NRF2 Activation in Cancer: From DNA to Protein von Cloer, Erica W, Goldfarb, Dennis, Schrank, Travis P, Weissman, Bernard E, Major, Michael B

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Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus von Fu, Junsheng, Xiong, Zhaohui, Huang, Caizhi, Li, Jing, Yang, Wenjun, Han, Yuning, Paiboonrungruan, Chorlada, Major, Michael B., Chen, Ke-Neng, Kang, Xiaozheng, Chen, Xiaoxin

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ARID1A loss is associated with increased NRF2 signaling in human head and neck squamous cell carcinomas von Nguyen, Vinh, Schrank, Travis P, Major, Michael B, Weissman, Bernard E

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The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase von Onyenwoke, Rob U, Sexton, Jonathan Z, Yan, Feng, Díaz, María Cristina Huertas, Forsberg, Lawrence J, Major, Michael B, Brenman, Jay E

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Glycosylation of KEAP1 links nutrient sensing to redox stress signaling von Chen, Po‐Han, Smith, Timothy J, Wu, Jianli, Siesser, Priscila F, Bisnett, Brittany J, Khan, Farhan, Hogue, Maxwell, Soderblom, Erik, Tang, Flora, Marks, Jeffrey R, Major, Michael B, Swarts, Benjamin M, Boyce, Michael, Chi, Jen‐Tsan

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BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization von Orvis, Tess, Hepperla, Austin, Walter, Vonn, Song, Shujie, Simon, Jeremy, Parker, Joel, Wilkerson, Matthew D, Desai, Nisarg, Major, Michael B, Hayes, D Neil, Davis, Ian J, Weissman, Bernard

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TCAF1 promotes TRPV2-mediated Ca2+ release in response to cytosolic DNA to protect stressed replication forks von Kong, Lingzhen, Cheng, Chen, Cheruiyot, Abigael, Yuan, Jiayi, Yang, Yichan, Hwang, Sydney, Foust, Daniel, Tsao, Ning, Wilkerson, Emily, Mosammaparast, Nima, Major, Michael B., Piston, David W., Li, Shan, You, Zhongsheng

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Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency von Chen, Jianfeng, Su, Siyuan, Pickar-Oliver, Adrian, Chiarella, Anna M, Hahn, Quentin, Goldfarb, Dennis, Cloer, Erica W, Small, George W, Sivashankar, Smaran, Ramsden, Dale A, Major, Michael B, Hathaway, Nathaniel A, Gersbach, Charles A, Liu, Pengda

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Author Correction: A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis von Gao, Yanzhe, Mutter-Rottmayer, Elizabeth, Greenwalt, Alicia M., Goldfarb, Dennis, Yan, Feng, Yang, Yang, Martinez-Chacin, Raquel C., Pearce, Kenneth H., Tateishi, Satoshi, Major, Michael B., Vaziri, Cyrus

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A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models von Puray-Chavez, Maritza, Eschbach, Jenna E., Xia, Ming, LaPak, Kyle M., Zhou, Qianzi, Jasuja, Ria, Pan, Jiehong, Xu, Jian, Zhou, Zixiang, Mohammed, Shawn, Wang, Qibo, Lawson, Dana Q., Djokic, Sanja, Hou, Gaopeng, Ding, Siyuan, Brody, Steven L., Major, Michael B., Goldfarb, Dennis, Kutluay, Sebla B.

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The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells von Gao, Yanzhe, Kardos, Jordan, Yang, Yang, Tamir, Tigist Y., Mutter-Rottmayer, Elizabeth, Weissman, Bernard, Major, Michael B., Kim, William Y., Vaziri, Cyrus

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Distinct Wnt signaling pathways have opposing roles in appendage regeneration von Stoick-Cooper, Cristi L, Weidinger, Gilbert, Riehle, Kimberly J, Hubbert, Charlotte, Major, Michael B, Fausto, Nelson, Moon, Randall T

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WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling von James, Richard G, Davidson, Kathryn C, Bosch, Katherine A, Biechele, Travis L, Robin, Nicholas C, Taylor, Russell J, Major, Michael B, Camp, Nathan D, Fowler, Kerry, Martins, Timothy J, Moon, Randall T

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Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate von Mulvaney, Kathleen M., Matson, Jacob P., Siesser, Priscila F., Tamir, Tigist Y., Goldfarb, Dennis, Jacobs, Timothy M., Cloer, Erica W., Harrison, Joseph S., Vaziri, Cyrus, Cook, Jeanette G., Major, Michael B.

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USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds von Madan, Babita, Walker, Matthew P., Young, Robert, Quick, Laura, Orgel, Kelly A., Ryan, Meagan, Gupta, Priti, Henrich, Ian C., Ferrer, Marc, Marine, Shane, Roberts, Brian S., Arthur, William T., Berndt, Jason D., Oliveira, Andre M., Moon, Randall T., Virshup, David M., Chou, Margaret M., Major, Michael B.

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Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1 von Harrison, Joseph S, Cornett, Evan M, Goldfarb, Dennis, DaRosa, Paul A, Li, Zimeng M, Yan, Feng, Dickson, Bradley M, Guo, Angela H, Cantu, Daniel V, Kaustov, Lilia, Brown, Peter J, Arrowsmith, Cheryl H, Erie, Dorothy A, Major, Michael B, Klevit, Rachel E, Krajewski, Krzysztof, Kuhlman, Brian, Strahl, Brian D, Rothbart, Scott B

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A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis von Gao, Yanzhe, Mutter-Rottmayer, Elizabeth, Greenwalt, Alicia M., Goldfarb, Dennis, Yan, Feng, Yang, Yang, Martinez-Chacin, Raquel C., Pearce, Kenneth H., Tateishi, Satoshi, Major, Michael B., Vaziri, Cyrus

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Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein von Camp, Nathan D., James, Richard G., Dawson, David W., Yan, Feng, Davison, James M., Houck, Scott A., Tang, Xiaobo, Zheng, Ning, Major, Michael B., Moon, Randall T.

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Ginger Compound [6]-Shogaol and Its Cysteine-Conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo von Chen, Huadong, Fu, Junsheng, Chen, Hao, Hu, Yuhui, Soroka, Dominique N, Prigge, Justin R, Schmidt, Edward E, Yan, Feng, Major, Michael B, Chen, Xiaoxin, Sang, Shengmin

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Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability von Stratford, Jeran K, Yan, Feng, Hill, Rebecca A, Major, Michael B, Graves, Lee M, Der, Channing J, Yeh, Jen Jen

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