Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation von Abdel-Hakeem, Mohamed S., Manne, Sasikanth, Beltra, Jean-Christophe, Stelekati, Erietta, Chen, Zeyu, Nzingha, Kito, Ali, Mohammed-Alkhatim, Johnson, John L., Giles, Josephine R., Mathew, Divij, Greenplate, Allison R., Vahedi, Golnaz, Wherry, E. John

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A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma von Huang, Alexander C., Orlowski, Robert J., Xu, Xiaowei, Mick, Rosemarie, George, Sangeeth M., Yan, Patrick K., Manne, Sasikanth, Kraya, Adam A., Wubbenhorst, Bradley, Dorfman, Liza, D’Andrea, Kurt, Wenz, Brandon M., Liu, Shujing, Chilukuri, Lakshmi, Kozlov, Andrew, Carberry, Mary, Giles, Lydia, Kier, Melanie W., Quagliarello, Felix, McGettigan, Suzanne, Kreider, Kristin, Annamalai, Lakshmanan, Zhao, Qing, Mogg, Robin, Xu, Wei, Blumenschein, Wendy M., Yearley, Jennifer H., Linette, Gerald P., Amaravadi, Ravi K., Schuchter, Lynn M., Herati, Ramin S., Bengsch, Bertram, Nathanson, Katherine L., Farwell, Michael D., Karakousis, Giorgos C., Wherry, E. John, Mitchell, Tara C.

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Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity von Liu, Chang, Somasundaram, Ashwin, Manne, Sasikanth, Gocher, Angela M., Szymczak-Workman, Andrea L., Vignali, Kate M., Scott, Ellen N., Normolle, Daniel P., John Wherry, E., Lipson, Evan J., Ferris, Robert L., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A. A.

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miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb von Chen, Zeyu, Stelekati, Erietta, Kurachi, Makoto, Yu, Sixiang, Cai, Zhangying, Manne, Sasikanth, Khan, Omar, Yang, Xiaolu, Wherry, E. John

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Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation von Abdel-Hakeem, Mohamed S., Manne, Sasikanth, Beltra, Jean-Christophe, Stelekati, Erietta, Chen, Zeyu, Nzingha, Kito, Ali, Mohammed-Alkhatim, Johnson, John L., Giles, Josephine R., Mathew, Divij, Greenplate, Allison R., Vahedi, Golnaz, Wherry, E. John

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Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways von Herati, Ramin Sedaghat, Silva, Luisa Victoria, Vella, Laura A., Muselman, Alexander, Alanio, Cecile, Bengsch, Bertram, Kurupati, Raj K., Kannan, Senthil, Manne, Sasikanth, Kossenkov, Andrew V., Canaday, David H., Doyle, Susan A., Ertl, Hildegund C.J., Schmader, Kenneth E., Wherry, E. John

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Notch transactivates Rheb to maintain the multipotency of TSC-null cells von Cho, Jun-Hung, Patel, Bhaumik, Bonala, Santosh, Manne, Sasikanth, Zhou, Yan, Vadrevu, Surya K., Patel, Jalpa, Peronaci, Marco, Ghouse, Shanawaz, Henske, Elizabeth P., Roegiers, Fabrice, Giannikou, Krinio, Kwiatkowski, David J., Mansouri, Hossein, Markiewski, Maciej M., White, Brandon, Karbowniczek, Magdalena

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253 PD1 and LAG3 converge to limit polyfunctionality and systemic immunity von Andrews, Lawrence, Manne, Sasikanth, John Wherry, E, Workman, Creg, Vignali, Dario

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1016 Enforcement of exhausted T cell epigenetic fate by HMG-box transcription factor TOX von Huang, Yinghui Jane, Giles, Josephine R, Ngiow, Shin Foong, Baxter, Amy E, Manne, Sasikanth, Khan, Omar, Park, Simone L, Wu, Jennifer E, John Wherry, E

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Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection von Henrickson, Sarah E., Manne, Sasikanth, Dolfi, Douglas V., Mansfield, Kathleen D., Parkhouse, Kaela, Mistry, Rakesh D., Alpern, Elizabeth R., Hensley, Scott E., Sullivan, Kathleen E., Coffin, Susan E., Wherry, E. John

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310 T cell intrinsic DNA damage and repair response as a novel marker associated with clinical response to PD-1 blockade von Muroyama, Yuki, Manne, Sasikanth, Greenplate, Allison, Mathew, Divij, Oldridge, Derek, Chilukuri, Lakshmi, Xu, Caiyue, Herati, Ramin, Huang, Alexander, Zamarin, Dimitriy, Friedman, Claire, John Wherry, E

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579-C Reinvigoration of progenitor-exhausted CD8 T cells by anti-CTLA-4 contributes to the sustained activity of combination checkpoint blockade von Wang, Kevin, Coutifaris, Paulina, Brocks, David, Solis, Sabrina, Han, Nicholas, Manne, Sasikanth, Kiner, Evgeny, Sachar, Chirag, George, Sangeeth, Yan, Patrick, Kiner, Melanie W, Laughlin, Amy I, Kothari, Shawn, Giles, Josephine R, Mathew, Divij, Ghinnagow, Rheem, Alanio, Cecile, Flowers, Ahron, Xu, Wei, Tenney, Daniel, Xu, Xiaowei, Amaravadi, Ravi K, Karakousis, Giorgos C, Schuchter, Lynn M, Buggert, Marcus, John Wherry, E, Minn, Andy, Weber, Jeffrey, Mitchell, Tara, Herati, Ramin S, Huang, Alexander

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186 Distinct immune signatures predicting clinical response to PD-1 blockade therapy in gynecological cancers revealed by high-dimensional immune profiling von Muroyama, Yuki, Manne, Sasikanth, Huang, Alexandar, Mathew, Divij, Chilukuri, Lakshmi, Greenplate, Allison, Ohtani, Takuya, Zamarin, Dmitriy, Friedman, Claire, Wherry, John

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Metabolic and Deep Immune Profiling Reveal Coordinate Effects on Immune Function in Asthma and Obesity von Henrickson, Sarah E., MD, PhD, Manne, Sasikanth, MA, Herati, Ramin S., MD, MPH, Vella, Laura A., MD, PhD, Bengsch, Bertram, MD, PhD, Hensley, Scott E., PhD, Rabinowitz, Joshua D., PhD, Coffin, Susan, MD, MPH, Wherry, E. John, PhD

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TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion von Khan, Omar, Giles, Josephine R., McDonald, Sierra, Manne, Sasikanth, Ngiow, Shin Foong, Patel, Kunal P., Werner, Michael T., Huang, Alexander C., Alexander, Katherine A., Wu, Jennifer E., Attanasio, John, Yan, Patrick, George, Sangeeth M., Bengsch, Bertram, Staupe, Ryan P., Donahue, Greg, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Kaye, Jonathan, Berger, Shelley L., Wherry, E. John

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Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms von Beltra, Jean-Christophe, Manne, Sasikanth, Abdel-Hakeem, Mohamed S., Kurachi, Makoto, Giles, Josephine R., Chen, Zeyu, Casella, Valentina, Ngiow, Shin Foong, Khan, Omar, Huang, Yinghui Jane, Yan, Patrick, Nzingha, Kito, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Huang, Alexander C., Wherry, E. John

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Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications von Mathew, Divij, Giles, Josephine R, Baxter, Amy E, Oldridge, Derek A, Greenplate, Allison R, Wu, Jennifer E, Alanio, Cécile, Kuri-Cervantes, Leticia, Pampena, M Betina, D'Andrea, Kurt, Manne, Sasikanth, Chen, Zeyu, Huang, Yinghui Jane, Reilly, John P, Weisman, Ariel R, Ittner, Caroline A G, Kuthuru, Oliva, Dougherty, Jeanette, Nzingha, Kito, Han, Nicholas, Kim, Justin, Pattekar, Ajinkya, Goodwin, Eileen C, Anderson, Elizabeth M, Weirick, Madison E, Gouma, Sigrid, Arevalo, Claudia P, Bolton, Marcus J, Chen, Fang, Lacey, Simon F, Ramage, Holly, Cherry, Sara, Hensley, Scott E, Apostolidis, Sokratis A, Huang, Alexander C, Vella, Laura A, Betts, Michael R, Meyer, Nuala J, Wherry, E John

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TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision von Chen, Zeyu, Ji, Zhicheng, Ngiow, Shin Foong, Manne, Sasikanth, Cai, Zhangying, Huang, Alexander C., Johnson, John, Staupe, Ryan P., Bengsch, Bertram, Xu, Caiyue, Yu, Sixiang, Kurachi, Makoto, Herati, Ramin S., Vella, Laura A., Baxter, Amy E., Wu, Jennifer E., Khan, Omar, Beltra, Jean-Christophe, Giles, Josephine R., Stelekati, Erietta, McLane, Laura M., Lau, Chi Wai, Yang, Xiaolu, Berger, Shelley L., Vahedi, Golnaz, Ji, Hongkai, Wherry, E. John

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Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells von Bengsch, Bertram, Ohtani, Takuya, Khan, Omar, Setty, Manu, Manne, Sasikanth, O’Brien, Shaun, Gherardini, Pier Federico, Herati, Ramin Sedaghat, Huang, Alexander C., Chang, Kyong-Mi, Newell, Evan W., Bovenschen, Niels, Pe’er, Dana, Albelda, Steven M., Wherry, E. John

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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade von Pauken, Kristen E., Sammons, Morgan A., Odorizzi, Pamela M., Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M., Chen, Zeyu, Sen, Debattama R., Kurachi, Makoto, Barnitz, R. Anthony, Bartman, Caroline, Bengsch, Bertram, Huang, Alexander C., Schenkel, Jason M., Vahedi, Golnaz, Haining, W. Nicholas, Berger, Shelley L., Wherry, E. John

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