Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models von Elbaum, Daniel, Beconi, Maria G, Monteagudo, Edith, Di Marco, Annalise, Quinton, Maria S, Lyons, Kathryn A, Vaino, Andrew, Harper, Steven

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Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker von Abbadie, Catherine, McManus, Owen B, Sun, Shu-Yu, Bugianesi, Randal M, Dai, Ge, Haedo, Rodolfo J, Herrington, James B, Kaczorowski, Gregory J, Smith, McHardy M, Swensen, Andrew M, Warren, Vivien A, Williams, Brande, Arneric, Stephen P, Eduljee, Cyrus, Snutch, Terrance P, Tringham, Elizabeth W, Jochnowitz, Nina, Liang, Annie, Euan MacIntyre, D, McGowan, Erin, Mistry, Shruti, White, Valerie V, Hoyt, Scott B, London, Clare, Lyons, Kathryn A, Bunting, Patricia B, Volksdorf, Sylvia, Duffy, Joseph L

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Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes : Potential importance of selectivity over dipeptidyl peptidases 8 and 9 von LANKAS, George R, LEITING, Barbara, IPPOLITO, Dawn E, KIM, Dooseop, LYONS, Kathryn A, OK, Hyun O, PATEL, Reshma A, PETROV, Aleksandr N, PRYOR, Kelly Ann, XIAOXIA QIAN, REIGLE, Leah, WOODS, Andrea, ROY, Ranabir Sinha, WU, Joseph K, ZALLER, Dennis, XIAOPING ZHANG, LAN ZHU, WEBER, Ann E, THORNBERRY, Nancy A, EIERMANN, George J, BECONI, Maria G, BIFTU, Tesfaye, CHAN, Chi-Chung, EDMONDSON, Scott, FEENEY, William P, HUAIBING HE

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A peripherally acting Na(v)1.7 sodium channel blocker reverses hyperalgesia and allodynia on rat models of inflammatory and neuropathic pain von McGowan, Erin, Hoyt, Scott B, Li, Xiaohua, Lyons, Kathryn A, Abbadie, Catherine

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The Role of Working Memory in Decoding Emotions von Phillips, Louise H, Channon, Shelley, Tunstall, Mary, Hedenstrom, Anna, Lyons, Kathryn

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Structure–activity-relationship of amide and sulfonamide analogs of omarigliptin von Chen, Ping, Feng, Dennis, Qian, Xiaoxia, Apgar, James, Wilkening, Robert, Kuethe, Jeffrey T., Gao, Ying-Duo, Scapin, Giovanna, Cox, Jason, Doss, George, Eiermann, George, He, Huaibing, Li, Xiaohua, Lyons, Kathryn A., Metzger, Joseph, Petrov, Aleksandr, Wu, Joseph K., Xu, Shiyao, Weber, Ann E., Yan, Youwei, Roy, Ranabir Sinha, Biftu, Tesfaye

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The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors von Cox, Jason M., Chu, Hong D., Kuethe, Jeffrey T., Gao, Ying-Duo, Scapin, Giovanna, Eiermann, George, He, Huaibing, Li, Xiaohua, Lyons, Kathryn A., Metzger, Joseph, Petrov, Aleksandr, Wu, Joseph K., Xu, Shiyao, Sinha-Roy, Ranabir, Weber, Ann E., Biftu, Tesfaye

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A Peripherally Acting Nav1.7 Sodium Channel Blocker Reverses Hyperalgesia and Allodynia on Rat Models of Inflammatory and Neuropathic Pain von McGowan, Erin, Hoyt, Scott B., Li, Xiaohua, Lyons, Kathryn A., Abbadie, Catherine

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A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma von Orsatti, Laura, Speziale, Roberto, Orsale, Maria Vittoria, Caretti, Fulvia, Veneziano, Maria, Zini, Matteo, Monteagudo, Edith, Lyons, Kathryn, Beconi, Maria, Chan, Kelvin, Herbst, Todd, Toledo-Sherman, Leticia, Munoz-Sanjuan, Ignacio, Bonelli, Fabio, Dominguez, Celia

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Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors von Edmondson, Scott D., Wei, Lan, Xu, Jinyou, Shang, Jackie, Xu, Shiyao, Pang, Jianmei, Chaudhary, Ashok, Dean, Dennis C., He, Huaibing, Leiting, Barbara, Lyons, Kathryn A., Patel, Reshma A., Patel, Sangita B., Scapin, Giovanna, Wu, Joseph K., Beconi, Maria G., Thornberry, Nancy A., Weber, Ann E.

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Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain von Hoyt, Scott B., London, Clare, Gorin, David, Wyvratt, Matthew J., Fisher, Michael H., Abbadie, Catherine, Felix, John P., Garcia, Maria L., Li, Xiaohua, Lyons, Kathryn A., McGowan, Erin, MacIntyre, D. Euan, Martin, William J., Priest, Birgit T., Ritter, Amy, Smith, McHardy M., Warren, Vivien A., Williams, Brande S., Kaczorowski, Gregory J., Parsons, William H.

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A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain von Hoyt, Scott B., London, Clare, Abbadie, Catherine, Felix, John P., Garcia, Maria L., Jochnowitz, Nina, Karanam, Bindhu V., Li, Xiaohua, Lyons, Kathryn A., McGowan, Erin, Priest, Birgit T., Smith, McHardy M., Warren, Vivien A., Thomas-Fowlkes, Brande S., Kaczorowski, Gregory J., Duffy, Joseph L.

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Pharmacokinetics of memantine in rats and mice von Beconi, Maria G, Howland, David, Park, Larry, Lyons, Kathryn, Giuliano, Joseph, Dominguez, Celia, Munoz-Sanjuan, Ignacio, Pacifici, Robert

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Aminopiperidine Sulfonamide Cav2.2 Channel Inhibitors for the Treatment of Chronic Pain von Shao, Pengcheng P, Ye, Feng, Chakravarty, Prasun K, Varughese, Deepu J, Herrington, James B, Dai, Ge, Bugianesi, Randal M, Haedo, Rodolfo J, Swensen, Andrew M, Warren, Vivien A, Smith, McHardy M, Garcia, Maria L, McManus, Owen B, Lyons, Kathryn A, Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J, Duffy, Joseph L

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Discovery of a novel class of benzazepinone Na(v)1.7 blockers: potential treatments for neuropathic pain von Hoyt, Scott B, London, Clare, Gorin, David, Wyvratt, Matthew J, Fisher, Michael H, Abbadie, Catherine, Felix, John P, Garcia, Maria L, Li, Xiaohua, Lyons, Kathryn A, McGowan, Erin, MacIntyre, D Euan, Martin, William J, Priest, Birgit T, Ritter, Amy, Smith, McHardy M, Warren, Vivien A, Williams, Brande S, Kaczorowski, Gregory J, Parsons, William H

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Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors von Xu, Jinyou, Wei, Lan, Mathvink, Robert, He, Jiafang, Park, You-Jung, He, Huaibing, Leiting, Barbara, Lyons, Kathryn A., Marsilio, Frank, Patel, Reshma A., Wu, Joseph K., Thornberry, Nancy A., Weber, Ann E.

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Synthesis and evaluation of [(1 R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1 R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors von Chen, Ping, Caldwell, Charles G., Ashton, Wallace, Wu, Joseph K., He, Huaibing, Lyons, Kathryn A., Thornberry, Nancy A., Weber, Ann E.

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Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: Close analogs of JANUVIA™ (sitagliptin phosphate) von Kim, Dooseop, Kowalchick, Jennifer E., Edmondson, Scott D., Mastracchio, Anthony, Xu, Jinyou, Eiermann, George J., Leiting, Barbara, Wu, Joseph K., Pryor, KellyAnn D., Patel, Reshma A., He, Huaibing, Lyons, Kathryn A., Thornberry, Nancy A., Weber, Ann E.

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Substituted piperazines as novel dipeptidyl peptidase IV inhibitors von Brockunier, Linda L., He, Jiafang, Colwell, Lawrence F., Habulihaz, Bahanu, He, Huaibing, Leiting, Barbara, Lyons, Kathryn A., Marsilio, Frank, Patel, Reshma A., Teffera, Yohannes, Wu, Joseph K., Thornberry, Nancy A., Weber, Ann E., Parmee, Emma R.

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Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors von Edmondson, Scott D., Mastracchio, Anthony, Cox, Jason M., Eiermann, George J., He, Huaibing, Lyons, Kathryn A., Patel, Reshma A., Patel, Sangita B., Petrov, Aleksandr, Scapin, Giovanna, Wu, Joseph K., Xu, Shiyao, Zhu, Bing, Thornberry, Nancy A., Roy, Ranabir Sinha, Weber, Ann E.

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