A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy von Ronan, Baptiste, Flamand, Odile, Vescovi, Lionel, Dureuil, Christine, Durand, Laurence, Fassy, Florence, Bachelot, Marie-France, Lamberton, Annabelle, Mathieu, Magali, Bertrand, Thomas, Marquette, Jean-Pierre, El-Ahmad, Youssef, Filoche-Romme, Bruno, Schio, Laurent, Garcia-Echeverria, Carlos, Goulaouic, Hélène, Pasquier, Benoit

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Structural insights into the bi-specific cross-over dual variable antibody architecture by cryo-EM von Fernandez-Martinez, David, Tully, Mark D., Leonard, Gordon, Mathieu, Magali, Kandiah, Eaazhisai

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Deciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold von Pruvost, Tiphanie, Mathieu, Magali, Dubois, Steven, Maillère, Bernard, Vigne, Emmanuelle, Nozach, Hervé

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Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule von Deng, Gejing, Shen, Junqing, Yin, Ming, McManus, Jessica, Mathieu, Magali, Gee, Patricia, He, Timothy, Shi, Chaomei, Bedel, Olivier, McLean, Larry R., Le-Strat, Frank, Zhang, Ying, Marquette, Jean-Pierre, Gao, Qiang, Zhang, Bailin, Rak, Alexey, Hoffmann, Dietmar, Rooney, Eamonn, Vassort, Aurelie, Englaro, Walter, Li, Yi, Patel, Vinod, Adrian, Francisco, Gross, Stefan, Wiederschain, Dmitri, Cheng, Hong, Licht, Stuart

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Automated harvesting and processing of protein crystals through laser photoablation von Zander, Ulrich, Hoffmann, Guillaume, Cornaciu, Irina, Marquette, Jean-Pierre, Papp, Gergely, Landret, Christophe, Seroul, Gaël, Sinoir, Jérémy, Röwer, Martin, Felisaz, Frank, Rodriguez-Puente, Sonia, Mariaule, Vincent, Murphy, Peter, Mathieu, Magali, Cipriani, Florent, Márquez, José Antonio

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Discovery of (2S)‑8-[(3R)‑3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro‑2H‑pyrimido[1,2‑a]pyrimidin-6-one: A Novel Potent and Selective Inhibitor... von Pasquier, Benoit, El-Ahmad, Youssef, Filoche-Rommé, Bruno, Dureuil, Christine, Fassy, Florence, Abecassis, Pierre-Yves, Mathieu, Magali, Bertrand, Thomas, Benard, Tsiala, Barrière, Cédric, El Batti, Samira, Letallec, Jean-Philippe, Sonnefraud, Véronique, Brollo, Maurice, Delbarre, Laurence, Loyau, Véronique, Pilorge, Fabienne, Bertin, Luc, Richepin, Patrick, Arigon, Jérôme, Labrosse, Jean-Robert, Clément, Jacques, Durand, Florence, Combet, Romain, Perraut, Pierre, Leroy, Vincent, Gay, Frédéric, Lefrançois, Dominique, Bretin, François, Marquette, Jean-Pierre, Michot, Nadine, Caron, Anne, Castell, Christelle, Schio, Laurent, McCort, Gary, Goulaouic, Hélène, Garcia-Echeverria, Carlos, Ronan, Baptiste

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Differential Water Thermodynamics Determine PI3K-Beta/Delta Selectivity for Solvent-Exposed Ligand Modifications von Robinson, Daniel, Bertrand, Thomas, Carry, Jean-Christophe, Halley, Frank, Karlsson, Andreas, Mathieu, Magali, Minoux, Hervé, Perrin, Marc-Antoine, Robert, Benoit, Schio, Laurent, Sherman, Woody

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An end-to-end automated platform process for high-throughput engineering of next-generation multi-specific antibody therapeutics von Furtmann, Norbert, Schneider, Marion, Spindler, Nadja, Steinmann, Bjoern, Li, Ziyu, Focken, Ingo, Meyer, Joachim, Dimova, Dilyana, Kroll, Katja, Leuschner, Wulf Dirk, Debeaumont, Audrey, Mathieu, Magali, Lange, Christian, Dittrich, Werner, Kruip, Jochen, Schmidt, Thorsten, Birkenfeld, Joerg

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Crystal Structure of the RNA-Dependent RNA Polymerase of Hepatitis C Virus von Bressanelli, Stéphane, Tomei, Licia, Roussel, Alain, Incitti, Ilario, Vitale, Rosa Letizia, Mathieu, Magali, De Francesco, Raffaele, Rey, Félix A.

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Abstract P-45: Structural Studies of Multispecific Antibody/Antigen Complexes by Cryo-EM von Fernandez-Martinez, David, Kandiah, Eaazhisai, Mathieu, Magali, Leonard, Gordon

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Dengue Virus Type 1 Nonstructural Glycoprotein NS1 Is Secreted from Mammalian Cells as a Soluble Hexamer in a Glycosylation-Dependent Fashion von Flamand, M, Megret, F, Mathieu, M, Lepault, J, Rey, F A, Deubel, V

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The Crystal Structures of Four Peptide Deformylases Bound to the Antibiotic Actinonin Reveal Two Distinct Types: A Platform for the Structure-based Design of Antibacterial Agents von Guilloteau, Jean-Pierre, Mathieu, Magali, Giglione, Carmela, Blanc, Véronique, Dupuy, Alain, Chevrier, Miline, Gil, Patricia, Famechon, Alain, Meinnel, Thierry, Mikol, Vincent

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Escherichia coli FolC Structure Reveals an Unexpected Dihydrofolate Binding Site Providing an Attractive Target for Anti-microbial Therapy von Mathieu, Magali, Debousker, Guy, Vincent, Sophie, Viviani, Fabrice, Bamas-Jacques, Nathalie, Mikol, Vincent

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1024 Non-tumour risk factors for cutaneous melanoma relapse von Autier, P, Aegerter, Mathieu Boniol, Magali Boniol, P, Saiag, P

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Alteration mapping on drill cores using a HySpex SWIR-320m hyperspectral camera: Application to the exploration of an unconformity-related uranium deposit (Saskatchewan, Canada) von Mathieu, Magali, Roy, Régis, Launeau, Patrick, Cathelineau, Michel, Quirt, David

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Complexation of Two Proteic Insect Inhibitors to the Active Site of Chymotrypsin Suggests Decoupled Roles for Binding and Selectivity von Roussel, Alain, Mathieu, Magali, Dobbs, Aaron, Luu, Bang, Cambillau, Christian, Kellenberger, Christine

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Structure of the Sec7 domain of the Arf exchange factor ARNO von Cherfils, Jacqueline, Ménétrey, Julie, Mathieu, Magali, Le Bras, Gérard, Robineau, Sylviane, Béraud-Dufour, Sophie, Antonny, Bruno, Chardin, Pierre

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Fast NMR Methods for Measuring in the Direct and/or Competition Mode the Dissociation Constants of Chemical Fragments Interacting with a Receptor von Dalvit, Claudio, Parent, Annick, Vallée, Francois, Mathieu, Magali, Rak, Alexey

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Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex von Ruedas, Rémi, Vuillemot, Rémi, Tubiana, Thibault, Winter, Jean-Marie, Pieri, Laura, Arteni, Ana-Andreea, Samson, Camille, Jonic, Slavica, Mathieu, Magali, Bressanelli, Stéphane

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Discovery of 6‑(2,4-Dichlorophenyl)-5-[4-[(3S)‑1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro‑7H‑benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Es... von El-Ahmad, Youssef, Tabart, Michel, Halley, Frank, Certal, Victor, Thompson, Fabienne, Filoche-Rommé, Bruno, Gruss-Leleu, Florence, Muller, Claire, Brollo, Maurice, Fabien, Laurence, Loyau, Véronique, Bertin, Luc, Richepin, Patrick, Pilorge, Fabienne, Desmazeau, Pascal, Girardet, Chrystelle, Beccari, Sylvie, Louboutin, Audrey, Lebourg, Gilles, Le-Roux, Jacques, Terrier, Corinne, Vallée, François, Steier, Valérie, Mathieu, Magali, Rak, Alexey, Abecassis, Pierre-Yves, Vicat, Pascale, Benard, Tsiala, Bouaboula, Monsif, Sun, Fangxian, Shomali, Maysoun, Hebert, Andrew, Levit, Mikhail, Cheng, Hong, Courjaud, Albane, Ginesty, Celine, Perrault, Christelle, Garcia-Echeverria, Carlos, McCort, Gary, Schio, Laurent

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