Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway von Ollila, Saara, Domènech-Moreno, Eva, Laajanen, Kaisa, Wong, Iris Pl, Tripathi, Sushil, Pentinmikko, Nalle, Gao, Yajing, Yan, Yan, Niemelä, Elina H, Wang, Timothy C, Viollet, Benoit, Leone, Gustavo, Katajisto, Pekka, Vaahtomeri, Kari, Mäkelä, Tomi P

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CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner von Yang, Ying, Roine, Niina, Mäkelä, Tomi P

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Inactivation of AMPK Leads to Attenuation of Antigen Presentation and Immune Evasion in Lung Adenocarcinoma von Gao, Yajing, Päivinen, Pekka, Tripathi, Sushil, Domènech-Moreno, Eva, Wong, Iris P L, Vaahtomeri, Kari, Nagaraj, Ashwini S, Talwelkar, Sarang S, Foretz, Marc, Verschuren, Emmy W, Viollet, Benoit, Yan, Yan, Mäkelä, Tomi P

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Assembly of non-contractile dorsal stress fibers requires α-actinin-1 and Rac1 in migrating and spreading cells von Kovac, Bianca, Teo, Jessica L, Mäkelä, Tomi P, Vallenius, Tea

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Molecular mechanisms of tumor suppression by LKB1 von Vaahtomeri, Kari, Mäkelä, Tomi P.

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LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate von Gao, Yajing, Yan, Yan, Tripathi, Sushil, Pentinmikko, Nalle, Amaral, Ana, Päivinen, Pekka, Domènech-Moreno, Eva, Andersson, Simon, Wong, Iris P.L., Clevers, Hans, Katajisto, Pekka, Mäkelä, Tomi P.

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Cdk8 Is Essential for Preimplantation Mouse Development von Westerling, Thomas, Kuuluvainen, Emilia, Maäkelaä, Tomi P.

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Increased α-actinin-1 destabilizes E-cadherin-based adhesions and associates with poor prognosis in basal-like breast cancer von Kovac, Bianca, Mäkelä, Tomi P, Vallenius, Tea

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Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity von Partanen, Johanna I., Tervonen, Topi A., Myllynen, Mikko, Lind, Essi, Imai, Misa, Katajisto, Pekka, Dijkgraaf, Gerrit J. P., Kovanen, Panu E., Mäkelä, Tomi P., Werb, Zena, Klefström, Juha

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Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5 von Giri, Anil K., Aavikko, Mervi, Wartiovaara, Linnea, Lemmetyinen, Toni, Karjalainen, Juha, Mehtonen, Juha, Palin, Kimmo, Välimäki, Niko, Tamlander, Max, Saikkonen, Riikka, Karhu, Auli, Morgunova, Ekaterina, Sun, Benjamin, Runz, Heiko, Palta, Priit, Luo, Shuang, Joensuu, Heikki, Mäkelä, Tomi P., Kostiainen, Iiro, Schalin-Jäntti, Camilla, FinnGen, Palotie, Aarno, Aaltonen, Lauri A., Ollila, Saara, Daly, Mark J.

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Mat1 Inhibits Peroxisome Proliferator-Activated Receptor γ-Mediated Adipocyte Differentiation von Helenius, Katja, Yang, Ying, Alasaari, Jukka, Mäkelä, Tomi P.

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 von Lizcano, Jose M, Göransson, Olga, Toth, Rachel, Deak, Maria, Morrice, Nick A, Boudeau, Jérôme, Hawley, Simon A, Udd, Lina, Mäkelä, Tomi P, Hardie, D Grahame, Alessi, Dario R

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Phosphorylated β-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain von Chilov, Dmitri, Sinjushina, Natalia, Rita, Hannu, Taketo, Makoto M., Mäkelä, Tomi P., Partanen, Juha

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Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation von Lemmetyinen, Toni T., Viitala, Emma W., Wartiovaara, Linnea, Päivinen, Pekka, Virtanen, Heikki T., Pentinmikko, Nalle, Katajisto, Pekka, Mäkelä, Tomi P., Wang, Timothy C., Andressoo, Jaan-Olle, Ollila, Saara

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SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling von Yan, Yan, Ollila, Saara, Wong, Iris P. L., Vallenius, Tea, Palvimo, Jorma J., Vaahtomeri, Kari, Mäkelä, Tomi P.

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The tumor suppressor kinase LKB1: lessons from mouse models von Ollila, Saara, Mäkelä, Tomi P.

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AMPK negatively regulates tensin-dependent integrin activity von Georgiadou, Maria, Lilja, Johanna, Jacquemet, Guillaume, Guzmán, Camilo, Rafaeva, Maria, Alibert, Charlotte, Yan, Yan, Sahgal, Pranshu, Lerche, Martina, Manneville, Jean-Baptiste, Mäkelä, Tomi P, Ivaska, Johanna

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Vascular Abnormalities and Deregulation of VEGF in Lkb1-Deficient Mice von Ylikorkala, Antti, Rossi, Derrick J., Korsisaari, Nina, Luukko, Keijo, Alitalo, Kari, Henkemeyer, Mark, Mäkelä, Tomi P.

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Integrated network analysis platform for protein-protein interactions von Wu, Jianmin, Vallenius, Tea, Ovaska, Kristian, Westermarck, Jukka, Mäkelä, Tomi P, Hautaniemi, Sampsa

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Cyclin-dependent Kinase 8 Module Expression Profiling Reveals Requirement of Mediator Subunits 12 and 13 for Transcription of Serpent-dependent Innate Immunity Genes in Drosophila von Kuuluvainen, Emilia, Hakala, Heini, Havula, Essi, Sahal Estimé, Michelle, Rämet, Mika, Hietakangas, Ville, Mäkelä, Tomi P.

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