Recent Advances in the Development of New Auristatins: Structural Modifications and Application in Antibody Drug Conjugates von Maderna, Andreas, Leverett, Carolyn A

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Synthesis, Molecular Editing, and Biological Assessment of the Potent Cytotoxin Leiodermatolide von Mailhol, Damien, Willwacher, Jens, Kausch-Busies, Nina, Rubitski, Elizabeth E, Sobol, Zhanna, Schuler, Maik, Lam, My-Hanh, Musto, Sylvia, Loganzo, Frank, Maderna, Andreas, Fürstner, Alois

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Total Syntheses and Biological Reassessment of Lactimidomycin, Isomigrastatin and Congener Glutarimide Antibiotics von Micoine, Kévin, Persich, Peter, Llaveria, Josep, Lam, My-Hanh, Maderna, Andreas, Loganzo, Frank, Fürstner, Alois

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Applications of Radiolabeled Boron Clusters to the Diagnosis and Treatment of Cancer von Hawthorne, M. Frederick, Maderna, Andreas

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NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells von Geles, Kenneth G., Gao, Yijie, Giannakou, Andreas, Sridharan, Latha, Yamin, Ting-Ting, Zhang, Jing, Karim, Riyez, Bard, Joel, Piche-Nicholas, Nicole, Charati, Manoj, Maderna, Andreas, Lucas, Judy, Golas, Jonathon, Guffroy, Magali, Pirie-Shepherd, Steven, Roy, Marc, Qian, Jessie, Franks, Tania, Zhong, Wenyan, O’Donnell, Christopher J., Tchistiakova, Lioudmila, Gerber, Hans-Peter, Sapra, Puja

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Synthesis of bicyclo[2.2.2]oct-5-en-2-ones via a tandem intermolecular Michael addition intramolecular aldol process (a bridged Robinson annulation) von Jung, Michael E., Maderna, Andreas

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Indexing Ultrafast Shape-Based Descriptors in MongoDB to Identify TLR4 Pathway Agonists von Polyakov, Valery R., Alexandrov, Vadim, Maderna, Andreas, Bajjuri, Krishna, Li, Xiaofan, Zhou, Sihong

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Building Machine Learning Small Molecule Melting Points and Solubility Models Using CCDC Melting Points Dataset von Zhu, Xiangwei, Polyakov, Valery R., Bajjuri, Krishna, Hu, Huiyong, Maderna, Andreas, Tovee, Clare A., Ward, Suzanna C.

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Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments von Loganzo, Frank, Tan, Xingzhi, Sung, Matthew, Jin, Guixian, Myers, Jeremy S, Melamud, Eugene, Wang, Fang, Diesl, Veronica, Follettie, Maximillian T, Musto, Sylvia, Lam, My-Hanh, Hu, William, Charati, Manoj B, Khandke, Kiran, Kim, Kenny Sung Kyoo, Cinque, Mike, Lucas, Judy, Graziani, Edmund, Maderna, Andreas, O'Donnell, Christopher J, Arndt, Kim T, Gerber, Hans-Peter

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Syntheses, Structures, and Reactivity of Hexaborylbenzene Derivatives von Ester, Christian, Maderna, Andreas, Pritzkow, Hans, Siebert, Walter

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Discovery of Cytotoxic Dolastatin 10 Analogues with N‑Terminal Modifications von Maderna, Andreas, Doroski, Matthew, Subramanyam, Chakrapani, Porte, Alexander, Leverett, Carolyn A, Vetelino, Beth C, Chen, Zecheng, Risley, Hud, Parris, Kevin, Pandit, Jayvardhan, Varghese, Alison H, Shanker, Suman, Song, Cynthia, Sukuru, Sai Chetan K, Farley, Kathleen A, Wagenaar, Melissa M, Shapiro, Michael J, Musto, Sylvia, Lam, My-Hanh, Loganzo, Frank, O’Donnell, Christopher J

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RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer von IVERSON, Cory, LARSON, Gary, HAMATAKE, Robert, MINER, Jeffrey N, QUART, Barry, LAI, Chon, YEH, Li-Tain, DADSON, Claudia, WEINGARTEN, Paul, APPLEBY, Todd, VO, Todd, MADERNA, Andreas, VERNIER, Jean-Michel

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Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia von Han, Yoon-Chi, Kahler, Jennifer, Piche-Nicholas, Nicole, Hu, Wenyue, Thibault, Stephane, Jiang, Fan, Leal, Mauricio, Katragadda, Madan, Maderna, Andreas, Dushin, Russell, Prashad, Nadira, Charati, Manoj B., Clark, Tracey, Tumey, L. Nathan, Tan, Xingzhi, Giannakou, Andreas, Rosfjord, Edward, Gerber, Hans-Peter, Tchistiakova, Lioudmila, Loganzo, Frank, O'Donnell, Christopher J., Sapra, Puja

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Synthesis of 3-methoxy-9-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annule n -4-ol, a potent antineoplastic benzosuberene derivative for anti-cancer chemotherapy von Chen, Zecheng, O'Donnell, Christopher J, Maderna, Andreas

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Synthesis of 3-methoxy-9-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5 H-benzo[7]annulen-4-ol, a potent antineoplastic benzosuberene derivative for anti-cancer chemotherapy von Chen, Zecheng, O’Donnell, Christopher J., Maderna, Andreas

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Abstract 3095: The development of CPI as a novel, next-generation DNA-targeting payload for ADCs von Kahler, Jennifer, Dougher, Maureen, Xu, Jane, Doroski, Matthew, Maderna, Andreas, Dushin, Russell, Thibault, Stephane, Leal, Mauricio, Katragadda, Madan, O'Donnell, Christopher J., Sung, Matthew, Sapra, Puja

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Novel Anti-TM4SF1 Antibody-Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature von Visintin, Alberto, Knowlton, Kelly, Tyminski, Edyta, Lin, Chi-Iou, Zheng, Xiang, Marquette, Kimberly, Jain, Sadhana, Tchistiakova, Lioudmila, Li, Dan, O'Donnell, Christopher J, Maderna, Andreas, Cao, Xianjun, Dunn, Robert, Snyder, William B, Abraham, Anson K, Leal, Mauricio, Shetty, Shoba, Barry, Anthony, Zawel, Leigh, Coyle, Anthony J, Dvorak, Harold F, Jaminet, Shou-Ching

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Synthesis of Tetraborylethenes and 1,1,1′,1′-Tetra- and Hexaborylethanes; Electronic Interactions in Tetraborylethenes and 1,1,1′,1′-Tetraborylethanes, and HF-SCF Calculations... von Bluhm, Martin, Maderna, Andreas, Pritzkow, Hans, Bethke, Sabine, Gleiter, Rolf, Siebert, Walter

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Abstract 935: Generation and preclinical characterization of CD123-CPI antibody-drug conjugate (ADC) von Han, Yoon-Chi, Jiang, Fan, Piche-Nicholas, Nicole, Katragadda, Madan, Prashad, Nadira, Charati, Manoj, Hu, Wendy, Leal, Mauricio, Tumey, Nathan, Maderna, Andreas, Dushin, Russell, Kim, Kenny, Lemon, LuAnna, Damelin, Marc, Gerber, HP, Tchistiakova, Lioudmila, Loganza, Frank, O'Donnell, Chris, Sapra, Puja

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Imidazo[1,5- a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis von Kim, Kyung-Hee, Maderna, Andreas, Schnute, Mark E., Hegen, Martin, Mohan, Shashi, Miyashiro, Joy, Lin, Laura, Li, Evelyn, Keegan, Sean, Lussier, Jennifer, Wrocklage, Christopher, Nickerson-Nutter, Cheryl L., Wittwer, Arthur J., Soutter, Holly, Caspers, Nicole, Han, Seungil, Kurumbail, Ravi, Dunussi-Joannopoulos, Kyri, Douhan, John, Wissner, Allan

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