A new class of ratiometric small molecule intracellular pH sensors for Raman microscopy von Wilson, Liam T, Tipping, William J, Jamieson, Lauren E, Wetherill, Corinna, Henley, Zoë, Faulds, Karen, Graham, Duncan, Mackay, Simon P, Tomkinson, Nicholas C. O

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Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activati... von Wiejak, Jolanta, Dunlop, Julia, Mackay, Simon P, Yarwood, Stephen J

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Design and Synthesis of Novel Aminoindazole-pyrrolo[2,3- b ]pyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling von Riley, Christopher, Ammar, Usama, Alsfouk, Aisha, Anthony, Nahoum G, Baiget, Jessica, Berretta, Giacomo, Breen, David, Huggan, Judith, Lawson, Christopher, McIntosh, Kathryn, Plevin, Robin, Suckling, Colin J, Young, Louise C, Paul, Andrew, Mackay, Simon P

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Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes von Indorato, Rose-Laure, Talapatra, Sandeep K, Lin, Fangzhu, Haider, Shozeb, Mackay, Simon P, Kozielski, Frank, Skoufias, Dimitrios A

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Structure–Activity Relationships and Molecular Modeling of Sphingosine Kinase Inhibitors von Baek, Dong Jae, MacRitchie, Neil, Anthony, Nahoum G, Mackay, Simon P, Pyne, Susan, Pyne, Nigel J, Bittman, Robert

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Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate SB743921 by an Allosteric Resistance Mechanism von Talapatra, Sandeep K, Anthony, Nahoum G, Mackay, Simon P, Kozielski, Frank

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Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH von Al-Balas, Qosay, Anthony, Nahoum G, Al-Jaidi, Bilal, Alnimr, Amani, Abbott, Grainne, Brown, Alistair K, Taylor, Rebecca C, Besra, Gurdyal S, McHugh, Timothy D, Gillespie, Stephen H, Johnston, Blair F, Mackay, Simon P, Coxon, Geoffrey D

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IL-1β stimulates a novel axis within the NFκB pathway in endothelial cells regulated by IKKα and TAK-1 von Craig, Rachel, McIntosh, Kathryn, Ho Ho, Ka, McCulloch, Ashley, Riley, Christopher, Lawson, Christopher, Mackay, Simon P., Paul, Andrew, Coats, Paul, Plevin, Robin

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Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0) von Llona-Minguez, Sabin, Mackay, Simon P

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Antimicrobial Lexitropsins Containing Amide, Amidine, and Alkene Linking Groups von Anthony, Nahoum G, Breen, David, Clarke, Joanna, Donoghue, Gavin, Drummond, Allan J, Ellis, Elizabeth M, Gemmell, Curtis G, Helesbeux, Jean-Jacques, Hunter, Iain S, Khalaf, Abedawn I, Mackay, Simon P, Parkinson, John A, Suckling, Colin J, Waigh, Roger D

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The Drug Discovery Portal: a resource to enhance drug discovery from academia von Clark, Rachel L., Johnston, Blair F., Mackay, Simon P., Breslin, Catherine J., Robertson, Murray N., Harvey, Alan L.

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Mitokyne: A Ratiometric Raman Probe for Mitochondrial pH von Wilson, Liam T, Tipping, William J, Wetherill, Corinna, Henley, Zoë, Faulds, Karen, Graham, Duncan, Mackay, Simon P, Tomkinson, Nicholas C. O

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Topographical Mapping of Isoform-Selectivity Determinants for J‑Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2 von Adams, David R, Tawati, Salha, Berretta, Giacomo, Rivas, Paula Lopez, Baiget, Jessica, Jiang, Zhong, Alsfouk, Aisha, Mackay, Simon P, Pyne, Nigel J, Pyne, Susan

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Determining the prognostic significance of IKKα in prostate cancer von Montes, Melania, MacKenzie, Lewis, McAllister, Milly J., Roseweir, Antonia, McCall, Pamela, Hatziieremia, Sophia, Underwood, Mark A., Boyd, Marie, Paul, Andrew, Plevin, Robin, MacKay, Simon P., Edwards, Joanne

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Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinine von Baiget, Jessica, Llona-Minguez, Sabin, Lang, Stuart, Mackay, Simon P, Suckling, Colin J, Sutcliffe, Oliver B

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Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers von Anthony, Nahoum G, Baiget, Jessica, Berretta, Giacomo, Boyd, Marie, Breen, David, Edwards, Joanne, Gamble, Carly, Gray, Alexander I, Harvey, Alan L, Hatziieremia, Sophia, Ho, Ka Ho, Huggan, Judith K, Lang, Stuart, Llona-Minguez, Sabin, Luo, Jia Lin, McIntosh, Kathryn, Paul, Andrew, Plevin, Robin J, Robertson, Murray N, Scott, Rebecca, Suckling, Colin J, Sutcliffe, Oliver B, Young, Louise C, Mackay, Simon P

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Synthesis, biological activity and comparative analysis of DNA binding affinities and human DNA topoisomerase I inhibitory activities of novel 12-alkoxy-benzo[ c]phenanthridinium s... von Lynch, Michael A, Duval, Olivier, Sukhanova, Alyona, Devy, Jerome, MacKay, Simon P, Waigh, Roger D, Nabiev, Igor

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Synthetic biological approaches for RNA labelling and imaging: design principles and future opportunities von Pauff, Steven, Withers, Jamie M, McKean, Iain JW, Mackay, Simon P, Burley, Glenn A

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Targeting the Non-Canonical NF-κB Pathway in Chronic Lymphocytic Leukemia and Multiple Myeloma von Burley, Thomas A, Kennedy, Emma, Broad, Georgia, Boyd, Melanie, Li, David, Woo, Timothy, West, Christopher, Ladikou, Eleni E, Ashworth, Iona, Fegan, Christopher, Johnston, Rosalynd, Mitchell, Simon, Mackay, Simon P, Pepper, Andrea G S, Pepper, Chris

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Confined compression of collagen hydrogels von Busby, Grahame A, Grant, M. Helen, MacKay, Simon P, Riches, Philip E

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