Discovery of a Potent, Selective, and Orally Active Human Epidermal Growth Factor Receptor-2 Sheddase Inhibitor for the Treatment of Cancer von Yao, Wenqing, Zhuo, Jincong, Burns, David M, Xu, Meizhong, Zhang, Colin, Li, Yun-Long, Qian, Ding-Quan, He, Chunhong, Weng, Lingkai, Shi, Eric, Lin, Qiyan, Agrios, Costas, Burn, Timothy C, Caulder, Eian, Covington, Maryanne B, Fridman, Jordan S, Friedman, Steven, Katiyar, Kamna, Hollis, Gregory, Li, Yanlong, Liu, Changnian, Liu, Xiangdong, Marando, Cindy A, Newton, Robert, Pan, Max, Scherle, Peggy, Taylor, Nancy, Vaddi, Kris, Wasserman, Zelda R, Wynn, Richard, Yeleswaram, Swamy, Jalluri, Ravi, Bower, Michael, Zhou, Bing-Bing, Metcalf, Brian

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Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P'1 permutations von BURNS, David M, CHUNHONG HE, FRIDMAN, Jordan S, HOLLIS, Gregory, VADDI, Kris, YELESWARAM, Swamy, NEWTON, Robert, FRIEDMAN, Steve, METCALF, Brian, WENQING YAO, YANLONG LI, SCHERLE, Peggy, XIANGDONG LIU, MARANDO, Cindy A, COVINGTON, Mayanne B, GENGJIE YANG, PAN, Max, TURNER, Sharon

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Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibit... von Burns, David M., Li, Yun-Long, Shi, Eric, He, Chunhong, Xu, Meizhong, Zhuo, Jincong, Zhang, Colin, Qian, Ding-Quan, Li, Yanlong, Wynn, Richard, Covington, Maryanne B., Katiyar, Kamna, Marando, Cindy A., Fridman, Jordan S., Scherle, Peggy, Friedman, Steve, Metcalf, Brian, Yao, Wenqing

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Design and identification of selective HER-2 sheddase inhibitors via P1′ manipulation and unconventional P2′ perturbations to induce a molecular metamorphosis von Yao, Wenqing, Zhuo, Jincong, Burns, David M., Li, Yun-Long, Qian, Ding-Quan, Zhang, Colin, He, Chunhong, Xu, Meizhong, Shi, Eric, Li, Yanlong, Marando, Cindy A., Covington, Maryanne B., Yang, Gengjie, Liu, Xiangdong, Pan, Max, Fridman, Jordan S., Scherle, Peggy, Wasserman, Zelda R., Hollis, Gregory, Vaddi, Kris, Yeleswaram, Swamy, Newton, Robert, Friedman, Steve, Metcalf, Brian

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Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle permutations von Burns, David M., He, Chunhong, Li, Yanlong, Scherle, Peggy, Liu, Xiangdong, Marando, Cindy A., Covington, Mayanne B., Yang, Gengjie, Pan, Max, Turner, Sharon, Fridman, Jordan S., Hollis, Gregory, Vaddi, Kris, Yeleswaram, Swamy, Newton, Robert, Friedman, Steve, Metcalf, Brian, Yao, Wenqing

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Liver transplantation as definitive treatment for a factor V Leiden mutation von Dunn, Stephen P., Tsai, Anthony, Griffin, Gregory, Toth, Stephen, Casas-Melley, Adela T., Falkenstein, Kathleen P., Marando, Cindy A., Krueger, Leslie J.

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Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P 1 ′ permutations von Burns, David M., He, Chunhong, Li, Yanlong, Scherle, Peggy, Liu, Xiangdong, Marando, Cindy A., Covington, Mayanne B., Yang, Gengjie, Pan, Max, Turner, Sharon, Fridman, Jordan S., Hollis, Gregory, Vaddi, Kris, Yeleswaram, Swamy, Newton, Robert, Friedman, Steve, Metcalf, Brian, Yao, Wenqing

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Corrigendum to “Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2... von Burns, David M., Li, Yun-Long, Xu, Meizhong, Shi, Eric, He, Chunhong, Zhuo, Jincong, Zhang, Colin, Qian, Ding-Quan, Li, Yanlong, Wynn, Richard, Covington, Maryanne B., Katiyar, Kamna, Marando, Cindy A., Fridman, Jordan S., Scherle, Peggy, Friedman, Steve, Metcalf, Brian, Yao, Wenqing

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Liver transplantation as definitive treatment for A factory V Leiden mutation von DUNN, Stephen P, TSAI, Anthony, GRIFFIN, Gregory, TOTH, Stephen, CASAS-MELLEY, Adela T, FALKENSTEIN, Kathleen P, MARANDO, Cindy A, KRUEGER, Leslie J

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Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies von Koblish, Holly, Li, Yun-Long, Shin, Niu, Hall, Leslie, Wang, Qian, Wang, Kathy, Covington, Maryanne, Marando, Cindy, Bowman, Kevin, Boer, Jason, Burke, Krista, Wynn, Richard, Margulis, Alex, Reuther, Gary W, Lambert, Que T, Dostalik Roman, Valerie, Zhang, Ke, Feng, Hao, Xue, Chu-Biao, Diamond, Sharon, Hollis, Greg, Yeleswaram, Swamy, Yao, Wenqing, Huber, Reid, Vaddi, Kris, Scherle, Peggy

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Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor von Koblish, Holly K, Wu, Liangxing, Wang, Liang-Chuan S, Liu, Phillip C C, Wynn, Richard, Rios-Doria, Jonathan, Spitz, Susan, Liu, Hao, Volgina, Alla, Zolotarjova, Nina, Kapilashrami, Kanishk, Behshad, Elham, Covington, Maryanne, Yang, Yan-Ou, Li, Jingwei, Diamond, Sharon, Soloviev, Maxim, O'Hayer, Kevin, Rubin, Stephen, Kanellopoulou, Chrysi, Yang, Gengjie, Rupar, Mark, DiMatteo, Darlise, Lin, Luping, Stevens, Christina, Zhang, Yue, Thekkat, Pramod, Geschwindt, Ryan, Marando, Cindy, Yeleswaram, Swamy, Jackson, Jeff, Scherle, Peggy, Huber, Reid, Yao, Wenqing, Hollis, Gregory

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A Novel Kinase Inhibitor, INCB28060, Blocks c-MET-Dependent Signaling, Neoplastic Activities, and Cross-Talk with EGFR and HER-3 von XIANGDONG LIU, QIAN WANG, BOER, Jason, DIAMOND, Sharon, CHUNHONG HE, MEIZHONG XU, JINCONG ZHUO, WENQING YAO, NEWTON, Robert C, SCHERLE, Peggy A, GENGJIE YANG, MARANDO, Cindy, KOBLISH, Holly K, HALL, Leslie M, FRIDMAN, Jordan S, BEHSHAD, Elham, WYNN, Richard, YU LI

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Discovery of 1′-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3′-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 1... von Zhang, Colin, Xu, Meizhong, He, Chunhong, Zhuo, Jincong, Burns, David M., Qian, Ding-Quan, Lin, Qiyan, Li, Yun-Long, Chen, Lihua, Shi, Eric, Agrios, Costas, Weng, Linkai, Sharief, Vaqar, Jalluri, Ravi, Li, Yanlong, Scherle, Peggy, Diamond, Sharon, Hunter, Deborah, Covington, Maryanne, Marando, Cindy, Wynn, Richard, Katiyar, Kamna, Contel, Nancy, Vaddi, Kris, Yeleswaram, Swamy, Hollis, Gregory, Huber, Reid, Friedman, Steve, Metcalf, Brian, Yao, Wenqing

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Phase 1/2 Study of the Pan-PIM Kinase Inhibitor INCB053914 Alone or in Combination With Standard-of-Care Agents in Patients With Advanced Hematologic Malignancies von Patel, Manish R., Donnellan, William, Byrne, Michael, Asch, Adam S., Zeidan, Amer M., Baer, Maria R., Fathi, Amir T., Kuykendall, Andrew T., Zheng, Fred, Walker, Chris, Cheng, Lulu, Marando, Cindy, Savona, Michael R.

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Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells von Liu, Phillip C.C., Liu, Xiangdong, Li, Yanlong, Covington, Maryanne, Wynn, Richard, Huber, Reid, Hillman, Milton, Yang, Gengjie, Ellis, Dawn, Marando, Cindy, Katiyar, Kamna, Bradley, Jodi, Abremski, Kenneth, Stow, Mark, Rupar, Mark, Zhuo, Jincong, Li, Yun-Long, Lin, Qiyan, Burns, David, Xu, Meizhong, Zhang, Colin, Qian, Ding-Quan, He, Chunhong, Sharief, Vaqar, Weng, Lingkai, Agrios, Costas, Shi, Eric, Metcalf, Brian, Newton, Robert, Friedman, Steven, Yao, Wenqing, Scherle, Peggy A., Hollis, Gregory, Burn, Timothy C.

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Abstract 5071: Preclinical characterization of the potent and selective BET inhibitor INCB057643 in models of hematologic malignancies von Stubbs, Matthew C., Maduskuie, Thomas, Burn, Timothy, Diamond-Fosbenner, Sharon, Falahatpisheh, Nikoo, Volgina, Alla, Zolotarjova, Nina, Wen, Xiaoming, Feldman, Patricia, Rupar, Mark, Collins, Robert, Marando, Cindy, Ruggeri, Bruce, Covington, Maryanne, Liu, Xuesong Mike, Wynn, Richard, Yeleswaram, Swamy, Yao, Wenqing, Huber, Reid, Hollis, Gregory, Scherle, Peggy, Combs, Andrew P., Liu, Phillip C.

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Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab von Liu, Xiangdong, Fridman, Jordan S., Wang, Qian, Caulder, Eian, Yang, Gengjie, Covington, Maryanne, Liu, Changnian, Marando, Cindy, Zhuo, Jincong, Li, Yanlong, Yao, Wenqing, Vaddi, Kris, Newton, Robert C., Scherle, Peggy A., Friedman, Steven M.

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Abstract 5414: Activity of the pan-PIM kinase inhibitor INCB053914 in models of multiple myeloma von Koblish, Holly, Shin, Niu, Hall, Leslie, Wen, Xiaoming, O'Connor, Sybil, Dostalik, Valerie, Wang, Qian, Wang, Kathy, Covington, Maryanne, Marando, Cindy, Bowman, Kevin, Boer, Jason, Burke, Krista, Zhang, Ke, Feng, Hao, Xue, Chu-Biao, Li, Yun-Long, Yao, Wenqing, Huber, Reid, Vaddi, Kris, Scherle, Peggy

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Abstract 5397: Characterization of INCB053914, a novel pan-PIM kinase inhibitor von Shin, Niu, Covington, Maryanne, Wynn, Richard, Li, Yanlong, Margulis, Alexander, Wang, Qian, Wang, Kathy, Marando, Cindy, Feldman, Patricia, Leffet, Lynn, Gallagher, Karen, He, Xin, Chang, Hong, Zhang, He, Feng, Hao, Li, Yun-Long, Xue, Chu-Biao, Yao, Wenqing, Burn, Timothy, Vaddi, Kris, Diamond-Fosbenner, Sharon, Yeleswaram, Swamy, Hollis, Gregory, Newton, Robert, Huber, Reid, Scherle, Peggy, Koblish, Holly

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Analysis of Epstein-Barr virus reservoirs in paired blood and breast cancer primary biopsy specimens by real time PCR von Perkins, R Serene, Sahm, Katherine, Marando, Cindy, Dickson-Witmer, Diana, Pahnke, Gregory R, Mitchell, Mark, Petrelli, Nicholas J, Berkowitz, Irving M, Soteropoulos, Patricia, Aris, Virginie M, Dunn, Stephen P, Krueger, Leslie J

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