Predicting the Stereochemistry of Diphenylphosphino Benzoic Acid (DPPBA)-Based Palladium-Catalyzed Asymmetric Allylic Alkylation Reactions:  A Working Model von Trost, Barry M, Machacek, Michelle R, Aponick, Aaron

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NMR Data‐Driven Docking of HDM2‐Inhibitor Complexes von Fradera, Xavier, Reutershan, Michael H., Machacek, Michelle R., Trotter, B. Wesley, McCoy, Mark A.

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Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity von Kawamura, Shuhei, Palte, Rachel L., Kim, Hai-Young, Saurí, Josep, Sondey, Christopher, Mansueto, My S., Altman, Michael D., Machacek, Michelle R.

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Discovery of MK-4688: an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction von Reutershan, Michael H, Machacek, Michelle R, Altman, Michael D, Bogen, Stephane, Cai, Mingmei, Cammarano, Carolyn, Chen, Dapeng, Christopher, Matthew, Cryan, John, Daublain, Pierre, Fradera, Xavier, Geda, Prasanthi, Goldenblatt, Peter, Hill, Armetta D, Kemper, Raymond A, Kutilek, Victoria, Li, Chaomin, Martinez, Michelle, McCoy, Mark, Nair, Latha, Pan, Weidong, Thompson, Christopher F, Scapin, Giovanna, Shizuka, Manami, Spatz, Marianne L, Steinhuebel, Dietrich, Sun, Binyuan, Voss, Matthew E, Wang, Xiao, Yang, Liping, Yeh, Tammie C, Dussault, Isabelle, Marshall, C. Gary, Trotter, B. Wesley

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The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer von Quiroz, Ryan V, Reutershan, Michael H, Schneider, Sebastian E, Sloman, David, Lacey, Brian M, Swalm, Brooke M, Yeung, Charles S, Gibeau, Craig, Spellman, Daniel S, Rankic, Danica A, Chen, Dapeng, Witter, David, Linn, Doug, Munsell, Erik, Feng, Guo, Xu, Haiyan, Hughes, Jonathan M. E, Lim, Jongwon, Saurí, Josep, Geddes, Kristin, Wan, Murray, Mansueto, My Sam, Follmer, Nicole E, Fier, Patrick S, Siliphaivanh, Phieng, Daublain, Pierre, Palte, Rachel L, Hayes, Robert P, Lee, Sandra, Kawamura, Shuhei, Silverman, Steven, Sanyal, Sulagna, Henderson, Timothy J, Ye, Yingchun, Gao, Yuanwei, Nicholson, Benjamin, Machacek, Michelle R

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Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5) von Palte, Rachel L, Schneider, Sebastian E, Altman, Michael D, Hayes, Robert P, Kawamura, Shuhei, Lacey, Brian M, Mansueto, My Sam, Reutershan, Michael, Siliphaivanh, Phieng, Sondey, Christopher, Xu, Haiyan, Xu, Zangwei, Ye, Yingchun, Machacek, Michelle R

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Sequential Ru−Pd Catalysis:  A Two-Catalyst One-Pot Protocol for the Synthesis of N- and O-Heterocycles von Trost, Barry M, Machacek, Michelle R, Faulk, Brian D

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Ruthenium-Catalyzed Vinylsilane Synthesis and Cross-Coupling as a Selective Approach to Alkenes:  Benzyldimethylsilyl as a Robust Vinylmetal Functionality von Trost, Barry M, Machacek, Michelle R, Ball, Zachary T

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Development of Aliphatic Alcohols as Nucleophiles for Palladium-Catalyzed DYKAT Reactions:  Total Synthesis of (+)-Hippospongic Acid A von Trost, Barry M, Machacek, Michelle R, Tsui, Hong C

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A one-step, multi-component reaction for the synthesis of fully substituted 5-amino-4-carboxamidthiazoles von Childers, Kaleen K., Haidle, Andrew M., Machacek, Michelle R., Rogers, J. Patrick, Romeo, Eric

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A Poly(p-phenyleneethynylene) with a Highly Emissive Aggregated Phase von Deans, Robert, Kim, Jinsang, Machacek, Michelle R, Swager, Timothy M

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Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors von Huang, Chunhui, Fischer, Christian, Machacek, Michelle R, Bogen, Stephane, Biftu, Tesfaye, Huang, Xianhai, Reutershan, Michael H, Otte, Ryan, Hong, Qingmei, Wu, Zhicai, Yu, Yang, Park, Min, Chen, Lei, Biju, Purakkattle, Knemeyer, Ian, Lu, Ping, Kochansky, Christopher J, Hicks, Michael Brendan, Liu, Yong, Helmy, Roy, Fradera, Xavier, Donofrio, Anthony, Close, Josh, Maddess, Matthew L, White, Catherine, Sloman, David L, Sciammetta, Nunzio, Lu, Jun, Gibeau, Craig, Simov, Vladimir, Zhang, Hongjun, Fuller, Peter, Witter, David

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An Efficient One-Pot Enantio- and Diastereoselective Synthesis of Heterocycles von Trost, Barry M., Machacek, Michelle R.

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Racemic Synthesis of a Key 1,4-Dihydro‑2H‑spiro[isoquinoline-3,4′-piperidin]-3′-ol Building Block von Candito, David A., Martinot, Theodore A., Su, Jing, Saurí, Josep, Lam, Yu-hong, Joyce, Leo A., Silverman, Steven M., Sloman, David L., Maddess, Matthew L., Machacek, Michelle R.

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Racemic Synthesis of a Key 1,4-Dihydro-2 H -spiro[isoquinoline-3,4′-piperidin]-3′-ol Building Block von Candito, David A., Martinot, Theodore A., Su, Jing, Saurí, Josep, Lam, Yu-hong, Joyce, Leo A., Silverman, Steven M., Sloman, David L., Maddess, Matthew L., Machacek, Michelle R.

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Identification of free fatty acid receptor 2 agonists using virtual screening von Fells, James I., Ai, Xi, Weinglass, Adam, Feng, Wen, Lei, Ying, Finley, Michael, Hoveyda, Hamid R., Fraser, Graeme L., Machacek, Michelle

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Abstract LB-029: Identification of predictive genetic signatures of Cytarabine responsiveness in acute myeloid leukemia using a novel 3D translational culture model of primary bone... von Xu, Haiyan, Muise, Eric S., Javaid, Sarah, Chen, Lan, Cristescu, Razvan, Mansueto, My Sam, Follmer, Nicole, Cho, Jennifer, Kerr, Kimberley, Altura, Rachel, Machacek, Michelle, Nicholson, Benjamin, Addona, George, Kariv, Ilona, Chen, Hongmin

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Identification of predictive genetic signatures of Cytarabine responsiveness using a 3D acute myeloid leukaemia model von Xu, Haiyan, Muise, Eric S., Javaid, Sarah, Chen, Lan, Cristescu, Razvan, Mansueto, My Sam, Follmer, Nicole, Cho, Jennifer, Kerr, Kimberley, Altura, Rachel, Machacek, Michelle, Nicholson, Benjamin, Addona, George, Kariv, Ilona, Chen, Hongmin

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Biochemical Characterization of Heterodimeric Isocitrate Dehydrogenase I Using a Novel High‐throughput Mass Spectrometry‐based Assay von Piesvaux, Jennifer, Miller, Richard, McCoy, Mark, Hou, Yan, Spacciapoli, Peter, Fischer, Christian, Machacek, Michelle, Fradera, Xavier

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Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species von Stachel, Shawn J., Egbertson, Melissa S., Wai, Jenny, Machacek, Michelle, Toolan, Dawn M., Swestock, John, Eddins, Donnie M., Puri, Vanita, McGaughey, Georgia, Su, Hua-Poo, Perlow, Debbie, Wang, Deping, Ma, Lei, Parthasarathy, Gopal, Reid, John C., Abeywickrema, Pravien D., Smith, Sean M., Uslaner, Jason M.

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