Programmable protein delivery with a bacterial contractile injection system von Kreitz, Joseph, Friedrich, Mirco J., Guru, Akash, Lash, Blake, Saito, Makoto, Macrae, Rhiannon K., Zhang, Feng

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Fanzor is a eukaryotic programmable RNA-guided endonuclease von Saito, Makoto, Xu, Peiyu, Faure, Guilhem, Maguire, Samantha, Kannan, Soumya, Altae-Tran, Han, Vo, Sam, Desimone, AnAn, Macrae, Rhiannon K., Zhang, Feng

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Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery von Segel, Michael, Lash, Blake, Song, Jingwei, Ladha, Alim, Liu, Catherine C, Jin, Xin, Mekhedov, Sergei L, Macrae, Rhiannon K, Koonin, Eugene V, Zhang, Feng

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The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases von Altae-Tran, Han, Kannan, Soumya, Demircioglu, F Esra, Oshiro, Rachel, Nety, Suchita P, McKay, Luke J, Dlakić, Mensur, Inskeep, William P, Makarova, Kira S, Macrae, Rhiannon K, Koonin, Eugene V, Zhang, Feng

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Prokaryotic innate immunity through pattern recognition of conserved viral proteins von Gao, Linyi Alex, Wilkinson, Max E, Strecker, Jonathan, Makarova, Kira S, Macrae, Rhiannon K, Koonin, Eugene V, Zhang, Feng

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Dual modes of CRISPR-associated transposon homing von Saito, Makoto, Ladha, Alim, Strecker, Jonathan, Faure, Guilhem, Neumann, Edwin, Altae-Tran, Han, Macrae, Rhiannon K., Zhang, Feng

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Structure of the R2 non-LTR retrotransposon initiating target-primed reverse transcription von Wilkinson, Max E, Frangieh, Chris J, Macrae, Rhiannon K, Zhang, Feng

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Cell type-specific delivery by modular envelope design von Strebinger, Daniel, Frangieh, Chris J., Friedrich, Mirco J., Faure, Guilhem, Macrae, Rhiannon K., Zhang, Feng

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Structural determinants of DNA cleavage by a CRISPR HNH-Cascade system von Hirano, Seiichi, Altae-Tran, Han, Kannan, Soumya, Macrae, Rhiannon K., Zhang, Feng

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CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity von Joung, Julia, Kirchgatterer, Paul C., Singh, Ankita, Cho, Jang H., Nety, Suchita P., Larson, Rebecca C., Macrae, Rhiannon K., Deasy, Rebecca, Tseng, Yuen-Yi, Maus, Marcela V., Zhang, Feng

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Phage-triggered reverse transcription assembles a toxic repetitive gene from a noncoding RNA von Wilkinson, Max E, Li, David, Gao, Alex, Macrae, Rhiannon K, Zhang, Feng

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Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing von Joung, Julia, Ladha, Alim, Saito, Makoto, Kim, Nam-Gyun, Woolley, Ann E, Segel, Michael, Barretto, Robert P.J, Ranu, Amardeep, Macrae, Rhiannon K, Faure, Guilhem, Ioannidi, Eleonora I, Krajeski, Rohan N, Bruneau, Robert, Huang, Meei-Li W, Yu, Xu G, Li, Jonathan Z, Walker, Bruce D, Hung, Deborah T, Greninger, Alexander L, Jerome, Keith R, Gootenberg, Jonathan S, Abudayyeh, Omar O, Zhang, Feng

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RNA-activated protein cleavage with a CRISPR-associated endopeptidase von Strecker, Jonathan, Demircioglu, F Esra, Li, David, Faure, Guilhem, Wilkinson, Max E, Gootenberg, Jonathan S, Abudayyeh, Omar O, Nishimasu, Hiroshi, Macrae, Rhiannon K, Zhang, Feng

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A transcription factor atlas of directed differentiation von Joung, Julia, Ma, Sai, Tay, Tristan, Geiger-Schuller, Kathryn R., Kirchgatterer, Paul C., Verdine, Vanessa K., Guo, Baolin, Arias-Garcia, Mario A., Allen, William E., Singh, Ankita, Kuksenko, Olena, Abudayyeh, Omar O., Gootenberg, Jonathan S., Fu, Zhanyan, Macrae, Rhiannon K., Buenrostro, Jason D., Regev, Aviv, Zhang, Feng

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Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral capsids that can be engineered for mRNA delivery von Madigan, Victoria, Zhang, Yugang, Raghavan, Rumya, Wilkinson, Max E, Faure, Guilhem, Puccio, Elena, Segel, Michael, Lash, Blake, Macrae, Rhiannon K, Zhang, Feng

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Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering von Altae-Tran, Han, Kannan, Soumya, Suberski, Anthony J, Mears, Kepler S, Demircioglu, F Esra, Moeller, Lukas, Kocalar, Selin, Oshiro, Rachel, Makarova, Kira S, Macrae, Rhiannon K, Koonin, Eugene V, Zhang, Feng

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Structure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9 von Kato, Kazuki, Okazaki, Sae, Kannan, Soumya, Altae-Tran, Han, Esra Demircioglu, F., Isayama, Yukari, Ishikawa, Junichiro, Fukuda, Masahiro, Macrae, Rhiannon K., Nishizawa, Tomohiro, Makarova, Kira S., Koonin, Eugene V., Zhang, Feng, Nishimasu, Hiroshi

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Rational engineering of minimally immunogenic nucleases for gene therapy von Raghavan, Rumya, Friedrich, Mirco J., King, Indigo, Chau-Duy-Tam Vo, Samuel, Strebinger, Daniel, Lash, Blake, Kilian, Michael, Platten, Michael, Macrae, Rhiannon K., Song, Yifan, Nivon, Lucas, Zhang, Feng

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Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA von Hirano, Seiichi, Kappel, Kalli, Altae-Tran, Han, Faure, Guilhem, Wilkinson, Max E., Kannan, Soumya, Demircioglu, F. Esra, Yan, Rui, Shiozaki, Momoko, Yu, Zhiheng, Makarova, Kira S., Koonin, Eugene V., Macrae, Rhiannon K., Zhang, Feng

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Modularity and diversity of target selectors in Tn7 transposons von Faure, Guilhem, Saito, Makoto, Benler, Sean, Peng, Iris, Wolf, Yuri I., Strecker, Jonathan, Altae-Tran, Han, Neumann, Edwin, Li, David, Makarova, Kira S., Macrae, Rhiannon K., Koonin, Eugene V., Zhang, Feng

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