Tau Blocks Traffic of Organelles, Neurofilaments, and APP Vesicles in Neurons and Enhances Oxidative Stress von Stamer, K., Vogel, R., Thies, E., Mandelkow, E., E.-M. Mandelkow

Volltext

Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses von Mandelkow, E.-M., Stamer, K., Vogel, R., Thies, E., Mandelkow, E.

Volltext

Anthraquinones Inhibit Tau Aggregation and Dissolve Alzheimer's Paired Helical Filaments in Vitro and in Cells von Pickhardt, Marcus, Gazova, Zuzana, von Bergen, Martin, Khlistunova, Inna, Wang, Yipeng, Hascher, Antje, Mandelkow, Eva-Maria, Biernat, Jacek, Mandelkow, Eckhard

Volltext

Tau aggregation is driven by a transition from random coil to beta sheet structure von von Bergen, Martin, Barghorn, Stefan, Biernat, Jacek, Mandelkow, Eva-Maria, Mandelkow, Eckhard

Volltext

Mutations of Tau Protein in Frontotemporal Dementia Promote Aggregation of Paired Helical Filaments by Enhancing Local β-Structure von von Bergen, Martin, Barghorn, Stefan, Li, Li, Marx, Alexander, Biernat, Jacek, Mandelkow, Eva-Maria, Mandelkow, Eckhard

Volltext

Tau in Alzheimer's disease von Mandelkow, Eva-Maria, Mandelkow, Eckhard

Volltext

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure von von Bergen, M, Friedhoff, P, Biernat, J, Heberle, J, Mandelkow, E M, Mandelkow, E

Volltext

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease von AUGUSTINACK, Jean C, SCHNEIDER, Anja, MANDELKOW, Eva-Maria, HYMAN, Bradley T

Volltext

Structure, Microtubule Interactions, and Paired Helical Filament Aggregation by Tau Mutants of Frontotemporal Dementias von Barghorn, S, Zheng-Fischhöfer, Q, Ackmann, M, Biernat, J, von Bergen, M, Mandelkow, E.-M, Mandelkow, E

Volltext

Overexpression of Tau Protein Inhibits Kinesin-Dependent Trafficking of Vesicles, Mitochondria, and Endoplasmic Reticulum: Implications for Alzheimer's Disease von Ebneth, A., Godemann, R., Stamer, K., Illenberger, S., Trinczek, B., E.-M. Mandelkow, Mandelkow, E.

Volltext

Phosphorylation that Detaches Tau Protein from Microtubules (Ser262, Ser214) Also Protects It against Aggregation into Alzheimer Paired Helical Filaments von Schneider, A, Biernat, J, von Bergen, M, Mandelkow, E, Mandelkow, E.-M

Volltext

MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1 von Timm, Thomas, Li, Xiao-Yu, Biernat, Jacek, Jiao, Jian, Mandelkow, Eckhard, Vandekerckhove, Joel, Mandelkow, Eva-Maria

Volltext

Single-molecule investigation of the interference between kinesin, tau and MAP2c von Seitz, Arne, Kojima, Hiroaki, Oiwa, Kazuhiro, Mandelkow, Eva-Maria, Song, Young-Hwa, Mandelkow, Eckhard

Volltext

MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption von Drewes, Gerard, Ebneth, Andreas, Preuss, Ute, Mandelkow, Eva-Maria, Mandelkow, Eckhard

Volltext

Rapid Assembly of Alzheimer-like Paired Helical Filaments from Microtubule-Associated Protein Tau Monitored by Fluorescence in Solution von Friedhoff, Peter, Schneider, Anja, Mandelkow, Eva-Maria, Mandelkow, Eckhard

Volltext

Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity von Biernat, Jacek, Wu, Yong-Zhong, Timm, Thomas, Zheng-Fischhöfer, Qingyi, Mandelkow, Eckhard, Meijer, Laurent, Mandelkow, Eva-Maria

Volltext

Kinesin motors and disease von Mandelkow, Eckhard, Mandelkow, Eva-Maria

Volltext

Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles von Trinczek, B, Ebneth, A, Mandelkow, E M, Mandelkow, E

Volltext

Engineered antibodies: new possibilities for brain PET? von Sehlin, Dag, Syvänen, Stina

Volltext

A Nucleated Assembly Mechanism of Alzheimer Paired Helical Filaments von Friedhoff, P., Von Bergen, M., E.-M. Mandelkow, Davies, P., Mandelkow, E.

Volltext