Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives von Pauwels, Rudi, Andries, Koen, Desmyter, Jan, Schols, Dominique, Kukla, Michael J, Breslin, Henry J, Raeymaeckers, Alfons, Gelder, Jozef Van, Woestenborghs, Robert, Heykants, Jozef, Schellekens, Karel, Janssen, Marcel A. C, Clercq, Erik De, Janssen, Paul A. J

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New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic wi... von PAUWELS, R, ANDRIES, K, JANSSEN, P. A. J, DEBYSER, Z, KUKLA, M. J, SCHOLS, D, BRESLIN, H. J, WOESTENBORGHS, R, DESMYTER, J, JANSSEN, M. A. C, DE CLERCQ, E

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Evolution of anti-HIV drug candidates. Part 3: diarylpyrimidine (DAPY) analogues von Ludovici, Donald W., De Corte, Bart L., Kukla, Michael J., Ye, Hong, Ho, Chih Y., Lichtenstein, Mark A., Kavash, Robert W., Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, Lewi, Paul J., Heeres, Jan, Koymans, Lucien M.H., de Jonge, Marc R., Van Aken, Koen J.A., Daeyaert, Frederik F.D., Das, Kalyan, Arnold, Edward, Janssen, Paul A.J.

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Evolution of anti-HIV drug candidates. Part 2 : Diaryltriazine (DATA) analogues von LUDOVICI, Donald W, KAVASH, Robert W, MOEREELS, Henry E. L, HEERES, Jan, KOYMANS, Lucien M. H, DE JONGE, Marc R, VAN AKEN, Koen J. A, DAEYAERT, Frederik F. D, LEWI, Paul J, DAS, Kalyan, ARNOLD, Edward, JANSSEN, Paul A. J, KUKLA, Michael J, HO, Chih Y, HONG YE, DE CORTE, Bart L, ANDRIES, Koen, DE BETHUNE, Marie-Pierre, AZIJN, Hilde, PAUWELS, Rudi

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Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives von Kukla, Michael J, Breslin, Henry J, Pauwels, Rudi, Fedde, Cynthia L, Miranda, Milton, Scott, Malcolm K, Sherrill, Ronald G, Raeymaekers, Alfons, Van Gelder, Jozef

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Evolution of anti-HIV drug candidates. Part 1: From α-Anilinophenylacetamide (α-APA) to imidoyl thiourea (ITU) von Ludovici, Donald W., Kukla, Michael J., Grous, Philip G., Krishnan, Suma, Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, De Clercq, Erik, Arnold, Edward, Janssen, Paul A.J.

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Piperazinylalkyl Heterocycles as Potential Antipsychotic Agents von Scott, Malcolm K, Baxter, Ellen W, Bennett, Debra J, Boyd, Robert E, Blum, Paul S, Codd, Ellen E, Kukla, Michael J, Malloy, Elizabeth, Maryanoff, Bruce E

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Synthesis and Anti-HIV-1 Activity of 4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) Derivatives. 3 von Breslin, Henry J, Kukla, Michael J, Ludovici, Donald W, Mohrbacher, Richard, Ho, Winston, Miranda, Milton, Rodgers, James D, Hitchens, T. Kevin, Leo, Gregory

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Pyrrole Mannich bases as potential antipsychotic agents von Scott, Malcolm K, Martin, Gregory E, DiStefano, Deena L, Fedde, Cynthia L, Kukla, Michael J, Barrett, Donna L, Baldy, William J, Elgin, Robert J, Kesslick, James M

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Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Hi... von Das, Kalyan, Clark, Arthur D, Lewi, Paul J, Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Vinkers, H. Maarten, Daeyaert, Frederik, Ludovici, Donald W, Kukla, Michael J, De Corte, Bart, Kavash, Robert W, Ho, Chih Y, Ye, Hong, Lichtenstein, Mark. A, Andries, Koen, Pauwels, Rudi, de Béthune, Marie-Pierre, Boyer, Paul L, Clark, Patrick, Hughes, Stephen H, Janssen, Paul A. J, Arnold, Eddy

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Novel antifungals based on 4-substituted imidazole: A combinatorial chemistry approach to lead discovery and optimization von Saha, Ashis K, Liu, Li, Simoneaux, Richard L, Kukla, Michael J, Marichal, Patrick, Odds, Frank

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Synthesis and Anti-HIV-1 Activity of 4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TlBO) Derivatives. 4 von Ho, Winston, Kukla, Michael J, Breslin, Henry J, Ludovici, Donald W, Grous, Philip P, Diamond, Craig J, Miranda, Milton, Rodgers, James D, Ho, Chih Y

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A novel series of N-(1-aminoalkylidene)carboximidamides as potential hypoglycemic agents von BRESLIN, H. J, KUKLA, M. J, TUMAN, R. W, REBARCHAK, M. C, BOWDEN, C. R

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Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-o... von Breslin, Henry J., Kukla, Michael J., Kromis, Teresa, Cullis, Heather, De Knaep, Fons, Pauwels, Rudi, Andries, Koen, De Clercq, Erik, Janssen, Marcel A.C., Janssen, Paul A.J.

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Antihypertensive dihydropyridines with 1,4,4-trisubstitution von Kukla, Michael J, Breslin, Henry J, Gill, Alan

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Novel triazole based inhibitors of Ras farnesyl transferase von Saha, Ashis K., Liu, Li, Simoneaux, Richard, DeCorte, Bart, Meyer, Christophe, Skrzat, Stacy, Breslin, Henry J., Kukla, Michael J., End, Dave W.

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Synthesis, characterization, and anorectic testing of the four stereoisomers of cyclo(histidylproline) von Kukla, Michael J, Breslin, Henry J, Bowden, Charles R

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Tripeptidyl-peptidase II (TPP II) inhibitory activity of (S)-2,3-dihydro-2-(1H-imidazol-2-yl)-1H-indoles, a systematic SAR evaluation. Part 2 von BRESLIN, Henry J, MISKOWSKI, Tamara A, KUKLA, Michael J, DE WINTER, Hans L, SOMERS, Maria V. F, ROEVENS, Peter W. M, KAVASH, Robert W

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Polycyclic heterocycles from glutaraldehyde in one reaction von Kukla, Michael J, Breslin, Henry J

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Conformational analysis of the reverse transcriptase inhibitor (+)-(S)-4,5,6,7-tetrahydroimidazo-9-chloro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-... von Caldwell, Gary W., Gauthier, A.Diane, Leo, Gregory C., Kukla, Michael J.

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