Cross‐Ancestry Genome‐Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations von Khor, Chiea Chuen, Winter, Stefan, Sutiman, Natalia, Mürdter, Thomas E., Chen, Sylvia, Lim, Joanne Siok Liu, Li, Zheng, Li, Jingmei, Sim, Kar Seng, Ganchev, Boian, Eccles, Diana, Eccles, Bryony, Tapper, William, Zgheib, Nathalie K., Tfayli, Arafat, Ng, Raymond Chee Hui, Yap, Yoon Sim, Lim, Elaine, Wong, Mabel, Wong, Nan Soon, Ang, Peter Cher Siang, Dent, Rebecca, Tremmel, Roman, Klein, Kathrin, Schaeffeler, Elke, Zhou, Yitian, Lauschke, Volker M., Eichelbaum, Michel, Schwab, Matthias, Brauch, Hiltrud B., Chowbay, Balram, Schroth, Werner

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Activity Levels of Tamoxifen Metabolites at the Estrogen Receptor and the Impact of Genetic Polymorphisms of Phase I and II Enzymes on Their Concentration Levels in Plasma von Mürdter, TE, Schroth, W, Bacchus‐Gerybadze, L, Winter, S, Heinkele, G, Simon, W, Fasching, PA, Fehm, T, Eichelbaum, M, Schwab, M, Brauch, H

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Short term culture of breast cancer tissues to study the activity of the anticancer drug taxol in an intact tumor environment von van der Kuip, Heiko, Mürdter, Thomas E, Sonnenberg, Maike, McClellan, Monika, Gutzeit, Susanne, Gerteis, Andreas, Simon, Wolfgang, Fritz, Peter, Aulitzky, Walter E

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The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z‐4‐hydroxy‐tamoxifen in human liver von Coller, Janet K., Krebsfaenger, Niels, Klein, Kathrin, Endrizzi, Karin, Wolbold, Renzo, Lang, Thomas, Nüssler, Andreas, Neuhaus, Peter, Zanger, Ulrich M., Eichelbaum, Michel, Mürdter, Thomas E.

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Microsomal Epoxide Hydrolase Expression as a Predictor of Tamoxifen Response in Primary Breast Cancer: A Retrospective Exploratory Study With Long-Term Follow-Up von FRITZ, Peter, MÜRDTER, Thomas E, EICHELBAUM, Michel, SIEGLE, Isabel, WEISSERT, Matthias, ZANGER, Ulrich M

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Genetic polymorphisms of glutathione S-transferase A1, the major glutathione S-transferase in human liver: Consequences for enzyme expression and busulfan conjugation von Bredschneider, Monika, Klein, Kathrin, Mürdter, Thomas E., Marx, Claudia, Eichelbaum, Michel, Nüssler, Andreas K., Neuhaus, Peter, Zanger, Ulrich M., Schwab, Matthias

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Optimization of the TRAP assay to evaluate specificity of telomerase inhibitors von PIOTROWSKA, Kamilla, KLEIDEITER, Elke, MÜRDTER, Thomas E, TAETZ, Sebastian, BALDES, Christiane, SCHAEFER, Ulrich, LEHR, Claus-Michael, KLOTZ, Ulrich

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Large interindividual variability in the in vitro formation of tamoxifen metabolites related to the development of genotoxicity von Coller, Janet K., Krebsfaenger, Niels, Klein, Kathrin, Wolbold, Renzo, Nüssler, Andreas, Neuhaus, Peter, Zanger, Ulrich M., Eichelbaum, Michel, Mürdter, Thomas E.

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Simple and sensitive method for the determination of celecoxib in human serum by high-performance liquid chromatography with fluorescence detection von Schönberger, Frank, Heinkele, Georg, Mürdter, Thomas E, Brenner, Stefanie, Klotz, Ulrich, Hofmann, Ute

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Enhanced uptake of doxorubicin into bronchial carcinoma : β-glucuronidase mediates release of doxorubicin from a glucuronide prodrug (HMR 1826) at the tumor site von MÜRDTER, T. E, SPERKER, B, KROEMER, H. K, KIVISTÖ, K. T, MCCLELLAN, M, FRITZ, P, FRIEDEL, G, LINDER, A, BOSSLET, K, TOOMES, H, DIERKESMANN, R

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Induction of Metallothionein in Proximal Tubular Cells by Zinc and Its Potential as an Endogenous Antioxidant von Alscher, Dominik M., Braun, Nico, Biegger, Dagmar, Stuelten, Christina, Gawronski, Kerstin, Mürdter, Thomas E., Kuhlmann, Ulrich, Fritz, Peter

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Expression and function of beta-glucuronidase in pancreatic cancer: potential role in drug targeting von Sperker, B, Werner, U, Mürdter, T E, Tekkaya, C, Fritz, P, Wacke, R, Adam, U, Gerken, M, Drewelow, B, Kroemer, H K

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Population pharmacokinetics of oral busulfan in children von SCHILTMEYER, Brunhild, KLINGEBIEL, Thomas, HEMPEL, Georg, SCHWAB, Matthias, MÜRDTER, Thomas E, RITTER, Christoph A, JENKE, Andreas, EHNINGER, Gerhard, GRUHN, Bernd, WÜRTHWEIN, Gudrun, BOOS, Joachim

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Impact of Mistletoe Lectin Binding in Breast Cancer von FRITZ, Peter, DIPPON, Jürgen, KIERSCHKE, Thomas, SIEGLE, Isabel, MÖHRING, Alexandra, MOISA, Adina, MÜRDTER, Thomas E

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Synthesis of [2H]-labelled phase-I-metabolites using 1-[2H]-pyridinium hydrochloride von Heinkele, Georg, Mürdter, Thomas E.

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Sensitive method for the quantification of urinary pyrimidine metabolites in healthy adults by gas chromatography–tandem mass spectrometry von Hofmann, Ute, Schwab, Matthias, Seefried, Sonja, Marx, Claudia, Zanger, Ulrich M., Eichelbaum, Michel, Mürdter, Thomas E.

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Distribution of microsomal epoxide hydrolase in humans: an immunohistochemical study in normal tissues, and benign and malignant tumours von Coller, J K, Fritz, P, Zanger, U M, Siegle, I, Eichelbaum, M, Kroemer, H K, Mürdter, T E

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Expression of active human β-glucuronidase in Sf9 cells infected with recombinant baculovirus von Sperker, Bernhard, Mürdter, Thomas E, Backman, Janne T, Fritz, Peter, Kroemer, Heyo K

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V79 Chinese hamster cells genetically engineered for polymorphic cytochrome P450 2D6 and their predictive value for humans von Krebsfaenger, Niels, Mürdter, Thomas E, Zanger, Ulrich M, Eichelbaum, Michel F, Doehmer, Johannes

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Simultaneous high-performance liquid chromatographic determination of a glucuronyl prodrug of doxorubicin, doxorubicin and its metabolites in human lung tissue von Mürdter, Thomas E, Sperker, Bernhard, Bosslet, Klaus, Fritz, Peter, Kroemer, Heyo K

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