Affinity improvement of a therapeutic antibody by structure-based computational design: generation of electrostatic interactions in the transition state stabilizes the antibody-ant... von Kiyoshi, Masato, Caaveiro, Jose M M, Miura, Eri, Nagatoishi, Satoru, Nakakido, Makoto, Soga, Shinji, Shirai, Hiroki, Kawabata, Shigeki, Tsumoto, Kouhei

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Structural analysis of Fc/FcγR complexes: a blueprint for antibody design von Caaveiro, Jose M. M., Kiyoshi, Masato, Tsumoto, Kouhei

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Selective and reversible modification of kinase cysteines with chlorofluoroacetamides von Shindo, Naoya, Fuchida, Hirokazu, Sato, Mami, Watari, Kosuke, Shibata, Tomohiro, Kuwata, Keiko, Miura, Chizuru, Okamoto, Kei, Hatsuyama, Yuji, Tokunaga, Keisuke, Sakamoto, Seiichi, Morimoto, Satoshi, Abe, Yoshito, Shiroishi, Mitsunori, Caaveiro, Jose M. M., Ueda, Tadashi, Tamura, Tomonori, Matsunaga, Naoya, Nakao, Takaharu, Koyanagi, Satoru, Ohdo, Shigehiro, Yamaguchi, Yasuchika, Hamachi, Itaru, Ono, Mayumi, Ojida, Akio

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Molecular basis for thermal stability and affinity in a VHH: Contribution of the framework region and its influence in the conformation of the CDR3 von Kinoshita, Seisho, Nakakido, Makoto, Mori, Chinatsu, Kuroda, Daisuke, Caaveiro, Jose M.M., Tsumoto, Kouhei

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Structural basis for the recognition of human hemoglobin by the heme-acquisition protein Shr from Streptococcus pyogenes von Senoo, Akinobu, Hoshino, Masato, Shiomi, Toshiki, Nakakido, Makoto, Nagatoishi, Satoru, Kuroda, Daisuke, Nakagawa, Ichiro, Tame, Jeremy R. H., Caaveiro, Jose M. M., Tsumoto, Kouhei

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Glycosylation of IgG-Fc: a molecular perspective von Kiyoshi, Masato, Tsumoto, Kouhei, Ishii-Watabe, Akiko, Caaveiro, Jose M M

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Discovery and Optimization of Inhibitors of the Parkinson’s Disease Associated Protein DJ‑1 von Tashiro, Shinya, Caaveiro, Jose M. M, Nakakido, Makoto, Tanabe, Aki, Nagatoishi, Satoru, Tamura, Yasushi, Matsuda, Noriyuki, Liu, Dali, Hoang, Quyen Q, Tsumoto, Kouhei

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Bidirectional Transformation of a Metamorphic Protein between the Water-Soluble and Transmembrane Native States von Tanaka, Koji, Caaveiro, Jose M. M, Tsumoto, Kouhei

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Tyrosine Sulfation Restricts the Conformational Ensemble of a Flexible Peptide, Strengthening the Binding Affinity for an Antibody von Miyanabe, Kazuhiro, Yamashita, Takefumi, Abe, Yoshito, Akiba, Hiroki, Takamatsu, Yuichiro, Nakakido, Makoto, Hamakubo, Takao, Ueda, Tadashi, Caaveiro, Jose M. M, Tsumoto, Kouhei

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Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease von Hirose, Yuya, Shindo, Naoya, Mori, Makiko, Onitsuka, Satsuki, Isogai, Hikaru, Hamada, Rui, Hiramoto, Tadanari, Ochi, Jinta, Takahashi, Daisuke, Ueda, Tadashi, Caaveiro, Jose M. M., Yoshida, Yuya, Ohdo, Shigehiro, Matsunaga, Naoya, Toba, Shinsuke, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi, Sato, Akihiko, Kawanishi, Eiji, Ojida, Akio

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Haemolytic actinoporins interact with carbohydrates using their lipid-binding module von Tanaka, Koji, Caaveiro, Jose M. M., Morante, Koldo, Tsumoto, Kouhei

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Differential Effect of Membrane Composition on the Pore-Forming Ability of Four Different Sea Anemone Actinoporins von García-Linares, Sara, Rivera-de-Torre, Esperanza, Morante, Koldo, Tsumoto, Kouhei, Caaveiro, Jose M. M, Gavilanes, José G, Slotte, J. Peter, Martínez-del-Pozo, Álvaro

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Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10 von Rujas, Edurne, Gulzar, Naveed, Morante, Koldo, Tsumoto, Kouhei, Scott, Jamie K, Nieva, José L, Caaveiro, Jose M M

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Epitope-dependent thermodynamic signature of single-domain antibodies against hen egg lysozyme von Akiba, Hiroki, Tamura, Hiroko, Caaveiro, Jose M M, Tsumoto, Kouhei

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Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope von Torralba, Johana, de la Arada, Igor, Partida-Hanon, Angélica, Rujas, Edurne, Arribas, Madalen, Insausti, Sara, Valotteau, Claire, Valle, Javier, Andreu, David, Caaveiro, José M. M., Jiménez, María Angeles, Apellániz, Beatriz, Redondo-Morata, Lorena, Nieva, José L.

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Computer-guided library generation applied to the optimization of single-domain antibodies von Akiba, Hiroki, Tamura, Hiroko, Caaveiro, Jose M M, Tsumoto, Kouhei

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Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1 von Queliconi, Bruno Barros, Kojima, Waka, Kimura, Mayumi, Imai, Kenichiro, Udagawa, Chisato, Motono, Chie, Hirokawa, Takatsugu, Tashiro, Shinya, Caaveiro, Jose M. M., Tsumoto, Kouhei, Yamano, Koji, Tanaka, Keiji, Matsuda, Noriyuki

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New pharmacological effect of fulvestrant to prevent oxaliplatin‐induced neurodegeneration and mechanical allodynia in rats von Yamamoto, Shota, Yamashita, Tomohiro, Ito, Mayu, Caaveiro, Jose M.M., Egashira, Nobuaki, Tozaki‐Saitoh, Hidetoshi, Tsuda, Makoto

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Ca2+‐induced structural changes and intramolecular interactions in N‐terminal region of diacylglycerol kinase alpha von Takahashi, Daisuke, Yonezawa, Kento, Okizaki, Yuki, Caaveiro, Jose M. M., Ueda, Tadashi, Shimada, Atsushi, Sakane, Fumio, Shimizu, Nobutaka

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Heme Binding Mechanism of Structurally Similar Iron-Regulated Surface Determinant Near Transporter Domains of Staphylococcus aureus Exhibiting Different Affinities for Heme von Moriwaki, Yoshitaka, Terada, Tohru, Caaveiro, Jose M. M, Takaoka, Yousuke, Hamachi, Itaru, Tsumoto, Kouhei, Shimizu, Kentaro

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