueyuan, Pipp, Frederic Christian, Schweickhardt, Rene, Webb, Lindsay, Yalavarthi, Sireesha, Bourin, Clotilde, Ghatak, Payel, Safi, Barroq, Wollerton, Francisca, Brewis, Neil, Munoz-Olaya, Jose, Belousova, Natalya, Alimzhanov, Marat, Hubensack, Martina, Halle, Joern-Peter, Blaukat, Andree, Moisan, Jacques

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Complement C 4 maintains peripheral B ‐cell tolerance in a myeloid cell dependent manner von Chatterjee, Priyadarshini, Agyemang, Amma F., Alimzhanov, Marat B., Degn, Soren, Tsiftsoglou, Stefanos A., Alicot, Elisabeth, Jones, Sarah A., Ma, Minghe, Carroll, Michael C.

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Redundancy in Tumor Necrosis Factor (TNF) and Lymphotoxin (LT) Signaling In Vivo: Mice with Inactivation of the Entire TNF/LT Locus versus Single-Knockout Mice von Kuprash, Dmitry V., Alimzhanov, Marat B., Tumanov, Alexei V., Grivennikov, Sergei I., Shakhov, Alexander N., Drutskaya, Ludmila N., Marino, Michael W., Turetskaya, Regina L., Anderson, Arthur O., Rajewsky, Klaus, Pfeffer, Klaus, Nedospasov, Sergei A.

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Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer von Kraus, Manfred, Alimzhanov, Marat B., Rajewsky, Nikolaus, Rajewsky, Klaus

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Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway von Ioannidis, Stephanos, Lamb, Michelle L, Wang, Tao, Almeida, Lynsie, Block, Michael H, Davies, Audrey M, Peng, Bo, Su, Mei, Zhang, Hai-Jun, Hoffmann, Ethan, Rivard, Caroline, Green, Isabelle, Howard, Tina, Pollard, Hannah, Read, Jon, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Ye, Minwei, Huszar, Dennis, Zinda, Michael

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Abstract 964: Induction of immunogenic cell death and interferon signaling by carboplatin and the ATR inhibitor M6620 may contribute to anti-tumor activity of M6620-carboplatin-ave... von Alimzhanov, Marat, George, Ashwin, Shah, Parantu, Zimmerman, Astrid, Schroeder, Andreas, Falk, Martin, Amendt, Christiane, Halle, Joern-Peter, Blaukat, Andree, Zenke, Frank, Soulard, Patricia

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B cell receptor signal strength determines B cell fate von Casola, Stefano, Rajewsky, Klaus, Otipoby, Kevin L, Alimzhanov, Marat, Humme, Sibille, Uyttersprot, Nathalie, Kutok, Jeffery L, Carroll, Michael C

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Abstract 2269: ATR inhibitor M6620 enhances anti-tumor efficacy of the combination of the anti-PD-L1 antibody avelumab with platinum-based chemotherapy von Alimzhanov, Marat, Soulard, Patricia, Zimmermann, Astrid, Schroeder, Andreas, Mehr, Keyvan Tadjalli, Amendt, Christiane, Sim, Geok Choo, Blaukat, Andree, Halle, Joern-Peter, Zenke, Frank T.

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Discovery of 1-Methyl-1 H -imidazole Derivatives as Potent Jak2 Inhibitors von Su, Qibin, Ioannidis, Stephanos, Chuaqui, Claudio, Almeida, Lynsie, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Block, Michael, Howard, Tina, Huang, Shan, Huszar, Dennis, Read, Jon A., Rivard Costa, Caroline, Shi, Jie, Su, Mei, Ye, Minwei, Zinda, Michael

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Discovery of 5-Chloro-N 2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N 4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway von Ioannidis, Stephanos, Lamb, Michelle L, Wang, Tao, Almeida, Lynsie, Block, Michael H, Davies, Audrey M, Peng, Bo, Su, Mei, Zhang, Hai-Jun, Hoffmann, Ethan, Rivard, Caroline, Green, Isabelle, Howard, Tina, Pollard, Hannah, Read, Jon, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Ye, Minwei, Huszar, Dennis, Zinda, Michael

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Discovery of 1‑Methyl‑1H‑imidazole Derivatives as Potent Jak2 Inhibitors von Su, Qibin, Ioannidis, Stephanos, Chuaqui, Claudio, Almeida, Lynsie, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Block, Michael, Howard, Tina, Huang, Shan, Huszar, Dennis, Read, Jon A, Rivard Costa, Caroline, Shi, Jie, Su, Mei, Ye, Minwei, Zinda, Michael

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Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors von Grimster, Neil P, Anderson, Erica, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Chuaqui, Claudio, Deegan, Tracy, Ferguson, Andrew D, Gero, Thomas, Harsch, Andreas, Huszar, Dennis, Kawatkar, Aarti, Kettle, Jason G, Lyne, Paul, Read, Jon A, Rivard Costa, Caroline, Ruston, Linette, Schroeder, Patricia, Shi, Jie, Su, Qibin, Throner, Scott, Toader, Dorin, Vasbinder, Melissa, Woessner, Richard, Wang, Haixia, Wu, Allan, Ye, Minwei, Zheng, Weijia, Zinda, Michael

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Abstract 1692: Dalantercept, an ALK1 inhibitor of angiogenesis, in combination with cisplatin inhibits tumor growth in a xenograft model of squamous cell carcinoma of the head and... von Alimzhanov, Marat, Lee, Michael, Solban, Nicolas, Pearsall, Scott, Pandya, Susan, Sherman, Matthew L., Kumar, Ravindra

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