Engineering IL-2 for immunotherapy of autoimmunity and cancer von Hernandez, Rosmely, Põder, Janika, LaPorte, Kathryn M., Malek, Thomas R.

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Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity von Malek, Thomas R., Castro, Iris

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The biology of interleukin-2 von Malek, Thomas R

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Regulatory T cells in the treatment of disease von Sharabi, Amir, Tsokos, Maria G., Ding, Ying, Malek, Thomas R., Klatzmann, David, Tsokos, George C.

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The importance of regulatory T-cell heterogeneity in maintaining self-tolerance von Yuan, Xiaomei, Cheng, Guoyan, Malek, Thomas R.

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Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes von Yu, Aixin, Snowhite, Isaac, Vendrame, Francesco, Rosenzwajg, Michelle, Klatzmann, David, Pugliese, Alberto, Malek, Thomas R

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Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity von Berezhnoy, Alexey, Castro, Iris, Levay, Agata, Malek, Thomas R, Gilboa, Eli

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Cytokine Signaling in the Development and Homeostasis of Regulatory T cells von Toomer, Kevin H, Malek, Thomas R

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Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer von Shouse, Acacia N., LaPorte, Kathryn M., Malek, Thomas R.

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Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells von Toomer, Kevin H., Lui, Jen Bon, Altman, Norman H., Ban, Yuguang, Chen, Xi, Malek, Thomas R.

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T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells von Cheng, Guoyan, Yu, Aixin, Malek, Thomas R.

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A Low Interleukin-2 Receptor Signaling Threshold Supports the Development and Homeostasis of T Regulatory Cells von Yu, Aixin, Zhu, Linjian, Altman, Norman H., Malek, Thomas R.

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Fueling Cancer Vaccines to Improve T Cell-Mediated Antitumor Immunity von Hernandez, Rosmely, Malek, Thomas R

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The main function of IL-2 is to promote the development of T regulatory cells von Malek, Thomas R.

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IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development von Cheng, Guoyan, Yu, Aixin, Dee, Michael J, Malek, Thomas R

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Tolerance, not immunity, crucially depends on IL-2 von Malek, Thomas R, Bayer, Allison L

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Cytokine-Dependent Blimp-1 Expression in Activated T Cells Inhibits IL-2 Production von Gong, Dapeng, Malek, Thomas R

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CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells von Ding, Ying, Yu, Aixin, Tsokos, George C, Malek, Thomas R

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Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients von Rosenzwajg, Michelle, Churlaud, Guillaume, Mallone, Roberto, Six, Adrien, Dérian, Nicolas, Chaara, Wahiba, Lorenzon, Roberta, Long, S. Alice, Buckner, Jane H, Afonso, Georgia, Pham, Hang-Phuong, Hartemann, Agnès, Yu, Aixin, Pugliese, Alberto, Malek, Thomas R, Klatzmann, David

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IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells von Ward, Natasha C, Yu, Aixin, Moro, Alejandro, Ban, Yuguang, Chen, Xi, Hsiung, Sunnie, Keegan, James, Arbanas, Jaren M, Loubeau, Martine, Thankappan, Anil, Yamniuk, Aaron P, Davis, Jonathan H, Struthers, Mary, Malek, Thomas R

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