P087: Retrospective analysis of comprehensive cancer panel sequencing at Fox Chase Cancer Center to evaluate the QIAGEN Clinical Insight Interpret database von Guo, Tingwei, Baldwin, Don, Tan, Yinfei, Gong, Yulan, Huang, Min, Mackrides, Nicholas, Nejati, Reza, Wang, Yue Lynn, Wasik, Mariusz

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Mechanisms of ibrutinib resistance in chronic lymphocytic leukaemia and non‐Hodgkin lymphoma von Zhang, Shuang Q., Smith, Sonali M., Zhang, Shuang Y., Lynn Wang, Yue

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Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL von Sharma, Shruti, Galanina, Natalie, Guo, Ailin, Lee, Jimmy, Kadri, Sabah, Van Slambrouck, Charles, Long, Bradley, Wang, Weige, Ming, Mei, Furtado, Larissa V, Segal, Jeremy P, Stock, Wendy, Venkataraman, Girish, Tang, Wei-Jen, Lu, Pin, Wang, Yue Lynn

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Dual SYK/JAK Inhibition Overcomes Ibrutinib Resistance in Chronic Lymphocytic Leukemia von Wang, Yue Lynn, Lu, Pin, Coffey, Greg P, Pandey, Anjali, Guo, Ailin

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HSP90 Stabilizes B-Cell Receptor Kinases in a Multi-Client Interactome: PU-H71 Induces CLL Apoptosis in a Cytoprotective Microenvironment von Wang, Yue Lynn, Lu, Pin, Lee, Jimmy, Zhen, Chao Jie, Chiosis, Gabriela, Guo, Ailin

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Abstract PO-019: Ubiquitin E3 ligase OSTM1 regulates the cAMP/PKA/CREB pathway and suppresses B-cell malignancies von Tariq, Muhammad Usama, Shen, Julia, Jung, Jaeyong, Sheshadri, Namratha, Yan, Junrong, Li, Rongrong, Lu, Kevin, Liu, Tong, Li, Hong, Wang, Yue Lynn, Xie, Ping, Zong, Wei-Xing

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An HSP90 Inhibitor, PU-H71, Antagonizes Stroma-Induced Pro-Survival Effects in CLL through Its Inhibition of Multi-Component B-Cell Receptor Signaling Pathway von Guo, Ailin, Lu, Pin, Zhen, Chaojie, Chiosis, Gabriela, Wang, Yue Lynn

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Higher BTK-Dependent Cell Proliferation in Unmutated Chronic Lymphocytic Leukemia Confers Increased Sensitivity to Ibrutinib von Guo, Ailin, Lu, Pin, Galanina, Natalie, Nabhan, Chadi, Smith, Sonali M., Coleman, Morton, Wang, Yue Lynn

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An Accurate and Sensitive RT-qPCR Method That Reliably Detects BCR-ABL1 Beyond MR4.5 von McDonald, Nadia A., Close, Brett E., Lu, Pin, Segal, Jeremy P., Wang, Yue Lynn, Furtado, Larissa V.

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Regulation of self-tolerance by CD80/CD86 interactions von Lu, Pin, Wang, Yue Lynn, Linsley, Peter S

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Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity von Liu, Longqi, Liu, Chuanyu, Quintero, Andrés, Wu, Liang, Yuan, Yue, Wang, Mingyue, Cheng, Mengnan, Leng, Lizhi, Xu, Liqin, Dong, Guoyi, Li, Rui, Liu, Yang, Wei, Xiaoyu, Xu, Jiangshan, Chen, Xiaowei, Lu, Haorong, Chen, Dongsheng, Wang, Quanlei, Zhou, Qing, Lin, Xinxin, Li, Guibo, Liu, Shiping, Wang, Qi, Wang, Hongru, Fink, J. Lynn, Gao, Zhengliang, Liu, Xin, Hou, Yong, Zhu, Shida, Yang, Huanming, Ye, Yunming, Lin, Ge, Chen, Fang, Herrmann, Carl, Eils, Roland, Shang, Zhouchun, Xu, Xun

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Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity von Liu, Xiangdong, Shin, Niu, Koblish, Holly K., Yang, Gengjie, Wang, Qian, Wang, Kathy, Leffet, Lynn, Hansbury, Michael J., Thomas, Beth, Rupar, Mark, Waeltz, Paul, Bowman, Kevin J., Polam, Padmaja, Sparks, Richard B., Yue, Eddy W., Li, Yanlong, Wynn, Richard, Fridman, Jordan S., Burn, Timothy C., Combs, Andrew P., Newton, Robert C., Scherle, Peggy A.

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INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology von Yue, Eddy W, Sparks, Richard, Polam, Padmaja, Modi, Dilip, Douty, Brent, Wayland, Brian, Glass, Brian, Takvorian, Amy, Glenn, Joseph, Zhu, Wenyu, Bower, Michael, Liu, Xiangdong, Leffet, Lynn, Wang, Qian, Bowman, Kevin J, Hansbury, Michael J, Wei, Min, Li, Yanlong, Wynn, Richard, Burn, Timothy C, Koblish, Holly K, Fridman, Jordan S, Emm, Tom, Scherle, Peggy A, Metcalf, Brian, Combs, Andrew P

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Downregulation of PAX6 by shRNA inhibits proliferation and cell cycle progression of human non-small cell lung cancer cell lines von Zhao, Xiaoting, Yue, Wentao, Zhang, Lina, Ma, Li, Jia, Wenyun, Qian, Zhe, Zhang, Chunyan, Wang, Yue

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Elevated plasma D-dimer levels correlate with long term survival of gastric cancer patients von Liu, Long, Zhang, Xi, Yan, Bing, Gu, Qunhao, Zhang, Xiaodong, Jiao, Jianpeng, Sun, Dazhi, Wang, Ning, Yue, Xiaoqiang

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Metagenomic Sequencing Reveals that High-Grain Feeding Alters the Composition and Metabolism of Cecal Microbiota and Induces Cecal Mucosal Injury in Sheep von Xie, Fei, Xu, Lei, Wang, Yue, Mao, Shengyong

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The correlation between the covalent bonds and magnetocaloric properties of the Mn2−xFexPyGe1−yMz compounds von Zhang, H. R., Liu, D. M., Zhang, Z. L., Wang, S. B., Yue, M., Huang, Q. Z., Lynn, J. W.

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Diverse somatic mutation patterns and pathway alterations in human cancers von Kan, Zhengyan, Jaiswal, Bijay S., Stinson, Jeremy, Janakiraman, Vasantharajan, Bhatt, Deepali, Stern, Howard M., Yue, Peng, Haverty, Peter M., Bourgon, Richard, Zheng, Jianbiao, Moorhead, Martin, Chaudhuri, Subhra, Tomsho, Lynn P., Peters, Brock A., Pujara, Kanan, Cordes, Shaun, Davis, David P., Carlton, Victoria E. H., Yuan, Wenlin, Li, Li, Wang, Weiru, Eigenbrot, Charles, Kaminker, Joshua S., Eberhard, David A., Waring, Paul, Schuster, Stephan C., Modrusan, Zora, Zhang, Zemin, Stokoe, David, de Sauvage, Frederic J., Faham, Malek, Seshagiri, Somasekar

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Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignan... von Shin, Niu, Stubbs, Matthew, Koblish, Holly, Yue, Eddy W., Soloviev, Maxim, Douty, Brent, Wang, Kathy He, Wang, Qian, Gao, Mingming, Feldman, Patricia, Yang, Gengjie, Hall, Leslie, Hansbury, Michael, O’Connor, Sybil, Leffet, Lynn, Collins, Robert, Katiyar, Kamna, He, Xin, Waeltz, Paul, Collier, Paul, Lu, Jin, Li, Yun-Long, Li, Yanlong, Liu, Phillip C.C., Burn, Timothy, Covington, Maryanne, Diamond, Sharon, Shuey, Dana, Roberts, Alan, Yeleswaram, Swamy, Hollis, Greg, Metcalf, Brian, Yao, Wenqing, Huber, Reid, Combs, Andrew, Newton, Robert, Scherle, Peggy

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Metagenomic Sequencing Reveals that High-Grain Feeding Alters the Composition and Metabolism of Cecal Microbiota and Induces Cecal Mucosal Injury in Sheep von Xie, Fei, Xu, Lei, Wang, Yue, Mao, Shengyong

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