Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress von Ghosh, Rajarshi, Wang, Likun, Wang, Eric S., Perera, B. Gayani K., Igbaria, Aeid, Morita, Shuhei, Prado, Kris, Thamsen, Maike, Caswell, Deborah, Macias, Hector, Weiberth, Kurt F., Gliedt, Micah J., Alavi, Marcel V., Hari, Sanjay B., Mitra, Arinjay K., Bhhatarai, Barun, Schürer, Stephan C., Snapp, Erik L., Gould, Douglas B., German, Michael S., Backes, Bradley J., Maly, Dustin J., Oakes, Scott A., Papa, Feroz R.

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Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs von Rose, John C., Popp, Nicholas A., Richardson, Christopher D., Stephany, Jason J., Mathieu, Julie, Wei, Cindy T., Corn, Jacob E., Maly, Dustin J., Fowler, Douglas M.

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A chemically controlled Cas9 switch enables temporal modulation of diverse effectors von Wei, Cindy T., Popp, Nicholas A., Peleg, Omri, Powell, Rachel L., Borenstein, Elhanan, Maly, Dustin J., Fowler, Douglas M.

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Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung von Thamsen, Maike, Ghosh, Rajarshi, Auyeung, Vincent C, Brumwell, Alexis, Chapman, Harold A, Backes, Bradley J, Perara, Gayani, Maly, Dustin J, Sheppard, Dean, Papa, Feroz R

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Druggable sensors of the unfolded protein response von Maly, Dustin J, Papa, Feroz R

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Targeting Dynamic ATP-Binding Site Features Allows Discrimination between Highly Homologous Protein Kinases von Chakraborty, Sujata, Inukai, Takayuki, Fang, Linglan, Golkowski, Martin, Maly, Dustin J

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Bumped Kinase Inhibitor 1294 Treats Established Toxoplasma gondii Infection von STONE DOGGETT, J, OJO, Kayode K, FAN, Erkang, MALY, Dustin J, VAN VOORHIS, Wesley C

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Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection von Arnold, Samuel L. M., Choi, Ryan, Hulverson, Matthew A., Schaefer, Deborah A., Vinayak, Sumiti, Vidadala, Rama S. R., McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Barrett, Lynn K., Ojo, Kayode K., Fan, Erkang, Maly, Dustin J., Riggs, Michael W., Striepen, Boris, Van Voorhis, Wesley C.

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Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis von Schaefer, Deborah A., Betzer, Dana P., Smith, Kylie D., Millman, Zachary G., Michalski, Hannah C., Menchaca, Sarah E., Zambriski, Jennifer A., Ojo, Kayode K., Hulverson, Matthew A., Arnold, Samuel L. M., Rivas, Kasey L., Vidadala, Rama S. R., Huang, Wenlin, Barrett, Lynn K., Maly, Dustin J., Fan, Erkang, Van Voorhis, Wesley C., Riggs, Michael W.

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Kinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors von Golkowski, Martin, Vidadala, Rama Subba Rao, Lombard, Chloe K, Suh, Hyong Won, Maly, Dustin J, Ong, Shao-En

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Subcellular drug targeting illuminates local kinase action von Bucko, Paula J, Lombard, Chloe K, Rathbun, Lindsay, Garcia, Irvin, Bhat, Akansha, Wordeman, Linda, Smith, F Donelson, Maly, Dustin J, Hehnly, Heidi, Scott, John D

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A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation von Ojo, Kayode K., Eastman, Richard T., Vidadala, RamaSubbaRao, Zhang, Zhongsheng, Rivas, Kasey L., Choi, Ryan, Lutz, Justin D., Reid, Molly C., Fox, Anna M. W., Hulverson, Matthew A., Kennedy, Mark, Isoherranen, Nina, Kim, Laura M., Comess, Kenneth M., Kempf, Dale J., Verlinde, Christophe L. M. J., Su, Xin-zhuan, Kappe, Stefan H. I., Maly, Dustin J., Fan, Erkang, Van Voorhis, Wesley C.

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Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds von Crowther, Gregory J, Hillesland, Heidi K, Keyloun, Katelyn R, Reid, Molly C, Lafuente-Monasterio, Maria Jose, Ghidelli-Disse, Sonja, Leonard, Stephen E, He, Panqing, Jones, Jackson C, Krahn, Mallory M, Mo, Jack S, Dasari, Kartheek S, Fox, Anna M W, Boesche, Markus, El Bakkouri, Majida, Rivas, Kasey L, Leroy, Didier, Hui, Raymond, Drewes, Gerard, Maly, Dustin J, Van Voorhis, Wesley C, Ojo, Kayode K

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Biochemical Mechanisms of Resistance to Small-Molecule Protein Kinase Inhibitors von Krishnamurty, Ratika, Maly, Dustin J

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Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G von Bansal, Abhisheka, Ojo, Kayode K, Mu, Jianbing, Maly, Dustin J, Van Voorhis, Wesley C, Miller, Louis H

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Druggable sensors of the unfolded protein response von Maly, Dustin J, Papa, Feroz R

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Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors von Ojo, Kayode K, Pfander, Claudia, Mueller, Natascha R, Burstroem, Charlotte, Larson, Eric T, Bryan, Cassie M, Fox, Anna M W, Reid, Molly C, Johnson, Steven M, Murphy, Ryan C, Kennedy, Mark, Mann, Henning, Leibly, David J, Hewitt, Stephen N, Verlinde, Christophe L M J, Kappe, Stefan, Merritt, Ethan A, Maly, Dustin J, Billker, Oliver, Van Voorhis, Wesley C

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Active site profiling reveals coupling between domains in SRC-family kinases von Krishnamurty, Ratika, Brigham, Jennifer L, Leonard, Stephen E, Ranjitkar, Pratistha, Larson, Eric T, Dale, Edward J, Merritt, Ethan A, Maly, Dustin J

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Peptide Microarrays for the Determination of Protease Substrate Specificity von Salisbury, Cleo M, Maly, Dustin J, Ellman, Jonathan A

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The Right Tool for the Job: A Chemical and Genetic Toolkit for Interrogating DCLK1 Function von Fang, Linglan, Maly, Dustin J.

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