RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis von Brünker, Peter, Wartha, Katharina, Friess, Thomas, Grau-Richards, Sandra, Waldhauer, Inja, Koller, Claudia Ferrara, Weiser, Barbara, Majety, Meher, Runza, Valeria, Niu, Huifeng, Packman, Kathryn, Feng, Ningping, Daouti, Sherif, Hosse, Ralf J, Mössner, Ekkehard, Weber, Thomas G, Herting, Frank, Scheuer, Werner, Sade, Hadassah, Shao, Cuiying, Liu, Bin, Wang, Peng, Xu, Gary, Vega-Harring, Suzana, Klein, Christian, Bosslet, Klaus, Umaña, Pablo

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GA101 P329GLALA, a variant of obinutuzumab with abolished ADCC, ADCP and CDC function but retained cell death induction, is as efficient as rituximab in B-cell depletion and antitu... von Herter, Sylvia, Herting, Frank, Muth, Gunter, van Puijenbroek, Erwin, Schlothauer, Tilman, Ferrara, Claudia, Brady, Kevin, Lang, Sabine, Bacac, Marina, Mössner, Ekkehard, Umana, Pablo, Klein, Christian

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CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins von Jost, Christian, Darowski, Diana, Challier, John, Pulko, Vesna, Hanisch, Lydia J, Xu, Wei, Mössner, Ekkehard, Bujotzek, Alexander, Klostermann, Stefan, Umana, Pablo, Kontermann, Roland E, Klein, Christian

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Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions von Schlothauer, Tilman, Herter, Sylvia, Koller, Claudia Ferrara, Grau-Richards, Sandra, Steinhart, Virginie, Spick, Christian, Kubbies, Manfred, Klein, Christian, Umaña, Pablo, Mössner, Ekkehard

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Characterization of Escherichia coli thioredoxin variants mimicking the active‐sites of other thiol/disulfide oxidoreductases von Mössner, Ekkehard, Huber‐Wunderlich, Martina, Glockshuber, Rudi

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Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties von Klein, Christian, Lammens, Alfred, Schäfer, Wolfgang, Georges, Guy, Schwaiger, Manfred, Mössner, Ekkehard, Hopfner, Karl-Peter, Umaña, Pablo, Niederfellner, Gerhard

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Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell–mediated B-cell cytotoxic... von Mössner, Ekkehard, Brünker, Peter, Moser, Samuel, Püntener, Ursula, Schmidt, Carla, Herter, Sylvia, Grau, Roger, Gerdes, Christian, Nopora, Adam, van Puijenbroek, Erwin, Ferrara, Claudia, Sondermann, Peter, Jäger, Christiane, Strein, Pamela, Fertig, Georg, Friess, Thomas, Schüll, Christine, Bauer, Sabine, Dal Porto, Joseph, Del Nagro, Christopher, Dabbagh, Karim, Dyer, Martin J.S., Poppema, Sibrand, Klein, Christian, Umaña, Pablo

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Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies von Niederfellner, Gerhard, Lammens, Alfred, Mundigl, Olaf, Georges, Guy J., Schaefer, Wolfgang, Schwaiger, Manfred, Franke, Andreas, Wiechmann, Kornelius, Jenewein, Stefan, Slootstra, Jerry W., Timmerman, Peter, Brännström, Annika, Lindstrom, Frida, Mössner, Ekkehard, Umana, Pablo, Hopfner, Karl-Peter, Klein, Christian

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Complementation of DsbA deficiency with secreted thioredoxin variants reveals the crucial role of an efficient dithiol oxidant for catalyzed protein folding in the bacterial peripl... von Jonda, Silke, Huber-Wunderlich, Martina, Glockshuber, Rudi, Mössner, Ekkehard

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Biochemical and biophysical characterization of purified native CD20 alone and in complex with rituximab and obinutuzumab von Agez, Morgane, Mandon, Elodie Desuzinges, Iwema, Thomas, Gianotti, Reto, Limani, Florian, Herter, Sylvia, Mössner, Ekkehard, Kusznir, Eric A., Huber, Sylwia, Lauer, Matthias, Ringler, Philippe, Ferrara, Claudia, Klein, Christian, Jawhari, Anass

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P329G-CAR-J: a novel Jurkat-NFAT-based CAR-T reporter system recognizing the P329G Fc mutation von Darowski, Diana, Jost, Christian, Stubenrauch, Kay, Wessels, Uwe, Benz, Jörg, Ehler, Andreas, Freimoser-Grundschober, Anne, Brünker, Peter, Mössner, Ekkehard, Umaña, Pablo, Kobold, Sebastian, Klein, Christian

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Abstract 4229: Anti-P329G-CAR-T cells as a novel universal CAR-T cell platform von Darowski, Diana, Jost, Christian, Riester, Zeno, Benmebarek, Mohamed, Stubenrauch, Kay, Freimoser-Grundschober, Anne, Wessels, Uwe, Benz, Jörg, Mössner, Ekkehard, Myburgh, Renier, Cremasco, Floriana, Perro, Mario, Umana, Pablo, Kobold, Sebastian, Klein, Christian

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Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional I... von Klein, Christian, Waldhauer, Inja, Nicolini, Valeria G., Freimoser-Grundschober, Anne, Nayak, Tapan, Vugts, Danielle J., Dunn, Claire, Bolijn, Marije, Benz, Jörg, Stihle, Martine, Lang, Sabine, Roemmele, Michaele, Hofer, Thomas, van Puijenbroek, Erwin, Wittig, David, Moser, Samuel, Ast, Oliver, Brünker, Peter, Gorr, Ingo H., Neumann, Sebastian, de Vera Mudry, Maria Cristina, Hinton, Heather, Crameri, Flavio, Saro, Jose, Evers, Stefan, Gerdes, Christian, Bacac, Marina, van Dongen, Guus, Moessner, Ekkehard, Umaña, Pablo

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ANTIGEN BINDING MOLECULES WITH INCREASED FC RECEPTOR BINDING AFFINITY AND EFFECTOR FUNCTION von SUTER, Tobias, BRÚNKER, Peter, MÓSSNER, Ekkehard, FERRARA KOLLER, Claudia, UMAÑA, Pablo, PÚNTENER, Ursula

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Abstract 3629: Engineering a novel asymmetric head-to-tail 2+1 T-cell bispecific (2+1 TCB) IgG antibody platform with superior T-cell killing compared to 1+1 asymmetric TCBs von Klein, Christian, Neumann, Christiane, Fauti, Tanja, Weinzierl, Tina, Freimoser-Grundschober, Anne, Waldhauer, Inja, Fahrni, Linda, Herter, Sylvia, Puijenbroek, Erwin van, Colombetti, Sara, Sam, Johannes, Lang, Sabine, Dudal, Sherri, Schäfer, Wolfgang, Regula, Jörg T., Moser, Samuel, Ast, Oliver, Hosse, Ralf, Mössner, Ekkehard, Brünker, Peter, Bacac, Marina, Umana, Pablo

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ANTIGEN BINDING MOLECULES WITH INCREASED FC RECEPTOR BINDING AFFINITY AND EFFECTOR FUNCTION von Brúnker, Peter, UMAÑA, Pablo, Ferrara Koller, Claudia, Púntener, Ursula, Móssner, Ekkehard, Suter, Tobias

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Directed Evolution with Fast and Efficient Selection Technologies von Mössner, Ekkehard, Plückthun, Andreas

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A New Class of T-Cell Bispecific Antibodies for the Treatment of Multiple Myeloma, Binding to B Cell Maturation Antigen and CD3 and Showing Potent, Specific Antitumor Activity in M... von Vu, Minh Diem, Moser, Samuel, Delon, Camille, Latzko, Melanie, Gianotti, Reto, Lüoend, Remo, Friang, Chloé, Murr, Ramona, Duerner, Lydia Jasmin, Weinzierl, Tina, Fauti, Tanja, Bacac, Marina, Ast, Oliver, Freimoser-Grundschober, Anne, Rodriguez Diaz, Tea, Zielonka, Jörg, van Puijenbroek, Erwin, Hosse, Ralf, Bruenker, Peter, Mössner, Ekkehard, Klein, Christian, Umaña, Pablo, Strein, Klaus

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Response to: Monoclonal antibodies targeting CD20 von Klein, Christian, Lammens, Alfred, Schäfer, Wolfgang, Georges, Guy, Schwaiger, Manfred, Mössner, Ekkehard, Hopfner, Karl-Peter, Umaña, Pablo, Niederfellner, Gerhard

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Influence of the pK a value of the buried, active‐site cysteine on the redox properties of thioredoxin‐like oxidoreductases von Mössner, Ekkehard, Iwai, Hideo, Glockshuber, Rudi

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