Abstract 4045: MRAS and SHOC2 interact with SCRIB and coordinate ERK pathway activation with polarity and tumorigenic growth von Young, Lucy C., Hartig, Nicole, Munoz-Alegre, Marta, Oses-Prieto, Juan A., Durdu, Sevi, Bender, Sabine, Vijakumar, Vineetha, Vietri Rudan, Matteo, Gewinner, Christina, Jathoul, Amit P., Ghatrora, Rupinder, Lythgoe, Mark L., Burlingame, Alma L., Rodriguez-Viciana, Pablo

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Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma von Agliardi, Giulia, Liuzzi, Anna Rita, Hotblack, Alastair, De Feo, Donatella, Núñez, Nicolás, Stowe, Cassandra L., Friebel, Ekaterina, Nannini, Francesco, Rindlisbacher, Lukas, Roberts, Thomas A., Ramasawmy, Rajiv, Williams, Iwan P., Siow, Bernard M., Lythgoe, Mark F., Kalber, Tammy L., Quezada, Sergio A., Pule, Martin A., Tugues, Sonia, Straathof, Karin, Becher, Burkhard

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In vivo imaging of glucose uptake and metabolism in tumors von Walker-Samuel, Simon, Ramasawmy, Rajiv, Torrealdea, Francisco, Rega, Marilena, Rajkumar, Vineeth, Johnson, S Peter, Richardson, Simon, Gonçalves, Miguel, Parkes, Harold G, Årstad, Erik, Thomas, David L, Pedley, R Barbara, Lythgoe, Mark F, Golay, Xavier

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Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve von Machhada, Asif, BS, Ang, Richard, MBBS, Ackland, Gareth L., PhD, FRCA, Ninkina, Natalia, PhD, Buchman, Vladimir L., MD, PhD, Lythgoe, Mark F., PhD, Trapp, Stefan, PhD, Tinker, Andrew, MBBS, PhD, FRCP, Marina, Nephtali, MBBS, PhD, Gourine, Alexander V., PhD

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An MRAS, SHOC2, and SCRIB Complex Coordinates ERK Pathway Activation with Polarity and Tumorigenic Growth von Young, Lucy C., Hartig, Nicole, Muñoz-Alegre, Marta, Oses-Prieto, Juan A., Durdu, Sevi, Bender, Sabine, Vijayakumar, Vineetha, Vietri Rudan, Matteo, Gewinner, Christina, Henderson, Stephen, Jathoul, Amit P., Ghatrora, Rupinder, Lythgoe, Mark F., Burlingame, Alma L., Rodriguez-Viciana, Pablo

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Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study von Ohene, Yolanda, Harrison, Ian F., Nahavandi, Payam, Ismail, Ozama, Bird, Eleanor V., Ottersen, Ole P., Nagelhus, Erlend A., Thomas, David L., Lythgoe, Mark F., Wells, Jack A.

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Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI von Harrison, Ian F, Siow, Bernard, Akilo, Aisha B, Evans, Phoebe G, Ismail, Ozama, Ohene, Yolanda, Nahavandi, Payam, Thomas, David L, Lythgoe, Mark F, Wells, Jack A

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Pharmacological MRI with Simultaneous Measurement of Cerebral Perfusion and Blood-Cerebrospinal Fluid Barrier Function using Interleaved Echo-Time Arterial Spin Labelling von Perera, Charith, Harrison, Ian F., Lythgoe, Mark F., Thomas, David L., Wells, Jack A.

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CO2 signaling mediates neurovascular coupling in the cerebral cortex von Hosford, Patrick S., Wells, Jack A., Nizari, Shereen, Christie, Isabel N., Theparambil, Shefeeq M., Castro, Pablo A., Hadjihambi, Anna, Barros, L. Felipe, Ruminot, Iván, Lythgoe, Mark F., Gourine, Alexander V.

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Vagal determinants of exercise capacity von Machhada, Asif, Trapp, Stefan, Marina, Nephtali, Stephens, Robert C.M., Whittle, John, Lythgoe, Mark F., Kasparov, Sergey, Ackland, Gareth L., Gourine, Alexander V.

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Gold–silica quantum rattles for multimodal imaging and therapy von Hembury, Mathew, Chiappini, Ciro, Bertazzo, Sergio, Kalber, Tammy L., Drisko, Glenna L., Ogunlade, Olumide, Walker-Samuel, Simon, Krishna, Katla Sai, Jumeaux, Coline, Beard, Paul, Kumar, Challa S. S. R., Porter, Alexandra E., Lythgoe, Mark F., Boissière, Cédric, Sanchez, Clément, Stevens, Molly M.

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Development of [18F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism von Sander, Kerstin, Gendron, Thibault, Cybulska, Klaudia A, Sirindil, Fatih, Zhou, Junhua, Kalber, Tammy L, Lythgoe, Mark F, Kurzawinski, Tom R, Brown, Morris J, Williams, Bryan, Årstad, Erik

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Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin von Stowe, Cassandra L, Burley, Thomas A, Allan, Helen, Vinci, Maria, Kramer-Marek, Gabriela, Ciobota, Daniela M, Parkinson, Gary N, Southworth, Tara L, Agliardi, Giulia, Hotblack, Alastair, Lythgoe, Mark F, Branchini, Bruce R, Kalber, Tammy L, Anderson, James C, Pule, Martin A

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Hyperthermia treatment of tumors by mesenchymal stem cell-delivered superparamagnetic iron oxide nanoparticles von Kalber, Tammy L, Ordidge, Katherine L, Southern, Paul, Loebinger, Michael R, Kyrtatos, Panagiotis G, Pankhurst, Quentin A, Lythgoe, Mark F, Janes, Sam M

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Sulfonium Salts as Leaving Groups for Aromatic Labelling of Drug-like Small Molecules with Fluorine-18 von Sander, Kerstin, Gendron, Thibault, Yiannaki, Elena, Cybulska, Klaudia, Kalber, Tammy L., Lythgoe, Mark F., Årstad, Erik

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Investigating changes in blood-cerebrospinal fluid barrier function in a rat model of chronic hypertension using non-invasive magnetic resonance imaging von Perera, Charith, Tolomeo, Daniele, Baker, Rebecca R, Ohene, Yolanda, Korsak, Alla, Lythgoe, Mark F, Thomas, David L, Wells, Jack A

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PEGylation improves the receptor-mediated transfection efficiency of peptide-targeted, self-assembling, anionic nanocomplexes von Tagalakis, Aristides D., Kenny, Gavin D., Bienemann, Alison S., McCarthy, David, Munye, Mustafa M., Taylor, Hannah, Wyatt, Marcella J., Lythgoe, Mark F., White, Edward A., Hart, Stephen L.

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Lung delivery of MSCs expressing anti-cancer protein TRAIL visualised with 89Zr-oxine PET-CT von Patrick, P. Stephen, Kolluri, Krishna K., Zaw Thin, May, Edwards, Adam, Sage, Elizabeth K., Sanderson, Tom, Weil, Benjamin D., Dickson, John C., Lythgoe, Mark F., Lowdell, Mark, Janes, Sam M., Kalber, Tammy L.

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Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes von Watkins-Chow, Dawn E, Cooke, Joanna, Pidsley, Ruth, Edwards, Andrew, Slotkin, Rebecca, Leeds, Karen E, Mullen, Raymond, Baxter, Laura L, Campbell, Thomas G, Salzer, Marion C, Biondini, Laura, Gibney, Gretchen, Phan Dinh Tuy, Françoise, Chelly, Jamel, Morris, H Douglas, Riegler, Johannes, Lythgoe, Mark F, Arkell, Ruth M, Loreni, Fabrizio, Flint, Jonathan, Pavan, William J, Keays, David A

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Monitoring the Growth of an Orthotopic Tumour Xenograft Model: Multi-Modal Imaging Assessment with Benchtop MRI (1T), High-Field MRI (9.4T), Ultrasound and Bioluminescence von Ramasawmy, Rajiv, Johnson, S Peter, Roberts, Thomas A, Stuckey, Daniel J, David, Anna L, Pedley, R Barbara, Lythgoe, Mark F, Siow, Bernard, Walker-Samuel, Simon

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