Metal Catalyzed Synthesis of Dihydropyridobenzodiazepines von Maddess, Matthew L, Li, Chaomin

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A General Strategy for N‑(Hetero)arylpiperidine Synthesis Using Zincke Imine Intermediates von Selingo, Jake D., Greenwood, Jacob W., Andrews, Mary Katherine, Patel, Chirag, Neel, Andrew J., Pio, Barbara, Shevlin, Michael, Phillips, Eric M., Maddess, Matthew L., McNally, Andrew

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A kinase-cGAS cascade to synthesize a therapeutic STING activator von McIntosh, John A., Liu, Zhijian, Andresen, Brian M., Marzijarani, Nastaran Salehi, Moore, Jeffrey C., Marshall, Nicholas M., Borra-Garske, Margie, Obligacion, Jennifer V., Fier, Patrick S., Peng, Feng, Forstater, Jacob H., Winston, Matthew S., An, Chihui, Chang, Wonsuk, Lim, Jongwon, Huffman, Mark A., Miller, Steven P., Tsay, Fuh-Rong, Altman, Michael D., Lesburg, Charles A., Steinhuebel, Dietrich, Trotter, B. Wesley, Cumming, Jared N., Northrup, Alan, Bu, Xiaodong, Mann, Benjamin F., Biba, Mirlinda, Hiraga, Kaori, Murphy, Grant S., Kolev, Joshua N., Makarewicz, Amanda, Pan, Weilan, Farasat, Iman, Bade, Rachel S., Stone, Kevin, Duan, Da, Alvizo, Oscar, Adpressa, Donovan, Guetschow, Erik, Hoyt, Erik, Regalado, Erik L., Castro, Steve, Rivera, Nelo, Smith, Joseph P., Wang, Fengqiang, Crespo, Alejandro, Verma, Deeptak, Axnanda, Stephanus, Dance, Zachary E. X., Devine, Paul N., Tschaen, David, Canada, Keith A., Bulger, Paul G., Sherry, Benjamin D., Truppo, Matthew D., Ruck, Rebecca T., Campeau, Louis-Charles, Bennett, David Jonathan, Humphrey, Guy R., Campos, Kevin R., Maddess, Matthew L.

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Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer von Chang, Wonsuk, Altman, Michael D, Lesburg, Charles A, Perera, Samanthi A, Piesvaux, Jennifer A, Schroeder, Gottfried K, Wyss, Daniel F, Cemerski, Saso, Chen, Yiping, DiNunzio, Edward, Haidle, Andrew M, Ho, Thu, Kariv, Ilona, Knemeyer, Ian, Kopinja, Johnny E, Lacey, Brian M, Laskey, Jason, Lim, Jongwon, Long, Brian J, Ma, Yanhong, Maddess, Matthew L, Pan, Bo-Sheng, Presland, Jeremy P, Spooner, Edward, Steinhuebel, Dietrich, Truong, Quang, Zhang, Zhibo, Fu, Jianmin, Addona, George H, Northrup, Alan B, Parmee, Emma, Tata, James R, Bennett, David Jonathan, Cumming, Jared N, Siu, Tony, Trotter, B. Wesley

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Development of Scalable Routes to 1‑Bicyclo[1.1.1]pentylpyrazoles von Zarate, Cayetana, Ardolino, Michael, Morriello, Gregori J, Logan, Kaitlyn M, Kaplan, William P, Torres, Luis, Li, Derun, Chen, Meng, Li, Hongming, Su, Jing, Fuller, Peter, Maddess, Matthew L, Song, Zhiguo Jake

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Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity von Bryce, Dianne K, Ware, Chris M, Woodhouse, Janice D, Ciaccio, Paul J, Ellis, J Michael, Hegde, Laxminarayan G, Kuruvilla, Sabu, Maddess, Matthew L, Markgraf, Carrie G, Otte, Karin M, Poulet, Frederique M, Timmins, Lauren M, Kennedy, Matthew E, Fell, Matthew J

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1‑Heteroaryl‑1H‑Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease von Candito, David A., Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W., Lapointe, Blair T., Methot, Joey L., DeMong, Duane E., Graham, Thomas H., Kurukulasuriya, Ravi, Keylor, Mitchell H., Tong, Ling, Morriello, Gregori J., Acton, John J., Pio, Barbara, Liu, Weiguo, Scott, Jack D., Ardolino, Michael J., Martinot, Theodore A., Maddess, Matthew L., Yan, Xin, Gunaydin, Hakan, Palte, Rachel L., McMinn, Spencer E., Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C., Lesburg, Charles A., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Moy, Lily Y., Woodhouse, Janice D., Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A., Otte, Karin M., Kennedy, Matthew E., Bennett, David Jonathan, DiMauro, Erin F., Fell, Matthew J., Neelamkavil, Santhosh, Wood, Harold B., Fuller, Peter H., Ellis, J. Michael

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease von Candito, David A, Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W, Lapointe, Blair T, Methot, Joey L, DeMong, Duane E, Graham, Thomas H, Kurukulasuriya, Ravi, Keylor, Mitchell H, Tong, Ling, Morriello, Gregori J, Acton, John J, Pio, Barbara, Liu, Weiguo, Scott, Jack D, Ardolino, Michael J, Martinot, Theodore A, Maddess, Matthew L, Yan, Xin, Gunaydin, Hakan, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C, Lesburg, Charles A, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Moy, Lily Y, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A, Otte, Karin M, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Neelamkavil, Santhosh, Wood, Harold B, Fuller, Peter H, Ellis, J Michael

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Development of a Stereoselective Synthesis of (1R,4R)- and (1S,4S)‑2-Oxa-5-azabicyclo[2.2.2]octane von Maddess, Matthew L, Cleator, Ed, Morimoto, Mariko, Goodyear, Adrian, Dieguez-Vazquez, Alejandro, Gibb, Andrew, Kirtley, Andy, Wang, Jie, Qi, Ji, Kong, Lingzhu, Alam, Mahbub, Keen, Stephen, Oliver, Steven F, Wen, Xin, Lam, Yu-Hong

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Modeling a Crowdsourced Definition of Molecular Complexity von Sheridan, Robert P, Zorn, Nicolas, Sherer, Edward C, Campeau, Louis-Charles, Chang, Charlie (Zhenyu), Cumming, Jared, Maddess, Matthew L, Nantermet, Philippe G, Sinz, Christopher J, O’Shea, Paul D

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Process Safety Considerations for the Supply of a High-Energy Oxadiazole IDO1-Selective Inhibitor von Martinot, Theodore A, Ardolino, Michael, Chen, Lu, Lam, Yu-hong, Li, Chaomin, Maddess, Matthew L, Muzzio, Daniel, Qi, Ji, Saurí, Josep, Song, Zhiguo J, Tan, Lushi, Vickery, Thomas, Yin, Jingjun, Zhao, Ralph

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Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors von Huang, Chunhui, Fischer, Christian, Machacek, Michelle R, Bogen, Stephane, Biftu, Tesfaye, Huang, Xianhai, Reutershan, Michael H, Otte, Ryan, Hong, Qingmei, Wu, Zhicai, Yu, Yang, Park, Min, Chen, Lei, Biju, Purakkattle, Knemeyer, Ian, Lu, Ping, Kochansky, Christopher J, Hicks, Michael Brendan, Liu, Yong, Helmy, Roy, Fradera, Xavier, Donofrio, Anthony, Close, Josh, Maddess, Matthew L, White, Catherine, Sloman, David L, Sciammetta, Nunzio, Lu, Jun, Gibeau, Craig, Simov, Vladimir, Zhang, Hongjun, Fuller, Peter, Witter, David

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Total Synthesis of Rapamycin von Ley, Steven V., Tackett, Miles N., Maddess, Matthew L., Anderson, James C., Brennan, Paul E., Cappi, Michael W., Heer, Jag P., Helgen, Céline, Kori, Masakuni, Kouklovsky, Cyrille, Marsden, Stephen P., Norman, Joanne, Osborn, David P., Palomero, María Á., Pavey, John B. J., Pinel, Catherine, Robinson, Lesley A., Schnaubelt, Jürgen, Scott, James S., Spilling, Christopher D., Watanabe, Hidenori, Wesson, Kieron E., Willis, Michael C.

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Total Synthesis of Rapamycin von Maddess, Matthew L., Tackett, Miles N., Watanabe, Hidenori, Brennan, Paul E., Spilling, Christopher D., Scott, James S., Osborn, David P., Ley, Steven V.

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Total Synthesis of Cryptophycin Analogues via a Scaffold Approach von McCubbin, J. Adam, Maddess, Matthew L, Lautens, Mark

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Chemoselective Cross Metathesis of Bishomoallylic Alcohols:  Rapid Access to Fragment A of the Cryptophycins von Lautens, Mark, Maddess, Matthew L

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Carboxamide Spleen Tyrosine Kinase (Syk) Inhibitors: Leveraging Ground State Interactions To Accelerate Optimization von Ellis, J. Michael, Altman, Michael D, Cash, Brandon, Haidle, Andrew M, Kubiak, Rachel L, Maddess, Matthew L, Yan, Youwei, Northrup, Alan B

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Enantioselective Synthesis of a Highly Substituted Tetrahydrofluorene Derivative as a Potent and Selective Estrogen Receptor Beta Agonist von Maddess, Matthew L, Scott, Jeremy P, Alorati, Anthony, Baxter, Carl, Bremeyer, Nadine, Brewer, Sarah, Campos, Kevin, Cleator, Ed, Dieguez-Vazquez, Alejandro, Gibb, Andrew, Gibson, Andrew, Howard, Melissa, Keen, Stephen, Klapars, Artis, Lee, Jaemoon, Li, Jing, Lynch, Joseph, Mullens, Peter, Wallace, Debra, Wilson, Robert

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Convenient Access to Functionalized Vinylcyclopentenols from Alkynyloxiranes von Wang, Letian, Maddess, Matthew L, Lautens, Mark

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Preparation of Homoallylic Homopropargylic Alcohols from 2-Vinyloxiranes von Maddess, Matthew L, Lautens, Mark

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