Loss of ATRX/DAXX expression and alternative lengthening of telomeres in uterine leiomyomas von Ahvenainen, Terhi V., Mäkinen, Netta M., von Nandelstadh, Pernilla, Vahteristo, Maija E. A., Pasanen, Annukka M., Bützow, Ralf C., Vahteristo, Pia M.

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Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers von Mehine, Miika, Kaasinen, Eevi, Heinonen, Hanna-Riikka, Mäkinen, Netta, Kämpjärvi, Kati, Sarvilinna, Nanna, Aavikko, Mervi, Vähärautio, Anna, Pasanen, Annukka, Bützow, Ralf, Heikinheimo, Oskari, Sjöberg, Jari, Pitkänen, Esa, Vahteristo, Pia, Aaltonen, Lauri A.

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Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12 von Mäkinen, Netta, Aavikko, Mervi, Heikkinen, Tuomas, Taipale, Minna, Taipale, Jussi, Koivisto-Korander, Riitta, Bützow, Ralf, Vahteristo, Pia

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Exome-wide somatic mutation characterization of small bowel adenocarcinoma von Hänninen, Ulrika A, Katainen, Riku, Tanskanen, Tomas, Plaketti, Roosa-Maria, Laine, Riku, Hamberg, Jiri, Ristimäki, Ari, Pukkala, Eero, Taipale, Minna, Mecklin, Jukka-Pekka, Forsström, Linda M, Pitkänen, Esa, Palin, Kimmo, Välimäki, Niko, Mäkinen, Netta, Aaltonen, Lauri A

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Parity associates with chromosomal damage in uterine leiomyomas von Kuisma, Heli, Bramante, Simona, Rajamäki, Kristiina, Sipilä, Lauri J., Kaasinen, Eevi, Kaukomaa, Jaana, Palin, Kimmo, Mäkinen, Netta, Sjöberg, Jari, Sarvilinna, Nanna, Taipale, Jussi, Kauppi, Liisa, Tumiati, Manuela, Hassinen, Antti, Pitkäniemi, Janne, Jalkanen, Jyrki, Heikkinen, Sanna, Pasanen, Annukka, Heikinheimo, Oskari, Bützow, Ralf, Välimäki, Niko, Aaltonen, Lauri A.

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MED12, the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas von MÄKINEN, Netta, MEHINE, Miika, AAVIKKO, Mervi, KATAINEN, Riku, VIROLAINEN, Elina, BÖHLING, Tom, KOSKI, Taru A, LAUNONEN, Virpi, SJÖBERG, Jari, TAIPALE, Jussi, VAHTERISTO, Pia, AALTONEN, Lauri A, TOLVANEN, Jaana, KAASINEN, Eevi, YILONG LI, LEHTONEN, Heli J, GENTILE, Massimiliano, JIAN YAN, ENGE, Martin, TAIPALE, Minna

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Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity von Turunen, Mikko, Spaeth, Jason M., Keskitalo, Salla, Park, Min Ju, Kivioja, Teemu, Clark, Alison D., Mäkinen, Netta, Gao, Fangjian, Palin, Kimmo, Nurkkala, Helka, Vähärautio, Anna, Aavikko, Mervi, Kämpjärvi, Kati, Vahteristo, Pia, Kim, Chongwoo A., Aaltonen, Lauri A., Varjosalo, Markku, Taipale, Jussi, Boyer, Thomas G.

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MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas von Kämpjärvi, Kati, Mäkinen, Netta, Mehine, Miika, Välipakka, Salla, Uimari, Outi, Pitkänen, Esa, Heinonen, Hanna-Riikka, Heikkinen, Tuomas, Tolvanen, Jaana, Ahtikoski, Anne, Frizzell, Norma, Sarvilinna, Nanna, Sjöberg, Jari, Bützow, Ralf, Aaltonen, Lauri A, Vahteristo, Pia

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Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma von Berta, Davide G., Kuisma, Heli, Välimäki, Niko, Räisänen, Maritta, Jäntti, Maija, Pasanen, Annukka, Karhu, Auli, Kaukomaa, Jaana, Taira, Aurora, Cajuso, Tatiana, Nieminen, Sanna, Penttinen, Rosa-Maria, Ahonen, Saija, Lehtonen, Rainer, Mehine, Miika, Vahteristo, Pia, Jalkanen, Jyrki, Sahu, Biswajyoti, Ravantti, Janne, Mäkinen, Netta, Rajamäki, Kristiina, Palin, Kimmo, Taipale, Jussi, Heikinheimo, Oskari, Bützow, Ralf, Kaasinen, Eevi, Aaltonen, Lauri A.

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MED12 exon 2 mutations are common in uterine leiomyomas from South African patients von Mäkinen, Netta, Heinonen, Hanna-Riikka, Moore, Shane, Tomlinson, Ian P M, van der Spuy, Zephne M, Aaltonen, Lauri A

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Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers von Hänninen, Ulrika A., Wirta, Erkki-Ville, Katainen, Riku, Tanskanen, Tomas, Hamberg, Jiri, Taipale, Minna, Böhm, Jan, Renkonen-Sinisalo, Laura, Lepistö, Anna, Forsström, Linda M., Pitkänen, Esa, Palin, Kimmo, Seppälä, Toni T., Mäkinen, Netta, Mecklin, Jukka-Pekka, Aaltonen, Lauri A.

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Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms von Kämpjärvi, Kati, Kim, Nam Hee, Keskitalo, Salla, Clark, Alison D., von Nandelstadh, Pernilla, Turunen, Mikko, Heikkinen, Tuomas, Park, Min Ju, Mäkinen, Netta, Kivinummi, Kati, Lintula, Susanna, Hotakainen, Kristina, Nevanlinna, Heli, Hokland, Peter, Böhling, Tom, Bützow, Ralf, Böhm, Jan, Mecklin, Jukka-Pekka, Järvinen, Heikki, Kontro, Mika, Visakorpi, Tapio, Taipale, Jussi, Varjosalo, Markku, Boyer, Thomas G., Vahteristo, Pia

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Global metabolomic profiling of uterine leiomyomas von Heinonen, Hanna-Riikka, Mehine, Miika, Mäkinen, Netta, Pasanen, Annukka, Pitkänen, Esa, Karhu, Auli, Sarvilinna, Nanna S, Sjöberg, Jari, Heikinheimo, Oskari, Bützow, Ralf, Aaltonen, Lauri A, Kaasinen, Eevi

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Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry von Heikkinen, Tuomas, Kämpjärvi, Kati, Keskitalo, Salla, von Nandelstadh, Pernilla, Liu, Xiaonan, Rantanen, Ville, Pitkänen, Esa, Kinnunen, Matias, Kuusanmäki, Heikki, Kontro, Mika, Turunen, Mikko, Mäkinen, Netta, Taipale, Jussi, Heckman, Caroline, Lehti, Kaisa, Mustjoki, Satu, Varjosalo, Markku, Vahteristo, Pia

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Genomic Evolution in a Patient With Lung Adenocarcinoma With a Germline EGFR T790M Mutation von Mäkinen, Netta, Zhou, Meng, Bemus, Meredith, Nevin, Julius, Nag, Anwesha, Chen, Ruthia, Colson, Yolonda L., Thorner, Aaron R., Oxnard, Geoffrey R., Meyerson, Matthew, Sholl, Lynette M.

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The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution von Rood, Jennifer E., Coffey, Robert J., Demir, Emek, Ghosh, Sharmistha, Iacobuzio-Donahue, Christine A., Jané-Valbuena, Judit, Mazzilli, Sarah A., Pe’er, Dana, Tan, Kai, Aguilar, Ruben A., Babur, Ozgun, Boland, Genevieve, Bosse, Kristopher, Bott, Matthew, Boyden, Ed, Brooks, James, Cerami, Ethan, Chang, Young Hwan, Chaudhary, Ojasvi, Chen, Alyce A., Chen, Feng, Chun, Jaeyoung, Cisneros, Luis, Contrepois, Kevin, Creason, Allison L., Demir, Emek, Diskin, Sharon, Drewes, Julia, Eng, Jennifer, Erwin, Graham, Flaherty, Keith, Gao, Jianjiong, Gao, Vianne R., Giannakis, Marios, Gowers, Kate, Gray, Joe W., Greenleaf, William, Gresham, Jeremy, Hacohen, Nir, Harris, Kathleen A., Hayashi, Akimasa, Herndon, John M., Huh, Won Jae, Ijaz, Heba, Izar, Benjamin, Johnson, Brett E., Kaestner, Klaus, Kim, Albert H., Kopytra, Mateusz, Kundaje, Anshul, Lau, Ken S., Lee, Hayan, Lenburg, Marc, Lim, Kian-Huat, Lin, Yiyun, Lively, Tracy, Longabaugh, William J.R., Ma, Cynthia X., Marks, Jeffrey, Masilionais, Ignas, McKinley, Eliot T., McMichael, Joshua F., Mosse, Yael, Ness, Reid, Nikolov, Milen, Oberdoerffer, Philipp, Offin, Michael, Olson, Anastasiya, Ossandon, Miguel, Polyak, Kornelia, Reid, Mary, Roy, Sudipta, Ryser, Marc D., Schrag, Deborah, Sears, Rosalie C., Shalek, Alex, Sheng, Jeff, Shoghi, Kooresh I., Sibley, Alexander B., Sorger, Peter K., Southard-Smith, Austin, Srivastava, Sudhir, Storm, Phillip, Sullivan, Ryan, Suvà, Mario, Thorsson, Vésteinn, Tran, Linh, Veis, Deborah J., Vossough, Arastoo, Wagle, Nikhil, Wang, Liang-Bo, West, Robert, Wu, Chi-yun, Wyczalkowski, Matthew A., Xie, Yubin, Yang, Xiaolu, Zhang, Mianlei, Zhang, Yantian, Zhou, Daniel Cui, Zhuang, Xiaowei

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Abstract LB-382: Identification of predisposing genes for small bowel adenocarcinoma by exome sequencing von Hänninen, Ulrika A., Katainen, Riku, Tanskanen, Tomas, Hamberg, Jiri, Ristimäki, Ari, Pukkala, Eero, Taipale, Minna, Mecklin, Jukka-Pekka, Aavikko, Mervi, Forsström, Linda M., Pitkänen, Esa, Mäkinen, Netta, Aaltonen, Lauri A.

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