NRG1 Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in KRAS Wild-Type Pancreatic Ductal Adenocarcinoma von Jones, Martin R, Williamson, Laura M, Topham, James T, Lee, Michael K C, Goytain, Angela, Ho, Julie, Denroche, Robert E, Jang, GunHo, Pleasance, Erin, Shen, Yaoquing, Karasinska, Joanna M, McGhie, John P, Gill, Sharlene, Lim, Howard J, Moore, Malcolm J, Wong, Hui-Li, Ng, Tony, Yip, Stephen, Zhang, Wei, Sadeghi, Sara, Reisle, Carolyn, Mungall, Andrew J, Mungall, Karen L, Moore, Richard A, Ma, Yussanne, Knox, Jennifer J, Gallinger, Steven, Laskin, Janessa, Marra, Marco A, Schaeffer, David F, Jones, Steven J M, Renouf, Daniel J

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Diagnostic and Therapeutic Implications of a FUS::TFCP2 Fusion and ALK Activation in a Metastatic Rhabdomyosarcoma von Csizmok, Veronika, Grisdale, Cameron J., Williamson, Laura M., Lim, Howard J., Lee, Lawrence, Renouf, Daniel J., Jones, Steven J. M., Marra, Marco A., Laskin, Janessa, Smrke, Alannah

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Determining the Structural and Energetic Basis of Allostery in a De Novo Designed Metalloprotein Assembly von Churchfield, Lewis A, Alberstein, Robert G, Williamson, Laura M, Tezcan, F. Akif

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Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma von Topham, James T., Tsang, Erica S., Karasinska, Joanna M., Metcalfe, Andrew, Ali, Hassan, Kalloger, Steve E., Csizmok, Veronika, Williamson, Laura M., Titmuss, Emma, Nielsen, Karina, Negri, Gian Luca, Spencer Miko, Sandra E., Jang, Gun Ho, Denroche, Robert E., Wong, Hui-li, O’Kane, Grainne M., Moore, Richard A., Mungall, Andrew J., Loree, Jonathan M., Notta, Faiyaz, Wilson, Julie M., Bathe, Oliver F., Tang, Patricia A., Goodwin, Rachel, Morin, Gregg B., Knox, Jennifer J., Gallinger, Steven, Laskin, Janessa, Marra, Marco A., Jones, Steven J. M., Schaeffer, David F., Renouf, Daniel J.

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Subtype-Discordant Pancreatic Ductal Adenocarcinoma Tumors Show Intermediate Clinical and Molecular Characteristics von Topham, James T, Karasinska, Joanna M, Lee, Michael K C, Csizmok, Veronika, Williamson, Laura M, Jang, Gun Ho, Denroche, Robert E, Tsang, Erica S, Kalloger, Steve E, Wong, Hui-Li, O'Kane, Grainne M, Moore, Richard A, Mungall, Andrew J, Notta, Faiyaz, Loree, Jonathan M, Wilson, Julie M, Bathe, Oliver, Tang, Patricia A, Goodwin, Rachel, Knox, Jennifer J, Gallinger, Steven, Laskin, Janessa, Marra, Marco A, Jones, Steven J M, Renouf, Daniel J, Schaeffer, David F

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Whole genome and transcriptome integrated analyses guide clinical care of pediatric poor prognosis cancers von Deyell, Rebecca J., Shen, Yaoqing, Titmuss, Emma, Dixon, Katherine, Williamson, Laura M., Pleasance, Erin, Nelson, Jessica M. T., Abbasi, Sanna, Krzywinski, Martin, Armstrong, Linlea, Bonakdar, Melika, Ch’ng, Carolyn, Chuah, Eric, Dunham, Chris, Fok, Alexandra, Jones, Martin, Lee, Anna F., Ma, Yussanne, Moore, Richard A., Mungall, Andrew J., Mungall, Karen L., Rogers, Paul C., Schrader, Kasmintan A., Virani, Alice, Wee, Kathleen, Young, Sean S., Zhao, Yongjun, Jones, Steven J. M., Laskin, Janessa, Marra, Marco A., Rassekh, Shahrad R.

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A platform for oncogenomic reporting and interpretation von Reisle, Caralyn, Williamson, Laura M., Pleasance, Erin, Davies, Anna, Pellegrini, Brayden, Bleile, Dustin W., Mungall, Karen L., Chuah, Eric, Jones, Martin R., Ma, Yussanne, Lewis, Eleanor, Beckie, Isaac, Pham, David, Matiello Pletz, Raphael, Muhammadzadeh, Amir, Pierce, Brandon M., Li, Jacky, Stevenson, Ross, Wong, Hansen, Bailey, Lance, Reisle, Abbey, Douglas, Matthew, Bonakdar, Melika, Nelson, Jessica M. T., Grisdale, Cameron J., Krzywinski, Martin, Fisic, Ana, Mitchell, Teresa, Renouf, Daniel J., Yip, Stephen, Laskin, Janessa, Marra, Marco A., Jones, Steven J. M.

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Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration von Tsang, Erica S., Csizmok, Veronika, Williamson, Laura M., Pleasance, Erin, Topham, James T., Karasinska, Joanna M., Titmuss, Emma, Schrader, Intan, Yip, Stephen, Tessier-Cloutier, Basile, Mungall, Karen, Ng, Tony, Sun, Sophie, Lim, Howard J., Loree, Jonathan M., Laskin, Janessa, Marra, Marco A., Jones, Steven J. M., Schaeffer, David F., Renouf, Daniel J.

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Exploration of Germline Correlates and Risk of Immune-Related Adverse Events in Advanced Cancer Patients Treated with Immune Checkpoint Inhibitors von Titmuss, Emma, Yu, Irene S, Pleasance, Erin D, Williamson, Laura M, Mungall, Karen, Mungall, Andrew J, Renouf, Daniel J, Moore, Richard, Jones, Steven J M, Marra, Marco A, Laskin, Janessa J, Savage, Kerry J

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TMBur: a distributable tumor mutation burden approach for whole genome sequencing von Titmuss, Emma, Corbett, Richard D, Davidson, Scott, Abbasi, Sanna, Williamson, Laura M, Pleasance, Erin D, Shlien, Adam, Renouf, Daniel J, Jones, Steven J. M, Laskin, Janessa, Marra, Marco A

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Clinical response to nivolumab in an INI1-deficient pediatric chordoma correlates with immunogenic recognition of brachyury von Williamson, Laura M., Rive, Craig M., Di Francesco, Daniela, Titmuss, Emma, Chun, Hye-Jung E., Brown, Scott D., Milne, Katy, Pleasance, Erin, Lee, Anna F., Yip, Stephen, Rosenbaum, Daniel G., Hasselblatt, Martin, Johann, Pascal D., Kool, Marcel, Harvey, Melissa, Dix, David, Renouf, Daniel J., Holt, Robert A., Nelson, Brad H., Hirst, Martin, Jones, Steven J. M., Laskin, Janessa, Rassekh, Shahrad R., Deyell, Rebecca J., Marra, Marco A.

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Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers von Romero, Joan Miguel, Titmuss, Emma, Wang, Yifan, Vafiadis, James, Pacis, Alain, Jang, Gun Ho, Zhang, Amy, Golesworthy, Bryn, Lenko, Tatiana, Williamson, Laura M., Grünwald, Barbara, O’Kane, Grainne M., Jones, Steven J. M., Marra, Marco. A., Wilson, Julie M., Gallinger, Steven, Laskin, Janessa, Zogopoulos, George

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Altered Gene Expression along the Glycolysis-Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer von Karasinska, Joanna M, Topham, James T, Kalloger, Steve E, Jang, Gun Ho, Denroche, Robert E, Culibrk, Luka, Williamson, Laura M, Wong, Hui-Li, Lee, Michael K C, O'Kane, Grainne M, Moore, Richard A, Mungall, Andrew J, Moore, Malcolm J, Warren, Cassia, Metcalfe, Andrew, Notta, Faiyaz, Knox, Jennifer J, Gallinger, Steven, Laskin, Janessa, Marra, Marco A, Jones, Steven J M, Renouf, Daniel J, Schaeffer, David F

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Chemical Genetics of Zipper-interacting Protein Kinase Reveal Myosin Light Chain as a Bona Fide Substrate in Permeabilized Arterial Smooth Muscle von Moffat, Lori D., Brown, Shannon B.A., Grassie, Michael E., Ulke-Lemée, Annegret, Williamson, Laura M., Walsh, Michael P., MacDonald, Justin A.

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Genomic characterization of a well-differentiated grade 3 pancreatic neuroendocrine tumor von Williamson, Laura M, Steel, Michael, Grewal, Jasleen K, Thibodeau, My Lihn, Zhao, Eric Y, Loree, Jonathan M, Yang, Kevin C, Gorski, Sharon M, Mungall, Andrew J, Mungall, Karen L, Moore, Richard A, Marra, Marco A, Laskin, Janessa, Renouf, Daniel J, Schaeffer, David F, Jones, Steven J M

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Genome and Transcriptome Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Solid Tumors von Pender, Alexandra, Titmuss, Emma, Pleasance, Erin D, Fan, Kevin Y, Pearson, Hillary, Brown, Scott D, Grisdale, Cameron J, Topham, James T, Shen, Yaoqing, Bonakdar, Melika, Taylor, Gregory A, Williamson, Laura M, Mungall, Karen L, Chuah, Eric, Mungall, Andrew J, Moore, Richard A, Lavoie, Jean-Michel, Yip, Stephen, Lim, Howard, Renouf, Daniel J, Sun, Sophie, Holt, Robert A, Jones, Steven J M, Marra, Marco A, Laskin, Janessa

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Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks von WILLIAMSON, Laura M, LEES-MILLER, Susan P

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Redox-Dependent Metastability of the Nitrogenase P‑Cluster von Rutledge, Hannah L, Rittle, Jonathan, Williamson, Laura M, Xu, Wanqing A, Gagnon, Derek M, Tezcan, F. Akif

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Enhancing clinical genomic accuracy with panelGC: a novel metric and tool for quantifying and monitoring GC biases in hybridization capture panel sequencing von Cheng, Xuanjin, Goktas, Murathan T, Williamson, Laura M, Krzywinski, Martin, Mulder, David T, Swanson, Lucas, Slind, Jill, Sihvonen, Jelena, Chow, Cynthia R, Carr, Amy, Bosdet, Ian, Tucker, Tracy, Young, Sean, Moore, Richard, Mungall, Karen L, Yip, Stephen, Jones, Steven J M

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Delving into Early-onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In? von Tsang, Erica S, Topham, James T, Karasinska, Joanna M, Lee, Michael K C, Williamson, Laura M, Mendis, Shehara, Denroche, Robert E, Jang, Gun Ho, Kalloger, Steve E, Moore, Richard A, Mungall, Andrew J, Bathe, Oliver F, Tang, Patricia A, Notta, Faiyaz, Wilson, Julie M, Laskin, Janessa, O'Kane, Grainne M, Knox, Jennifer J, Goodwin, Rachel A, Loree, Jonathan M, Jones, Steven J M, Marra, Marco A, Gallinger, Steven, Schaeffer, David F, Renouf, Daniel J

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