AKT crystal structure and AKT-specific inhibitors von Kumar, Chandra C, Madison, Vincent

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Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors von Fischmann, Thierry O, Smith, Catherine K, Mayhood, Todd W, Myers, Joseph E, Reichert, Paul, Mannarino, Anthony, Carr, Donna, Zhu, Hugh, Wong, Jesse, Yang, Rong-Sheng, Le, Hung V, Madison, Vincent S

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Three-Dimensional Models of Wild-Type and Mutated Forms of Cytochrome P450 14α-Sterol Demethylases from Aspergillus fumigatus and Candida albicans Provide Insights into Posaconazol... von Xiao, Li, Madison, Vincent, Chau, Andrew S, Loebenberg, David, Palermo, Robert E, McNicholas, Paul M

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Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM... von Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H, Kennedy, Matthew E, Beyer, Brian M, Senior, Mary M, Smith, Elizabeth M, Nechuta, Terry L, Madison, Vincent S, Czarniecki, Michael, McKittrick, Brian A, Stamford, Andrew W, Parker, Eric M, Hunter, John C, Greenlee, William J, Wyss, Daniel F

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Identification of Novel Cannabinoid CB1 Receptor Antagonists by Using Virtual Screening with a Pharmacophore Model von Wang, Hongwu, Duffy, Ruth A, Boykow, George C, Chackalamannil, Samuel, Madison, Vincent S

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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 1 von Dwyer, Michael P., Paruch, Kamil, Labroli, Marc, Alvarez, Carmen, Keertikar, Kerry M., Poker, Cory, Rossman, Randall, Fischmann, Thierry O., Duca, Jose S., Madison, Vincent, Parry, David, Davis, Nicole, Seghezzi, Wolfgang, Wiswell, Derek, Guzi, Timothy J.

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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 2 von Labroli, Marc, Paruch, Kamil, Dwyer, Michael P., Alvarez, Carmen, Keertikar, Kartik, Poker, Cory, Rossman, Randall, Duca, Jose S., Fischmann, Thierry O., Madison, Vincent, Parry, David, Davis, Nicole, Seghezzi, Wolfgang, Wiswell, Derek, Guzi, Timothy J.

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Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor von Deng, Yongqi, Shipps, Jr, Gerald W, Zhao, Lianyun, Siddiqui, M Arshad, Popovici-Muller, Janeta, Curran, Patrick J, Duca, Jose S, Hruza, Alan W, Fischmann, Thierry O, Madison, Vincent S, Zhang, Rumin, McNemar, Charles W, Mayhood, Todd W, Syto, Rosalinda, Annis, Allen, Kirschmeier, Paul, Lees, Emma M, Parry, David A, Windsor, William T

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The Active Site of a Zinc-Dependent Metalloproteinase Influences the Computed pKa of Ligands Coordinated to the Catalytic Zinc Ion von CROSS, Jason B., DUCA, José S., KAMINSKI, James J., MADISON, Vincent S.

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Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor von Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L, Venkatraman, Srikanth, Blackman, Melissa, Chen, Kevin X, Hendrata, Siska, Huang, Yuhua, Huelgas, Regina M, Nair, Latha, Padilla, Angela I, Pan, Weidong, Pike, Russell, Pinto, Patrick, Ruan, Sumei, Sannigrahi, Mousumi, Velazquez, Francisco, Vibulbhan, Bancha, Wu, Wanli, Yang, Weiying, Saksena, Anil K, Girijavallabhan, Viyyoor, Shih, Neng-Yang, Kong, Jianshe, Meng, Tao, Jin, Yan, Wong, Jesse, McNamara, Paul, Prongay, Andrew, Madison, Vincent, Piwinski, John J, Cheng, Kuo-Chi, Morrison, Richard, Malcolm, Bruce, Tong, Xiao, Ralston, Robert, Njoroge, F. George

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Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl... von Prongay, Andrew J, Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers, Joseph, Weber, Patricia C, Beyer, Brian M, Ingram, Richard, Hong, Zhi, Prosise, Winifred W, Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G, Saksena, Anil K, Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George, Madison, Vincent

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Structure-guided discovery of cyclin-dependent kinase inhibitors von Fischmann, Thierry O., Hruza, Alan, Duca, José S., Ramanathan, Lata, Mayhood, Todd, Windsor, William T., Le, Hung V., Guzi, Timothy J., Dwyer, Michael P., Paruch, Kamil, Doll, Ronald J., Lees, Emma, Parry, David, Seghezzi, Wolfgang, Madison, Vincent

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Human members of the eukaryotic protein kinase family von Kostich, Mitch, English, Jessie, Madison, Vincent, Gheyas, Ferdous, Wang, Luquan, Qiu, Ping, Greene, Jonathan, Laz, Thomas M

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Cross-Docking of Inhibitors into CDK2 Structures. 1 von Duca, José S, Madison, Vincent S, Voigt, Johannes H

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Cross-Docking of Inhibitors into CDK2 Structures. 2 von Voigt, Johannes H, Elkin, Carl, Madison, Vincent S, Duca, José S

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Impact of Naturally Occurring Variants of HCV Protease on the Binding of Different Classes of Protease Inhibitors von Tong, Xiao, Guo, Zhuyan, Wright-Minogue, Jacquelyn, Xia, Ellen, Prongay, Andrew, Madison, Vincent, Qiu, Ping, Venkatraman, Srikanth, Velazquez, Francisco, Njoroge, F. George, Malcolm, Bruce A.

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Crystal Structure of the Catalytic Domain of Human ADAM33 von Orth, Peter, Reichert, Paul, Wang, Wenyan, Prosise, Winifred W., Yarosh-Tomaine, Taisa, Hammond, Gerald, Ingram, Richard N., Xiao, Li, Mirza, Urooj A., Zou, Jun, Strickland, Corey, Taremi, S.Shane, Le, Hung V., Madison, Vincent

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Design and Synthesis of Depeptidized Macrocyclic Inhibitors of Hepatitis C NS3-4A Protease Using Structure-Based Drug Design von Venkatraman, Srikanth, Njoroge, F. George, Girijavallabhan, Viyyoor M, Madison, Vincent S, Yao, Nanua H, Prongay, Andrew J, Butkiewicz, Nancy, Pichardo, John

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Stabilization of the autoproteolysis of TNF-alpha converting enzyme (TACE) results in a novel crystal form suitable for structure-based drug design studies von Ingram, Richard N., Orth, Peter, Strickland, Corey L., Le, Hung V., Madison, Vincent, Beyer, Brian M.

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Insights from ab initio quantum chemical calculations into the preferred tautomeric forms and binding affinities to CDK2 of substituted pyrazolopyridines von Duca, José S., Madison, Vincent S.

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