Metabolic Interactions in the Tumor Microenvironment von Lyssiotis, Costas A., Kimmelman, Alec C.

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Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer von Halbrook, Christopher J., Lyssiotis, Costas A.

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Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton von Hu, Hai, Juvekar, Ashish, Lyssiotis, Costas A., Lien, Evan C., Albeck, John G., Oh, Doogie, Varma, Gopal, Hung, Yin Pun, Ullas, Soumya, Lauring, Josh, Seth, Pankaj, Lundquist, Mark R., Tolan, Dean R., Grant, Aaron K., Needleman, Daniel J., Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.

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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect von Yang, Weiwei, Zheng, Yanhua, Xia, Yan, Ji, Haitao, Chen, Xiaomin, Guo, Fang, Lyssiotis, Costas A., Aldape, Kenneth, Cantley, Lewis C., Lu, Zhimin

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Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis von Santana-Codina, Naiara, Roeth, Anjali A., Zhang, Yi, Yang, Annan, Mashadova, Oksana, Asara, John M., Wang, Xiaoxu, Bronson, Roderick T., Lyssiotis, Costas A., Ying, Haoqiang, Kimmelman, Alec C.

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Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer von Lien, Evan C., Lyssiotis, Costas A., Juvekar, Ashish, Hu, Hai, Asara, John M., Cantley, Lewis C., Toker, Alex

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Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer von Halbrook, Christopher J., Pontious, Corbin, Kovalenko, Ilya, Lapienyte, Laura, Dreyer, Stephan, Lee, Ho-Joon, Thurston, Galloway, Zhang, Yaqing, Lazarus, Jenny, Sajjakulnukit, Peter, Hong, Hanna S., Kremer, Daniel M., Nelson, Barbara S., Kemp, Samantha, Zhang, Li, Chang, David, Biankin, Andrew, Shi, Jiaqi, Frankel, Timothy L., Crawford, Howard C., Morton, Jennifer P., Pasca di Magliano, Marina, Lyssiotis, Costas A.

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Nutrient transporters: connecting cancer metabolism to therapeutic opportunities von Nwosu, Zeribe Chike, Song, Mun Gu, di Magliano, Marina Pasca, Lyssiotis, Costas A., Kim, Sung Eun

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Acetate Fuels the Cancer Engine von Lyssiotis, Costas A., Cantley, Lewis C.

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Metabolic Regulation of Redox Balance in Cancer von Purohit, Vinee, Simeone, Diane M, Lyssiotis, Costas A

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NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome von Fang, Evandro F., Hou, Yujun, Lautrup, Sofie, Jensen, Martin Borch, Yang, Beimeng, SenGupta, Tanima, Caponio, Domenica, Khezri, Rojyar, Demarest, Tyler G., Aman, Yahyah, Figueroa, David, Morevati, Marya, Lee, Ho-Joon, Kato, Hisaya, Kassahun, Henok, Lee, Jong-Hyuk, Filippelli, Deborah, Okur, Mustafa Nazir, Mangerich, Aswin, Croteau, Deborah L., Maezawa, Yoshiro, Lyssiotis, Costas A., Tao, Jun, Yokote, Koutaro, Rusten, Tor Erik, Mattson, Mark P., Jasper, Heinrich, Nilsen, Hilde, Bohr, Vilhelm A.

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A regenerative approach to the treatment of multiple sclerosis von Deshmukh, Vishal A., Tardif, Virginie, Lyssiotis, Costas A., Green, Chelsea C., Kerman, Bilal, Kim, Hyung Joon, Padmanabhan, Krishnan, Swoboda, Jonathan G., Ahmad, Insha, Kondo, Toru, Gage, Fred H., Theofilopoulos, Argyrios N., Lawson, Brian R., Schultz, Peter G., Lairson, Luke L.

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Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas von Chung, Chan, Sweha, Stefan R., Pratt, Drew, Tamrazi, Benita, Panwalkar, Pooja, Banda, Adam, Bayliss, Jill, Hawes, Debra, Yang, Fusheng, Lee, Ho-Joon, Shan, Mengrou, Cieslik, Marcin, Qin, Tingting, Werner, Christian K., Wahl, Daniel R., Lyssiotis, Costas A., Bian, Zhiguo, Shotwell, J. Brad, Yadav, Viveka Nand, Koschmann, Carl, Chinnaiyan, Arul M., Blüml, Stefan, Judkins, Alexander R., Venneti, Sriram

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Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers von Mullarky, Edouard, Lucki, Natasha C., Zavareh, Reza Beheshti, Anglin, Justin L., Gomes, Ana P., Nicolay, Brandon N., Wong, Jenny C. Y., Christen, Stefan, Takahashi, Hidenori, Singh, Pradeep K., Blenis, John, Warren, J. David, Fendt, Sarah-Maria, Asara, John M., DeNicola, Gina M., Lyssiotis, Costas A., Lairson, Luke L., Cantley, Lewis C.

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Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism von Ying, Haoqiang, Kimmelman, Alec C., Lyssiotis, Costas A., Hua, Sujun, Chu, Gerald C., Fletcher-Sananikone, Eliot, Locasale, Jason W., Son, Jaekyoung, Zhang, Hailei, Coloff, Jonathan L., Yan, Haiyan, Wang, Wei, Chen, Shujuan, Viale, Andrea, Zheng, Hongwu, Paik, Ji-hye, Lim, Carol, Guimaraes, Alexander R., Martin, Eric S., Chang, Jeffery, Hezel, Aram F., Perry, Samuel R., Hu, Jian, Gan, Boyi, Xiao, Yonghong, Asara, John M., Weissleder, Ralph, Wang, Y. Alan, Chin, Lynda, Cantley, Lewis C., DePinho, Ronald A.

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FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells von Yeo, Hyeonju, Lyssiotis, Costas A, Zhang, Yuqing, Ying, Haoqiang, Asara, John M, Cantley, Lewis C, Paik, Ji-Hye

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Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis von Chen, Ziheng, Ho, I-Lin, Soeung, Melinda, Yen, Er-Yen, Liu, Jintan, Yan, Liang, Rose, Johnathon L., Srinivasan, Sanjana, Jiang, Shan, Edward Chang, Q., Feng, Ningping, Gay, Jason P., Wang, Qi, Wang, Jing, Lorenzi, Philip L., Veillon, Lucas J., Wei, Bo, Weinstein, John N., Deem, Angela K., Gao, Sisi, Genovese, Giannicola, Viale, Andrea, Yao, Wantong, Lyssiotis, Costas A., Marszalek, Joseph R., Draetta, Giulio F., Ying, Haoqiang

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mTOR Drives Its Own Activation via SCF βTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR von Gao, Daming, Inuzuka, Hiroyuki, Tan, Meng-Kwang Marcus, Fukushima, Hidefumi, Locasale, Jason W., Liu, Pengda, Wan, Lixin, Zhai, Bo, Chin, Y. Rebecca, Shaik, Shavali, Lyssiotis, Costas A., Gygi, Steven P., Toker, Alex, Cantley, Lewis C., Asara, John M., Harper, J. Wade, Wei, Wenyi

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Arginase 1 is a key driver of immune suppression in pancreatic cancer von Menjivar, Rosa E, Nwosu, Zeribe C, Du, Wenting, Donahue, Katelyn L, Hong, Hanna S, Espinoza, Carlos, Brown, Kristee, Velez-Delgado, Ashley, Yan, Wei, Lima, Fatima, Bischoff, Allison, Kadiyala, Padma, Salas-Escabillas, Daniel, Crawford, Howard C, Bednar, Filip, Carpenter, Eileen, Zhang, Yaqing, Halbrook, Christopher J, Lyssiotis, Costas A, Pasca di Magliano, Marina

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A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers von Bollong, Michael J., Pietilä, Mika, Pearson, Aaron D., Sarkar, Tapasree Roy, Ahmad, Insha, Soundararajan, Rama, Lyssiotis, Costas A., Mani, Sendurai A., Schultz, Peter G., Lairson, Luke L.

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