Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib von Weisberg, E, Azab, A K, Manley, P W, Kung, A L, Christie, A L, Bronson, R, Ghobrial, I M, Griffin, J D

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Imatinib: a selective tyrosine kinase inhibitor von Manley, P.W., Cowan-Jacob, S.W., Buchdunger, E., Fabbro, D., Fendrich, G., Furet, P., Meyer, T., Zimmermann, J.

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Midostaurin: a magic bullet that blocks mast cell expansion and activation von Valent, P., Akin, C., Hartmann, K., George, T.I., Sotlar, K., Peter, B., Gleixner, K.V., Blatt, K., Sperr, W.R., Manley, P.W., Hermine, O., Kluin-Nelemans, H.C., Arock, M., Horny, H.-P., Reiter, A., Gotlib, J.

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New Anilinophthalazines as Potent and Orally Well Absorbed Inhibitors of the VEGF Receptor Tyrosine Kinases Useful as Antagonists of Tumor-Driven Angiogenesis von Bold, Guido, Altmann, Karl-Heinz, Frei, Jörg, Lang, Marc, Manley, Paul W, Traxler, Peter, Wietfeld, Bernhard, Brüggen, Josef, Buchdunger, Elisabeth, Cozens, Robert, Ferrari, Stefano, Furet, Pascal, Hofmann, Francesco, Martiny-Baron, Georg, Mestan, Jürgen, Rösel, Johannes, Sills, Matthew, Stover, David, Acemoglu, Figan, Boss, Eugen, Emmenegger, René, Lässer, Laurent, Masso, Elvira, Roth, Rosemarie, Schlachter, Christian, Vetterli, Werner, Wyss, Dominique, Wood, Jeanette M

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Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth von Peter, B, Winter, G E, Blatt, K, Bennett, K L, Stefanzl, G, Rix, U, Eisenwort, G, Hadzijusufovic, E, Gridling, M, Dutreix, C, Hoermann, G, Schwaab, J, Radia, D, Roesel, J, Manley, P W, Reiter, A, Superti-Furga, G, Valent, P

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Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl von Weisberg, Ellen, Manley, Paul W., Breitenstein, Werner, Brüggen, Josef, Cowan-Jacob, Sandra W., Ray, Arghya, Huntly, Brian, Fabbro, Doriano, Fendrich, Gabriele, Hall-Meyers, Elizabeth, Kung, Andrew L., Mestan, Jürgen, Daley, George Q., Callahan, Linda, Catley, Laurie, Cavazza, Cara, Mohammed, Azam, Neuberg, Donna, Wright, Renee D., Gilliland, D. Gary, Griffin, James D.

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Synergistic growth-inhibitory effects of two tyrosine kinase inhibitors, dasatinib and PKC412, on neoplastic mast cells expressing the D816V-mutated oncogenic variant of KIT von Gleixner, Karoline V, Mayerhofer, Matthias, Sonneck, Karoline, Gruze, Alexander, Samorapoompichit, Puchit, Baumgartner, Christian, Lee, Francis Y, Aichberger, Karl J, Manley, Paul W, Fabbro, Doriano, Pickl, Winfried F, Sillaber, Christian, Valent, Peter

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PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease von Cools, Jan, Stover, Elizabeth H, Boulton, Christina L, Gotlib, Jason, Legare, Robert D, Amaral, Sonia M, Curley, David P, Duclos, Nicole, Rowan, Rebecca, Kutok, Jeffery L, Lee, Benjamin H, Williams, Ifor R, Coutre, Steven E, Stone, Richard M, DeAngelo, Daniel J, Marynen, Peter, Manley, Paul W, Meyer, Thomas, Fabbro, Doriano, Neuberg, Donna, Weisberg, Ellen, Griffin, James D, Gilliland, D.Gary

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Binding of the K+ channel opener [3H]P1075 in rat isolated aorta: relationship to functional effects of openers and blockers von QUAST, U, BRAY, K. M, ANDRES, H, MANLEY, P. W, BAUMLIN, Y, DOSOGNE, J

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Comparison of nilotinib and imatinib inhibition of FMS receptor signaling, macrophage production and osteoclastogenesis von Brownlow, N, Russell, A E, Saravanapavan, H, Wiesmann, M, Murray, J M, Manley, P W, Dibb, N J

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Structure-activity studies of potassium channel opening in pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas von Manley, Paul W, Quast, Ulrich

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Synthesis of and radioligand binding studies with a tritiated pinacidil analog: receptor interactions of structurally different classes of potassium channel openers and blockers von Manley, Paul W, Quast, Ulrich, Andres, Hendrik, Bray, Katharine

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Egyptian ‘Funerary Cones’ from El-Moghraqa, Gaza von Steel, L, Manley, W P, Clarke, J, Sadeq, M

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In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants von O'HARE, Thomas, WALTERS, Denise K, DRUKER, Brian J, STOFFREGEN, Eric P, TAIPING JIA, MANLEY, Paul W, MESTAN, Jürgen, COWAN-JACOB, Sandra W, LEE, Francis Y, HEINRICH, Michael C, DEININGER, Michael W. N

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The Crystal Structure of a c-Src Complex in an Active Conformation Suggests Possible Steps in c-Src Activation von Cowan-Jacob, Sandra W., Fendrich, Gabriele, Manley, Paul W., Jahnke, Wolfgang, Fabbro, Doriano, Liebetanz, Janis, Meyer, Thomas

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PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation o... von Gleixner, Karoline V., Mayerhofer, Matthias, Aichberger, Karl J., Derdak, Sophia, Sonneck, Karoline, Böhm, Alexandra, Gruze, Alexander, Samorapoompichit, Puchit, Manley, Paul W., Fabbro, Doriano, Pickl, Winfried F., Sillaber, Christian, Valent, Peter

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Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog von Boggon, Titus J., Li, Yiqun, Manley, Paul W., Eck, Michael J.

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Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia von Manley, Paul William, Cowan-Jacob, Sandra W., Mestan, Jürgen

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AMN107, a Novel Aminopyrimidine Inhibitor of Bcr-Abl, Has In vitro Activity against Imatinib-Resistant Chronic Myeloid Leukemia von GOLEMOVIC, Mirna, VERSTOVSEK, Srdan, ARLINGHAUS, Ralph B, TONG SUN, KANTARJIAN, Hagop, BERAN, Miloslav, GILES, Francis, CORTES, Jorge, MANSHOURI, Taghi, MANLEY, Paul W, MESTAN, Jürgen, DUGAN, Margaret, ALLAND, Leila, GRIFFIN, James D

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Protein kinases as targets for anticancer agents: from inhibitors to useful drugs von Fabbro, Doriano, Ruetz, Stephan, Buchdunger, Elisabeth, Cowan-Jacob, Sandra W, Fendrich, Gabriele, Liebetanz, Janis, Mestan, Jürgen, O'Reilly, Terence, Traxler, Peter, Chaudhuri, Bhabatosh, Fretz, Heinz, Zimmermann, Jürg, Meyer, Thomas, Caravatti, Giorgio, Furet, Pascal, Manley, Paul W

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