Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo von Yanamandra, Kiran, Kfoury, Najla, Jiang, Hong, Mahan, Thomas E., Ma, Shengmei, Maloney, Susan E., Wozniak, David F., Diamond, Marc I., Holtzman, David M.

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The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans von Holth, Jerrah K, Fritschi, Sarah K, Wang, Chanung, Pedersen, Nigel P, Cirrito, John R, Mahan, Thomas E, Finn, Mary Beth, Manis, Melissa, Geerling, Joel C, Fuller, Patrick M, Lucey, Brendan P, Holtzman, David M

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TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques von Wang, Yaming, Ulland, Tyler K, Ulrich, Jason D, Song, Wilbur, Tzaferis, John A, Hole, Justin T, Yuan, Peng, Mahan, Thomas E, Shi, Yang, Gilfillan, Susan, Cella, Marina, Grutzendler, Jaime, DeMattos, Ronald B, Cirrito, John R, Holtzman, David M, Colonna, Marco

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Proteopathic tau seeding predicts tauopathy in vivo von Holmes, Brandon B, Furman, Jennifer L, Mahan, Thomas E, Yamasaki, Tritia R, Mirbaha, Hilda, Eades, William C, Belaygorod, Larisa, Cairns, Nigel J, Holtzman, David M, Diamond, Marc I

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Neuronal activity regulates extracellular tau in vivo von Yamada, Kaoru, Holth, Jerrah K, Liao, Fan, Stewart, Floy R, Mahan, Thomas E, Jiang, Hong, Cirrito, John R, Patel, Tirth K, Hochgräfe, Katja, Mandelkow, Eva-Maria, Holtzman, David M

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ApoE facilitates the microglial response to amyloid plaque pathology von Ulrich, Jason D, Ulland, Tyler K, Mahan, Thomas E, Nyström, Sofie, Nilsson, K Peter, Song, Wilbur M, Zhou, Yingyue, Reinartz, Mariska, Choi, Seulah, Jiang, Hong, Stewart, Floy R, Anderson, Elise, Wang, Yaming, Colonna, Marco, Holtzman, David M

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Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis von Mahan, Thomas E, Wang, Chao, Bao, Xin, Choudhury, Ankit, Ulrich, Jason D, Holtzman, David M

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Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease von Roh, Jee Hoon, Jiang, Hong, Finn, Mary Beth, Stewart, Floy R, Mahan, Thomas E, Cirrito, John R, Heda, Ashish, Snider, B Joy, Li, Mingjie, Yanagisawa, Masashi, de Lecea, Luis, Holtzman, David M

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High‐affinity interactions and signal transduction between Aβ oligomers and TREM2 von Lessard, Christian B, Malnik, Samuel L, Zhou, Yingyue, Ladd, Thomas B, Cruz, Pedro E, Ran, Yong, Mahan, Thomas E, Chakrabaty, Paramita, Holtzman, David M, Ulrich, Jason D, Colonna, Marco, Golde, Todd E

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Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis von Huynh, Tien-Phat V., Liao, Fan, Francis, Caroline M., Robinson, Grace O., Serrano, Javier Remolina, Jiang, Hong, Roh, Joseph, Finn, Mary Beth, Sullivan, Patrick M., Esparza, Thomas J., Stewart, Floy R., Mahan, Thomas E., Ulrich, Jason D., Cole, Tracy, Holtzman, David M.

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C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation von Lall, Deepti, Lorenzini, Ileana, Mota, Thomas A., Bell, Shaughn, Mahan, Thomas E., Ulrich, Jason D., Davtyan, Hayk, Rexach, Jessica E., Muhammad, A.K.M. Ghulam, Shelest, Oksana, Landeros, Jesse, Vazquez, Michael, Kim, Junwon, Ghaffari, Layla, O’Rourke, Jacqueline Gire, Geschwind, Daniel H., Blurton-Jones, Mathew, Holtzman, David M., Sattler, Rita, Baloh, Robert H.

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Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model von Huynh, Tien-Phat V, Wang, Chao, Tran, Ainsley C, Tabor, G Travis, Mahan, Thomas E, Francis, Caroline M, Finn, Mary Beth, Spellman, Rebecca, Manis, Melissa, Tanzi, Rudolph E, Ulrich, Jason D, Holtzman, David M

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Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2 von Ulrich, Jason D, Finn, Mary Beth, Wang, Yaming, Shen, Alice, Mahan, Thomas E, Jiang, Hong, Stewart, Floy R, Piccio, Laura, Colonna, Marco, Holtzman, David M

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Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo von Macauley, Shannon L, Stanley, Molly, Caesar, Emily E, Yamada, Steven A, Raichle, Marcus E, Perez, Ronaldo, Mahan, Thomas E, Sutphen, Courtney L, Holtzman, David M

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In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis von Ulrich, Jason D, Burchett, Jack M, Restivo, Jessica L, Schuler, Dorothy R, Verghese, Philip B, Mahan, Thomas E, Landreth, Gary E, Castellano, Joseph M, Jiang, Hong, Cirrito, John R, Holtzman, David M

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Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis von Liao, Fan, Hori, Yukiko, Hudry, Eloise, Bauer, Adam Q, Jiang, Hong, Mahan, Thomas E, Lefton, Katheryn B, Zhang, Tony J, Dearborn, Joshua T, Kim, Jungsu, Culver, Joseph P, Betensky, Rebecca, Wozniak, David F, Hyman, Bradley T, Holtzman, David M

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Analysis of in vivo turnover of tau in a mouse model of tauopathy von Yamada, Kaoru, Patel, Tirth K, Hochgräfe, Katja, Mahan, Thomas E, Jiang, Hong, Stewart, Floy R, Mandelkow, Eva-Maria, Holtzman, David M

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Altered sleep and EEG power in the P301S Tau transgenic mouse model von Holth, Jerrah K., Mahan, Thomas E., Robinson, Grace O., Rocha, Andreia, Holtzman, David M.

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Anti‐tau antibody reduces insoluble tau and decreases brain atrophy von Yanamandra, Kiran, Jiang, Hong, Mahan, Thomas E., Maloney, Susan E., Wozniak, David F., Diamond, Marc I., Holtzman, David M.

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Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model von Liao, Fan, Jiang, Hong, Srivatsan, Subhashini, Xiao, Qingli, Lefton, Katheryn B, Yamada, Kaoru, Mahan, Thomas E, Lee, Jin-Moo, Shaw, Andrey S, Holtzman, David M

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