A general approach to site-specific antibody drug conjugates von Tian, Feng, Lu, Yingchun, Manibusan, Anthony, Sellers, Aaron, Tran, Hon, Sun, Ying, Phuong, Trung, Barnett, Richard, Hehli, Brad, Song, Frank, DeGuzman, Michael J., Ensari, Semsi, Pinkstaff, Jason K., Sullivan, Lorraine M., Biroc, Sandra L., Ho Cho, Schultz, Peter G., DiJoseph, John, Dougher, Maureen, Ma, Dangshe, Dushin, Russell, Leal, Mauricio, Tchistiakova, Lioudmila, Feyfant, Eric, Gerber, Hans-Peter, Sapra, Puja

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Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates von Kern, Jeffrey C, Cancilla, Mark, Dooney, Deborah, Kwasnjuk, Kristen, Zhang, Rena, Beaumont, Maribel, Figueroa, Isabel, Hsieh, SuChun, Liang, Linda, Tomazela, Daniela, Zhang, Jeffrey, Brandish, Philip E, Palmieri, Anthony, Stivers, Peter, Cheng, Mangeng, Feng, Guo, Geda, Prasanthi, Shah, Sanjiv, Beck, Andrew, Bresson, Damien, Firdos, Juhi, Gately, Dennis, Knudsen, Nick, Manibusan, Anthony, Schultz, Peter G, Sun, Ying, Garbaccio, Robert M

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In vitro and in vivo evaluation of cysteine and site specific conjugated herceptin antibody-drug conjugates von Jackson, Dowdy, Atkinson, John, Guevara, Claudia I, Zhang, Chunying, Kery, Vladimir, Moon, Sung-Ju, Virata, Cyrus, Yang, Peng, Lowe, Christine, Pinkstaff, Jason, Cho, Ho, Knudsen, Nick, Manibusan, Anthony, Tian, Feng, Sun, Ying, Lu, Yingchun, Sellers, Aaron, Jia, Xiao-Chi, Joseph, Ingrid, Anand, Banmeet, Morrison, Kendall, Pereira, Daniel S, Stover, David

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FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents von MU, James, PINKSTAFF, Jason, WU, Margaret, NORMAN, Thea C, RODRIGUEZ, Carlos G, KIMMEL, Bruce, METZGER, Joseph M, MANIBUSAN, Anthony, LEE, Darin, ZALLER, Dennis M, ZHANG, Bei B, DIMARCHI, Richard D, ZHIHUA LI, BERGER, Joel P, AXELROD, Douglas W, SKIDMORE, Lillian, NINA LI, MYLER, Heather, DALLAS-YANG, Qing, PUTNAM, Anna-Maria, JUN YAO, BUSSELL, Stuart

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A CXCR4-Targeted Site-Specific Antibody-Drug Conjugate von Kularatne, Sumith A., Deshmukh, Vishal, Ma, Jennifer, Tardif, Virginie, Lim, Reyna K. V., Pugh, Holly M., Sun, Ying, Manibusan, Anthony, Sellers, Aaron J., Barnett, Richard S., Srinagesh, Shailaja, Forsyth, Jane S., Hassenpflug, Wolf, Tian, Feng, Javahishvili, Tsotne, Felding-Habermann, Brunhilde, Lawson, Brian R., Kazane, Stephanie A., Schultz, Peter G.

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Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection von Beaumont, Maribel, Tomazela, Daniela, Hodges, Douglas, Ermakov, Grigori, Hsieh, Edward, Figueroa, Isabel, So, On-Yee, Song, Yaoli, Ma, Huiping, Antonenko, Svetlana, Mengesha, Wondwessen, Zhang, Yi Wei, Zhang, Shuli, Hseih, SuChun, Ayanoglu, Gulesi, Du, Xiaoyan, Rimmer, Eric, Judo, Michael, Vives, Franklin, Yearley, Jennifer H., Moon, Christina, Manibusan, Anthony, Knudsen, Nick, Beck, Andy, Bresson, Damien, Gately, Dennis, Neupane, Divas, Escandón, Enrique

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Abstract 480: Molecular mechanism of action of photoimmunotherapy with antibody-IR700 dye conjugates von Heim, Roger, Makings, Lew, Wiemann, Torsten, Manibusan, Anthony, Garcia-Guzman, Miguel

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Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCs von Kern, Jeffrey C., Dooney, Deborah, Zhang, Rena, Liang, Linda, Brandish, Philip E., Cheng, Mangeng, Feng, Guo, Beck, Andrew, Bresson, Damien, Firdos, Juhi, Gately, Dennis, Knudsen, Nick, Manibusan, Anthony, Sun, Ying, Garbaccio, Robert M.

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Development of Anti-CD74 Antibody–Drug Conjugates to Target Glucocorticoids to Immune Cells von Brandish, Philip E, Palmieri, Anthony, Antonenko, Svetlana, Beaumont, Maribel, Benso, Lia, Cancilla, Mark, Cheng, Mangeng, Fayadat-Dilman, Laurence, Feng, Guo, Figueroa, Isabel, Firdos, Juhi, Garbaccio, Robert, Garvin-Queen, Laura, Gately, Dennis, Geda, Prasanthi, Haines, Christopher, Hseih, SuChun, Hodges, Douglas, Kern, Jeffrey, Knudsen, Nickolas, Kwasnjuk, Kristen, Liang, Linda, Ma, Huiping, Manibusan, Anthony, Miller, Paul L, Moy, Lily Y, Qu, Yujie, Shah, Sanjiv, Shin, John S, Stivers, Peter, Sun, Ying, Tomazela, Daniela, Woo, Hyun Chong, Zaller, Dennis, Zhang, Shuli, Zhang, Yiwei, Zielstorff, Mark

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Comparison of bioanalytical methods for the quantitation of PEGylated human insulin von de Dios, Kristine, Manibusan, Anthony, Marsden, Robin, Pinkstaff, Jason

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Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice von Camacho, Raul C., Zafian, Peter T., Achanfuo-Yeboah, Joana, Manibusan, Anthony, Berger, Joel P.

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Role of tRNA Orthogonality in an Expanded Genetic Code von Javahishvili, Tsotne, Manibusan, Anthony, Srinagesh, Shaila, Lee, Darin, Ensari, Semsi, Shimazu, Mark, Schultz, Peter G

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Recruiting Cytotoxic T Cells to Folate-Receptor-Positive Cancer Cells von Kularatne, Sumith A., Deshmukh, Vishal, Gymnopoulos, Marco, Biroc, Sandra L., Xia, Jinming, Srinagesh, Shailaja, Sun, Ying, Zou, Ning, Shimazu, Mark, Pinkstaff, Jason, Ensari, Semsi, Knudsen, Nick, Manibusan, Anthony, Axup, Jun Y., Kim, Chan Hyuk, Smider, Vaughn V., Javahishvili, Tsotne, Schultz, Peter G.

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Abstract LB-222: Optimization and preclinical characterization of highly potent and stable anti-CD70 ADCs for the potential treatment of CD70 positive cancers von Skidmore, Lillian, Cox, Kari, Kirtley, Jessica, Le, Tiep, Firdos, Juhi, Manibusan, Anthony, Fang, Shiao-Yan, Beck, Andy, Bhowmik, Shiva, Knudsen, Nick, Wang, Jianing, Sun, Ying, Ayala, Armando, Powell, Alyssa, Wahl, Alan, Tian, Feng, Humphreys, Robin

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Abstract 668: Folate conjugated site-specifically to anti-human-CD3-Fab is efficacious in mouse models of ovarian cancer von Biroc, Sandra L., Gymnopoulos, Marco, Srinagesh, Shailaja, Hayes, Brad, Knudsen, Nick, Manibusan, Anthony, Pinkstaff, Jason, Buss, Tim, Cox, Kari, Marsden, Robin, Skidmore, Lillian, Xia, Jinming, Sun, Ying, Zou, Ning, Javahishvili, Tsotne

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Phthalocyanine dye conjugate compositions von SHAHROKH, Zahra, MANIBUSAN, Anthony

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Folate Receptor–Targeted T cells for Cancer Immunotherapy von Kularatne, Sumith A., Deshmukh, Vishal, Gymnopoulos, Marco, Biroc, Sandra L., Xia, Jinming, Srinagesh, Shaila, Sun, Ying, Zou, Ning, Shimazu, Mark, Pinkstaff, Jason, Ensari, Semsi, Knudsen, Nick, Manibusan, Anthony, Axup, Jun, Kim, Chanhyuk, Smider, Vaughn, Javahishvili, Tsotne, Schultz, Peter G.

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Recruiting Cytotoxic TCells to Folate-Receptor-Positive Cancer Cells von Kularatne, Sumith A, Deshmukh, Vishal, Gymnopoulos, Marco, Biroc, Sandra L, Xia, Jinming, Srinagesh, Shailaja, Sun, Ying, Zou, Ning, Shimazu, Mark, Pinkstaff, Jason, Ensari, Semsi, Knudsen, Nick, Manibusan, Anthony, Axup, Jun Y, Kim, Chan Hyuk, Smider, Vaughn V, Javahishvili, Tsotne, Schultz, Peter G

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Abstract 5691: Novel site-specific antibody drug conjugates based on novel amino acid incorporation technology have improved pharmaceutical properties over conventional antibody dr... von Sapra, Puja Sapra, Tchistiakova, Lioudmila, Dushin, Russell, Leal, Mauricio, DiJoseph, John, Veneziale, Robert, Feyfant, Eric, Gerber, HansPeter, Sun, Ying, Manibusan, Anthony, Lu, Yingchun, Sellers, Aaron, Phuong, Trung, DeGuzman, Michael, Ensari, Semsi, Barnett, Barney, Cho, Ho, Tian, Feng

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PHTHALOCYANINE DYE CONJUGATE COMPOSITIONS von MANIBUSAN, ANTHONY

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